| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the RMC-6236_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.187934 |
| LMO7 | LIM domain 7 | 0.152834 |
| EXT1 | exostosin glycosyltransferase 1 | 0.143193 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0874974 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0800982 |
| SMAD3 | SMAD family member 3 | 0.0741983 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0694985 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0667263 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0623748 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0601326 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0596957 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0577568 |
| TJP1 | tight junction protein 1 | 0.0571639 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0562103 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0542166 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0532232 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0502161 |
| NTN4 | netrin 4 | 0.0501138 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.05009 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.04874 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0483225 |
| TLE4 | transducin-like enhancer of split 4 | 0.0454175 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0451965 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0449358 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0433766 |
| EXPH5 | exophilin 5 | 0.0429256 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.042483 |
| DPP4 | dipeptidyl-peptidase 4 | 0.0418839 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | 0.0409169 |
| ATXN1 | ataxin 1 | 0.0393973 |
| AREG | amphiregulin | 0.038116 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0370694 |
| VCL | vinculin | 0.0368544 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0365713 |
| AXIN2 | axin 2 | 0.0363202 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0361342 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0356336 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0353029 |
| B2M | beta-2-microglobulin | 0.0352855 |
| RPS12 | ribosomal protein S12 | 0.0352074 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0349103 |
| RPS3 | ribosomal protein S3 | 0.0348544 |
| PLK2 | polo-like kinase 2 | 0.0346809 |
| DUSP16 | dual specificity phosphatase 16 | 0.0340957 |
| MYOF | myoferlin | 0.0339162 |
| KLF6 | Kruppel-like factor 6 | 0.0337241 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0334688 |
| PGCKA1 | PDCD10 and GCKIII kinases associated 1 | 0.0327264 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0305725 |
| CCNYL1 | cyclin Y-like 1 | 0.0302828 |
| TMC5 | transmembrane channel-like 5 | 0.0301421 |
| SIK3 | SIK family kinase 3 | 0.0297466 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0295891 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0294301 |
| FAT1 | FAT atypical cadherin 1 | 0.0293157 |
| MYO5B | myosin VB | 0.0288592 |
| RND3 | Rho family GTPase 3 | 0.0281717 |
| NEBL | nebulette | 0.0274481 |
| RPS2 | ribosomal protein S2 | 0.0272485 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0269346 |
| SHROOM3 | shroom family member 3 | 0.0267884 |
| GLCCI1 | glucocorticoid induced 1 | 0.0267434 |
| PDZD8 | PDZ domain containing 8 | 0.0265198 |
| INTS6 | integrator complex subunit 6 | 0.026459 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.0264355 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0264057 |
| FHL2 | four and a half LIM domains 2 | 0.0256334 |
| RPS8 | ribosomal protein S8 | 0.0253792 |
| EREG | epiregulin | 0.0253747 |
| ETV6 | ets variant 6 | 0.0252715 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0251952 |
| MYZAP | myocardial zonula adherens protein | 0.0251848 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0245135 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0244887 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0243501 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0243256 |
| LCN2 | lipocalin 2 | 0.0242997 |
| DST | dystonin | 0.0240524 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0239376 |
| RPS17 | ribosomal protein S17 | 0.0235108 |
| PRR5L | proline rich 5 like | 0.0231039 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0229131 |
| FAM107B | family with sequence similarity 107, member B | 0.0227716 |
| PCBP2 | poly(rC) binding protein 2 | 0.0218782 |
| SGMS2 | sphingomyelin synthase 2 | 0.0215233 |
| RPL23 | ribosomal protein L23 | 0.0214517 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0211811 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.021068 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0208372 |
| ATF3 | activating transcription factor 3 | 0.0203711 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0199419 |
| RASEF | RAS and EF-hand domain containing | 0.0196285 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0187283 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.018707 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0186987 |
| RPL3 | ribosomal protein L3 | 0.0183471 |
| RACK1 | receptor for activated C kinase 1 | 0.0182832 |
| MYADM | myeloid-associated differentiation marker | 0.0180012 |
| WWOX | WW domain containing oxidoreductase | 0.0177022 |
| RPL9 | ribosomal protein L9 | 0.0176543 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ANXA2 | annexin A2 | -0.114837 |
