| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the RMC-6236_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.24698 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.127483 |
| FN1 | fibronectin 1 | 0.117822 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.117654 |
| EXT1 | exostosin glycosyltransferase 1 | 0.105353 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0946992 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0756745 |
| CD44 | CD44 molecule (Indian blood group) | 0.0705414 |
| VIM | vimentin | 0.0649258 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0631402 |
| ENO1 | enolase 1, (alpha) | 0.0577275 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0528176 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0480471 |
| TPM4 | tropomyosin 4 | 0.0467682 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0452079 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0447294 |
| INHBA | inhibin, beta A | 0.044593 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0424388 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0410842 |
| TMSB4X | thymosin beta 4, X-linked | 0.0404255 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.040301 |
| CTSB | cathepsin B | 0.0398267 |
| FBN1 | fibrillin 1 | 0.039424 |
| GOLGB1 | golgin B1 | 0.037536 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0369225 |
| LDHA | lactate dehydrogenase A | 0.0351224 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0345983 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.034598 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0342412 |
| SP100 | SP100 nuclear antigen | 0.0335889 |
| CANX | calnexin | 0.0333833 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0323123 |
| AHNAK | AHNAK nucleoprotein | 0.031735 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0315637 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0305749 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.029721 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0288982 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0283427 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0279945 |
| PLEC | plectin | 0.0278561 |
| VCL | vinculin | 0.0276231 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0274853 |
| CALR | calreticulin | 0.0271695 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0268841 |
| STC1 | stanniocalcin 1 | 0.0264511 |
| B2M | beta-2-microglobulin | 0.0261735 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0261298 |
| HDAC9 | histone deacetylase 9 | 0.0259745 |
| ATXN1 | ataxin 1 | 0.0259084 |
| COL1A1 | collagen, type I, alpha 1 | 0.0255317 |
| RIGI | RNA sensor RIG-I | 0.0254627 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0250194 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0248389 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0246762 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0245544 |
| IL6 | interleukin 6 | 0.0243271 |
| SFTPA2 | surfactant protein A2 | 0.0238694 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0235558 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0232783 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0227957 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0223556 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0222364 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0221859 |
| CALD1 | caldesmon 1 | 0.0220245 |
| COL3A1 | collagen, type III, alpha 1 | 0.0219565 |
| APP | amyloid beta (A4) precursor protein | 0.02193 |
| PLSCR1 | phospholipid scramblase 1 | 0.021789 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0217316 |
| GLIS3 | GLIS family zinc finger 3 | 0.021731 |
| ASPH | aspartate beta-hydroxylase | 0.0215336 |
| NAV1 | neuron navigator 1 | 0.0214191 |
| FAM107B | family with sequence similarity 107, member B | 0.0213151 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.021245 |
| MAP1B | microtubule-associated protein 1B | 0.0209786 |
| MX2 | MX dynamin-like GTPase 2 | 0.0206388 |
| PALLD | palladin, cytoskeletal associated protein | 0.020305 |
| MT2A | metallothionein 2A | 0.02026 |
| KLF6 | Kruppel-like factor 6 | 0.0199569 |
| OSMR | oncostatin M receptor | 0.0198896 |
| ATF4 | activating transcription factor 4 | 0.0197272 |
| CFB | complement factor B | 0.019527 |
| HSPA8 | heat shock 70kDa protein 8 | 0.019101 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0187168 |
| CNTN5 | contactin 5 | 0.0185965 |
| RPS3 | ribosomal protein S3 | 0.0185394 |
| HLA-E | major histocompatibility complex, class I, E | 0.0185353 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.018312 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0182783 |
| RACK1 | receptor for activated C kinase 1 | 0.0182528 |
| RPL26 | ribosomal protein L26 | 0.0181021 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0179595 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0178026 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.017702 |
| HLA-B | major histocompatibility complex, class I, B | 0.0171763 |
| MLF1 | myeloid leukemia factor 1 | 0.0170338 |
| RPS8 | ribosomal protein S8 | 0.0169378 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0165907 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0165719 |
| KIAA1217 | KIAA1217 | 0.0165406 |
| IFI44L | interferon-induced protein 44-like | 0.0163246 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.173632 |
| CADM1 | cell adhesion molecule 1 | -0.0930269 |
| ATP13A3 | ATPase type 13A3 | -0.0755742 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0676026 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0648806 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0641245 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0591486 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0544402 |
| PDE10A | phosphodiesterase 10A | -0.0491841 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0446771 |
| ZNF292 | zinc finger protein 292 | -0.044655 |
| QKI | QKI, KH domain containing, RNA binding | -0.0442324 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0411268 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0410015 |
| USP3 | ubiquitin specific peptidase 3 | -0.0408165 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0383748 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0376179 |
| TRAM1 | translocation associated membrane protein 1 | -0.0329433 |
| SPAG9 | sperm associated antigen 9 | -0.0327722 |
| TFG | TRK-fused gene | -0.0310525 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0294362 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0292537 |
| GOLGA4 | golgin A4 | -0.0288257 |
| SETD5 | SET domain containing 5 | -0.0284669 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0278282 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.02765 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0271395 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0269283 |
| POSTN | periostin, osteoblast specific factor | -0.0266552 |
| RYBP | RING1 and YY1 binding protein | -0.0266068 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0264887 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0263876 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0260824 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0259803 |
| RNF145 | ring finger protein 145 | -0.0250633 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0249409 |
| PDE8A | phosphodiesterase 8A | -0.0243484 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0239597 |
| RTN4 | reticulon 4 | -0.0234778 |
| HMGA1 | high mobility group AT-hook 1 | -0.0234313 |
| RHEB | Ras homolog enriched in brain | -0.0233444 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0231073 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0228767 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0226885 |
| RLF | rearranged L-myc fusion | -0.0226871 |
| COPA | coatomer protein complex, subunit alpha | -0.0224308 |
| HELZ | helicase with zinc finger | -0.0224176 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0218941 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0218692 |
| RBM39 | RNA binding motif protein 39 | -0.0217945 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.02175 |
| CLINT1 | clathrin interactor 1 | -0.0217162 |
| CD109 | CD109 molecule | -0.0216923 |
| COL6A3 | collagen, type VI, alpha 3 | -0.021596 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0214751 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0212782 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.021138 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.021102 |
| PTK2 | protein tyrosine kinase 2 | -0.020758 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0207152 |
| FOXJ3 | forkhead box J3 | -0.0206054 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0205579 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0205368 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0204702 |
| CDH13 | cadherin 13 | -0.0204321 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.0201684 |
| AZIN1 | antizyme inhibitor 1 | -0.0200339 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0200148 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0199771 |
| SEPTIN7 | septin 7 | -0.0197668 |
| LOX | lysyl oxidase | -0.0196666 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0194004 |
| GNAS | GNAS complex locus | -0.0193526 |
| CCNL1 | cyclin L1 | -0.019276 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0192683 |
| SRP54 | signal recognition particle 54kDa | -0.0192481 |
| PFN1 | profilin 1 | -0.0191786 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0191722 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.018789 |
| TMEM165 | transmembrane protein 165 | -0.018676 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0186127 |
| IER3 | immediate early response 3 | -0.0185069 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0182782 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0181188 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0178736 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0178297 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0176815 |
| RYK | receptor-like tyrosine kinase | -0.0176805 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0176627 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0175078 |
| MATR3 | matrin 3 | -0.0174785 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0174643 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0174512 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0173701 |
| RASA2 | RAS p21 protein activator 2 | -0.0167979 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0165877 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0164442 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | -0.0164406 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0163371 |
| SQLE | squalene epoxidase | -0.0163342 |
