| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the RMC-6236_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.222698 |
| VIM | vimentin | 0.0994993 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0901628 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0838031 |
| MT2A | metallothionein 2A | 0.0823669 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0716755 |
| ENO1 | enolase 1, (alpha) | 0.0625776 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0622518 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0600507 |
| RPL12 | ribosomal protein L12 | 0.0600258 |
| CD44 | CD44 molecule (Indian blood group) | 0.058252 |
| AHNAK | AHNAK nucleoprotein | 0.0565784 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0535414 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0527649 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0488883 |
| SFTPA2 | surfactant protein A2 | 0.0433856 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0426066 |
| MYOF | myoferlin | 0.042465 |
| RPS8 | ribosomal protein S8 | 0.0410838 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0392509 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0380132 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0376811 |
| SMAD3 | SMAD family member 3 | 0.0367345 |
| B2M | beta-2-microglobulin | 0.0351378 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0350729 |
| TXNIP | thioredoxin interacting protein | 0.0341505 |
| RPS3 | ribosomal protein S3 | 0.0330968 |
| LDHA | lactate dehydrogenase A | 0.0326523 |
| CANX | calnexin | 0.0315101 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.031252 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0309518 |
| DSPP | dentin sialophosphoprotein | 0.0301469 |
| MT1E | metallothionein 1E | 0.0287159 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0281117 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0279533 |
| RACK1 | receptor for activated C kinase 1 | 0.0269314 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0265944 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0255438 |
| RPS27A | ribosomal protein S27a | 0.0253799 |
| PLEC | plectin | 0.0253148 |
| LMNA | lamin A/C | 0.0247984 |
| LOX | lysyl oxidase | 0.0247155 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0242472 |
| TPI1 | triosephosphate isomerase 1 | 0.0239475 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.023614 |
| RPL9 | ribosomal protein L9 | 0.0235648 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0235198 |
| ANXA2 | annexin A2 | 0.0228133 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0227837 |
| RPS2 | ribosomal protein S2 | 0.0223556 |
| DSTN | destrin (actin depolymerizing factor) | 0.0223027 |
| RPL26 | ribosomal protein L26 | 0.0222737 |
| RPS12 | ribosomal protein S12 | 0.0222625 |
| RPS6 | ribosomal protein S6 | 0.0222075 |
| PCBP2 | poly(rC) binding protein 2 | 0.0218552 |
| RPL23 | ribosomal protein L23 | 0.0218233 |
| RPS19 | ribosomal protein S19 | 0.0212129 |
| PCBP3 | poly(rC) binding protein 3 | 0.0211881 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0207691 |
| RPL37A | ribosomal protein L37a | 0.0206458 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0204447 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0202443 |
| RPL7 | ribosomal protein L7 | 0.0201959 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0198042 |
| RPS17 | ribosomal protein S17 | 0.0197082 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0196175 |
| HLA-E | major histocompatibility complex, class I, E | 0.0193007 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0192682 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0192313 |
| RPL35A | ribosomal protein L35a | 0.0191546 |
| CALR | calreticulin | 0.0185305 |
| MLPH | melanophilin | 0.0183799 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0182683 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.018091 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0180065 |
| RPS4X | ribosomal protein S4, X-linked | 0.0178138 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0175605 |
| FAM107B | family with sequence similarity 107, member B | 0.0174404 |
| GOLGB1 | golgin B1 | 0.0173061 |
| RPL11 | ribosomal protein L11 | 0.0166446 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0160246 |
| RPL37 | ribosomal protein L37 | 0.0158312 |
| RPL31 | ribosomal protein L31 | 0.0158226 |
| TMSB4X | thymosin beta 4, X-linked | 0.0157724 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0155147 |
| RPS27 | ribosomal protein S27 | 0.0153154 |
| ATF4 | activating transcription factor 4 | 0.0146923 |
| RPS7 | ribosomal protein S7 | 0.0142506 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0142453 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0142318 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0141619 |
| GPR176 | G protein-coupled receptor 176 | 0.0140902 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0140749 |
| COL1A1 | collagen, type I, alpha 1 | 0.01407 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0140576 |
| RPS14 | ribosomal protein S14 | 0.0140368 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0139637 |
| FTL | ferritin, light polypeptide | 0.0136539 |
| ANGPTL4 | angiopoietin-like 4 | 0.0135686 |
| RPL19 | ribosomal protein L19 | 0.0133838 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.264524 |