| NDRG1 | N-myc downstream regulated 1 | -0.111851 |
| ACTN4 | actinin, alpha 4 | -0.107385 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.103052 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0973896 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0963812 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0908497 |
| SLC45A4 | solute carrier family 45, member 4 | -0.0902759 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.08818 |
| WASF2 | WAS protein family, member 2 | -0.0843682 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0812687 |
| LYZ | lysozyme | -0.0774451 |
| PTMA | prothymosin, alpha | -0.0766766 |
| PTK2 | protein tyrosine kinase 2 | -0.074354 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0740879 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0721016 |
| NF1 | neurofibromin 1 | -0.0706394 |
| TXNRD1 | thioredoxin reductase 1 | -0.0680599 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0679678 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0630144 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0629573 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.058989 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0579398 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0569239 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0568419 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0561226 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0552106 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0516415 |
| NIBAN2 | niban apoptosis regulator 2 | -0.0514779 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0514168 |
| STK24 | serine/threonine kinase 24 | -0.0511582 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0509551 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0509379 |
| S100A6 | S100 calcium binding protein A6 | -0.050011 |
| KRT8 | keratin 8, type II | -0.0499253 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0498909 |
| DIAPH2 | diaphanous-related formin 2 | -0.0496196 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0491128 |
| ITGA6 | integrin, alpha 6 | -0.047726 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0476978 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0476047 |
| LDHA | lactate dehydrogenase A | -0.0470245 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0464946 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0457306 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.045493 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0453586 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0450744 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0448695 |
| TMSB10 | thymosin beta 10 | -0.0447834 |
| LAMA4 | laminin, alpha 4 | -0.0446148 |
| DGKH | diacylglycerol kinase, eta | -0.0445032 |
| EZR | ezrin | -0.0442626 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0439366 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0435626 |
| EGR1 | early growth response 1 | -0.043107 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0428136 |
| SQSTM1 | sequestosome 1 | -0.0425698 |
| RTN4 | reticulon 4 | -0.0425055 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0416149 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0409793 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0409193 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0408678 |
| AGR2 | anterior gradient 2 | -0.0398987 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0396155 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0394013 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0393499 |
| THOC2 | THO complex 2 | -0.0393411 |
| HDLBP | high density lipoprotein binding protein | -0.0389621 |
| COG5 | component of oligomeric golgi complex 5 | -0.0380497 |
| SDC4 | syndecan 4 | -0.0380324 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0377072 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0371981 |
| SBF2 | SET binding factor 2 | -0.0367012 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.036663 |
| USP34 | ubiquitin specific peptidase 34 | -0.0366449 |
| ZNF292 | zinc finger protein 292 | -0.036493 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0363738 |
| KLF10 | Kruppel-like factor 10 | -0.036352 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.036085 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.035808 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0355917 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.035505 |
| PGK1 | phosphoglycerate kinase 1 | -0.0351645 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0348329 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | -0.0338964 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0337115 |
| CLTC | clathrin, heavy chain (Hc) | -0.0335595 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0332427 |
| RBM39 | RNA binding motif protein 39 | -0.0329968 |
| WWC1 | WW and C2 domain containing 1 | -0.0327925 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0323383 |
| ACTG1 | actin gamma 1 | -0.0322947 |
| BBX | bobby sox homolog (Drosophila) | -0.0318919 |
| AHNAK | AHNAK nucleoprotein | -0.0317982 |
| RRBP1 | ribosome binding protein 1 | -0.0316233 |
| JUP | junction plakoglobin | -0.0315324 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0314199 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0311849 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0310651 |
| DNM2 | dynamin 2 | -0.0310003 |
