| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the RMC-6236_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.314579 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.1518 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.125212 |
| DSPP | dentin sialophosphoprotein | 0.0949654 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.08679 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0671867 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0651821 |
| CTSB | cathepsin B | 0.0571758 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.056267 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.054306 |
| CFB | complement factor B | 0.0529196 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0516142 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0461516 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0455925 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0455151 |
| FOXP1 | forkhead box P1 | 0.0408396 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0405231 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0391299 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0385817 |
| RPL37A | ribosomal protein L37a | 0.0377024 |
| FAM107B | family with sequence similarity 107, member B | 0.0368157 |
| RPS12 | ribosomal protein S12 | 0.0367037 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0365121 |
| SVIL | supervillin | 0.0360616 |
| TCIM | transcriptional and immune response regulator | 0.0358659 |
| PLIN2 | perilipin 2 | 0.0354052 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.034966 |
| DSTN | destrin (actin depolymerizing factor) | 0.0344285 |
| CP | ceruloplasmin (ferroxidase) | 0.0340701 |
| RACK1 | receptor for activated C kinase 1 | 0.0322959 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.030915 |
| AHR | aryl hydrocarbon receptor | 0.0307894 |
| SIK3 | SIK family kinase 3 | 0.030502 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0300164 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0297459 |
| LCN2 | lipocalin 2 | 0.0296651 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0291163 |
| CANX | calnexin | 0.028919 |
| ATF4 | activating transcription factor 4 | 0.0284627 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0277285 |
| TNS1 | tensin 1 | 0.0273925 |
| RPS3 | ribosomal protein S3 | 0.0270958 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0263846 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.025942 |
| RPS7 | ribosomal protein S7 | 0.0254449 |
| RPL26 | ribosomal protein L26 | 0.0252684 |
| ORM1 | orosomucoid 1 | 0.0244453 |
| TF | transferrin | 0.0241438 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0241429 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0236609 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0229989 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0228187 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0228147 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0227331 |
| ATF3 | activating transcription factor 3 | 0.0226851 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0222139 |
| SIK2 | salt-inducible kinase 2 | 0.0219718 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0219027 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0218645 |
| RPS17 | ribosomal protein S17 | 0.021556 |
| RSU1 | Ras suppressor protein 1 | 0.0208816 |
| DTNA | dystrobrevin, alpha | 0.0202181 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.0201519 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0200746 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0199452 |
| EFNA1 | ephrin-A1 | 0.0198998 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0194892 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0189864 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | 0.0187931 |
| CRY1 | cryptochrome circadian clock 1 | 0.0187595 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.0186762 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0185757 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0179269 |
| SFTPA2 | surfactant protein A2 | 0.0178602 |
| B2M | beta-2-microglobulin | 0.0177385 |
| RPL9 | ribosomal protein L9 | 0.0176178 |
| KYNU | kynureninase | 0.0176021 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0174518 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0171877 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0171125 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0170754 |
| RPL31 | ribosomal protein L31 | 0.0167793 |
| MYO1E | myosin IE | 0.0166288 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0165484 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0164822 |
| SON | SON DNA binding protein | 0.0164811 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0164251 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 0.0160562 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0159753 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0156612 |
| JAK1 | Janus kinase 1 | 0.0156268 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0156038 |
| KIF21A | kinesin family member 21A | 0.015519 |
| STC2 | stanniocalcin 2 | 0.0154955 |
| PHF10 | PHD finger protein 10 | 0.0154538 |
| RPL5 | ribosomal protein L5 | 0.0151658 |
| CPE | carboxypeptidase E | 0.015076 |
| BRD2 | bromodomain containing 2 | 0.0149463 |
| PDLIM3 | PDZ and LIM domain 3 | 0.0148245 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0148218 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.28448 |
| FN1 | fibronectin 1 | -0.168648 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.16593 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.160591 |
| APOA2 | apolipoprotein A-II | -0.124051 |
| FNDC3B | fibronectin type III domain containing 3B | -0.121061 |
| SLC38A2 | solute carrier family 38, member 2 | -0.118667 |
| MT2A | metallothionein 2A | -0.105637 |
| EHBP1 | EH domain binding protein 1 | -0.0989631 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0857547 |
| APOB | apolipoprotein B | -0.0811942 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.080783 |
| TMEM123 | transmembrane protein 123 | -0.0762794 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0754496 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0720578 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0713113 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0680996 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.065404 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0589194 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0569119 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0563851 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0534344 |
| NPAS2 | neuronal PAS domain protein 2 | -0.052977 |
| TRIM26 | tripartite motif containing 26 | -0.0482575 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0476564 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0474094 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0472168 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0463337 |
| LYZ | lysozyme | -0.0441587 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0439674 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0438884 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0427141 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0423458 |
| EGR1 | early growth response 1 | -0.0420329 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0419361 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0410591 |
| FRMD5 | FERM domain containing 5 | -0.0408385 |
| HMGA1 | high mobility group AT-hook 1 | -0.0397627 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0390599 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0389886 |
| DST | dystonin | -0.0386011 |
| A2M | alpha-2-macroglobulin | -0.0385841 |
| RBM39 | RNA binding motif protein 39 | -0.0381192 |
| GPC6 | glypican 6 | -0.0375144 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0374433 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0368566 |
| SDC4 | syndecan 4 | -0.0366865 |
| VMP1 | vacuole membrane protein 1 | -0.036492 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0362822 |
| MALT1 | MALT1 paracaspase | -0.035189 |
| GNAS | GNAS complex locus | -0.0348839 |
| LOC112694756 | uncharaterized LOC112694756 | -0.034483 |
| GPC3 | glypican 3 | -0.0341682 |
| PKM | pyruvate kinase, muscle | -0.0341501 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0340159 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0337666 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0337564 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0330071 |
| ASPH | aspartate beta-hydroxylase | -0.0327755 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0326472 |
| FMNL2 | formin-like 2 | -0.0323083 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0319141 |
| TPM4 | tropomyosin 4 | -0.0318716 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0315123 |
| GLG1 | golgi glycoprotein 1 | -0.0308848 |
| DENND4A | DENN/MADD domain containing 4A | -0.0306575 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0305846 |
| KIF1B | kinesin family member 1B | -0.0304817 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0304265 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.0303955 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0302714 |
| RTN4 | reticulon 4 | -0.0299915 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0299829 |
| JMJD1C | jumonji domain containing 1C | -0.0296416 |
| ATP10A | ATPase, class V, type 10A | -0.0294471 |
| FBXO11 | F-box protein 11 | -0.0294006 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0293959 |
| WDR45B | WD repeat domain 45B | -0.0293652 |
| FTL | ferritin, light polypeptide | -0.0288224 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0287739 |
| NFIA | nuclear factor I/A | -0.0287034 |
| MSI2 | musashi RNA-binding protein 2 | -0.0285999 |
| PTK2 | protein tyrosine kinase 2 | -0.0285792 |
| PEG10 | paternally expressed 10 | -0.0285557 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0283283 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.028231 |
| OSMR | oncostatin M receptor | -0.0281572 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0275626 |
| SBF2 | SET binding factor 2 | -0.0275179 |
| IER3 | immediate early response 3 | -0.0272769 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0268459 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0267341 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0265553 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0261943 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.025685 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0255753 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.025492 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0253722 |
| ANGPTL8 | angiopoietin like 8 | -0.0253358 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0251876 |