| FN1 | fibronectin 1 | -0.256366 |
| CDH13 | cadherin 13 | -0.168088 |
| HMGA2 | high mobility group AT-hook 2 | -0.145733 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.139692 |
| IGF2 | insulin-like growth factor 2 | -0.127523 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.125757 |
| EGR1 | early growth response 1 | -0.115409 |
| COL6A1 | collagen, type VI, alpha 1 | -0.111902 |
| ASPH | aspartate beta-hydroxylase | -0.0893163 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0831344 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0758252 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0681887 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0668756 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0598809 |
| MYO10 | myosin X | -0.0595846 |
| CLMP | CXADR-like membrane protein | -0.0590339 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0586543 |
| RTN4 | reticulon 4 | -0.0579645 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0575548 |
| COL6A2 | collagen, type VI, alpha 2 | -0.05509 |
| GLIS3 | GLIS family zinc finger 3 | -0.0540396 |
| ACTG1 | actin gamma 1 | -0.0539093 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0525058 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0510778 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0504948 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0502244 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0490822 |
| CDCP1 | CUB domain containing protein 1 | -0.0473654 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0470514 |
| TUBB6 | tubulin, beta 6 class V | -0.0470066 |
| VCL | vinculin | -0.0465752 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0463513 |
| PTK2 | protein tyrosine kinase 2 | -0.0452203 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0429674 |
| MCL1 | myeloid cell leukemia 1 | -0.0424423 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0408851 |
| DTNA | dystrobrevin, alpha | -0.0407555 |
| EFNA5 | ephrin-A5 | -0.0401714 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0401226 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0396974 |
| DIAPH2 | diaphanous-related formin 2 | -0.0383561 |
| SETD5 | SET domain containing 5 | -0.0383516 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0383383 |
| SPAG9 | sperm associated antigen 9 | -0.0382649 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0380634 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0376724 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0365232 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0362636 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0360828 |
| HPCAL1 | hippocalcin-like 1 | -0.0358543 |
| NAV1 | neuron navigator 1 | -0.0347914 |
| FMN1 | formin 1 | -0.0341459 |
| FBXO11 | F-box protein 11 | -0.0339001 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0335227 |
| TMSB10 | thymosin beta 10 | -0.0330394 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0330022 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0328573 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0325864 |
| GLG1 | golgi glycoprotein 1 | -0.032232 |
| NUMB | numb homolog (Drosophila) | -0.0317229 |
| GRB10 | growth factor receptor-bound protein 10 | -0.031636 |
| USP3 | ubiquitin specific peptidase 3 | -0.031572 |
| CCND1 | cyclin D1 | -0.031444 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0313621 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.031241 |
| VMP1 | vacuole membrane protein 1 | -0.0311625 |
| ACTN4 | actinin, alpha 4 | -0.0306363 |
| CLIC4 | chloride intracellular channel 4 | -0.0303115 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0301846 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0301292 |
| IER3 | immediate early response 3 | -0.0296119 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0291861 |
| ACTN1 | actinin, alpha 1 | -0.0290047 |
| QKI | QKI, KH domain containing, RNA binding | -0.0289434 |
| NABP1 | nucleic acid binding protein 1 | -0.0287655 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0286626 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0282136 |
| TAOK1 | TAO kinase 1 | -0.0278949 |
| SEC24A | SEC24 family member A | -0.0277459 |
| JMJD1C | jumonji domain containing 1C | -0.0273748 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0273145 |
| WDR45B | WD repeat domain 45B | -0.0272252 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0271134 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0268604 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0268364 |
| PKM | pyruvate kinase, muscle | -0.0268204 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0266511 |
| RLF | rearranged L-myc fusion | -0.0265338 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0265226 |
| USP34 | ubiquitin specific peptidase 34 | -0.0264393 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.026303 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0262174 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0261124 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.025908 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0258647 |
| RAB7A | RAB7A, member RAS oncogene family | -0.025833 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0255424 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.025371 |
| NF1 | neurofibromin 1 | -0.0252323 |
