| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the RMC-6236_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.171507 |
| CLU | clusterin | 0.131597 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0888402 |
| B2M | beta-2-microglobulin | 0.0871234 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0763266 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0743157 |
| MT2A | metallothionein 2A | 0.074031 |
| MYOF | myoferlin | 0.072773 |
| TMSB4X | thymosin beta 4, X-linked | 0.0661834 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.063428 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0572051 |
| IFI44L | interferon-induced protein 44-like | 0.0571156 |
| ENO1 | enolase 1, (alpha) | 0.0562251 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0514323 |
| HLA-E | major histocompatibility complex, class I, E | 0.0508903 |
| KRT17 | keratin 17, type I | 0.0493486 |
| RPS8 | ribosomal protein S8 | 0.0479236 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0472033 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0471368 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0461687 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.045174 |
| LMO7 | LIM domain 7 | 0.042019 |
| MEF2A | myocyte enhancer factor 2A | 0.0419768 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0418606 |
| RPS3 | ribosomal protein S3 | 0.0414068 |
| SQSTM1 | sequestosome 1 | 0.0409601 |
| TXNIP | thioredoxin interacting protein | 0.0409329 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0390889 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0381415 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0380998 |
| AHNAK | AHNAK nucleoprotein | 0.0380865 |
| RPS12 | ribosomal protein S12 | 0.0377155 |
| RPL37 | ribosomal protein L37 | 0.0365551 |
| MX1 | MX dynamin-like GTPase 1 | 0.0361651 |
| RPS6 | ribosomal protein S6 | 0.0345742 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0344435 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0340222 |
| ANXA1 | annexin A1 | 0.0336299 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0335972 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.032799 |
| DSTN | destrin (actin depolymerizing factor) | 0.0326417 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0321205 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0317937 |
| RACK1 | receptor for activated C kinase 1 | 0.0317375 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0315588 |
| IFI44 | interferon-induced protein 44 | 0.0315367 |
| SP100 | SP100 nuclear antigen | 0.0309126 |
| HLA-B | major histocompatibility complex, class I, B | 0.0305178 |
| LDHA | lactate dehydrogenase A | 0.0304892 |
| ARRDC3 | arrestin domain containing 3 | 0.0288059 |
| MT1E | metallothionein 1E | 0.0282545 |
| RPL12 | ribosomal protein L12 | 0.0279024 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.02785 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0278445 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0275867 |
| RPS2 | ribosomal protein S2 | 0.0272105 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0272091 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0271055 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0268202 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0267904 |
| ADAR | adenosine deaminase, RNA-specific | 0.0265344 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0265044 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0263916 |
| RPL11 | ribosomal protein L11 | 0.0261275 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0258546 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0257276 |
| RPL37A | ribosomal protein L37a | 0.0250539 |
| RPS4X | ribosomal protein S4, X-linked | 0.0248667 |
| GBP4 | guanylate binding protein 4 | 0.024763 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0240522 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0240418 |
| ATF4 | activating transcription factor 4 | 0.0233114 |
| SET | SET nuclear proto-oncogene | 0.0232993 |
| RPL26 | ribosomal protein L26 | 0.0231324 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0231188 |
| RAI14 | retinoic acid induced 14 | 0.0230864 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.0230338 |
| RPS19 | ribosomal protein S19 | 0.0229549 |
| MXRA5 | matrix-remodelling associated 5 | 0.0224696 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0223821 |
| RPLP0 | ribosomal protein, large, P0 | 0.0221527 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0221102 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0219672 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0216557 |
| CLDN1 | claudin 1 | 0.0215673 |
| PCDH1 | protocadherin 1 | 0.021359 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0211722 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0210169 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0208102 |
| SLK | STE20-like kinase | 0.0206037 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | 0.0205862 |
| TGM2 | transglutaminase 2 | 0.0205709 |
| KCTD12 | potassium channel tetramerization domain containing 12 | 0.0204122 |
| RPL5 | ribosomal protein L5 | 0.0196941 |
| SFTPA2 | surfactant protein A2 | 0.0195837 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0194627 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0194622 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0192781 |
| APOL1 | apolipoprotein L, 1 | 0.0192094 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.019136 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FLNB | filamin B, beta | -0.257411 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.24658 |
| FOXO1 | forkhead box O1 | -0.0988475 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0895668 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0820844 |
| BCL2L1 | BCL2-like 1 | -0.0791468 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0740432 |
| ITGA6 | integrin, alpha 6 | -0.0732003 |
| VCL | vinculin | -0.0682817 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0672195 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0664882 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0647469 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0646999 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.056821 |
| EGR1 | early growth response 1 | -0.056556 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.056553 |
| EMP1 | epithelial membrane protein 1 | -0.0565291 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0551649 |
| NDRG1 | N-myc downstream regulated 1 | -0.0539616 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.0535781 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0529008 |
| RASAL2 | RAS protein activator like 2 | -0.0502305 |
| HM13 | histocompatibility (minor) 13 | -0.0501173 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0471681 |
| RCOR1 | REST corepressor 1 | -0.0458677 |
| CAPRIN2 | caprin family member 2 | -0.0453289 |
| FN1 | fibronectin 1 | -0.0446018 |
| LAMA5 | laminin, alpha 5 | -0.0421021 |
| COPA | coatomer protein complex, subunit alpha | -0.0420716 |
| PALLD | palladin, cytoskeletal associated protein | -0.0419015 |
| CALU | calumenin | -0.0413354 |
| NEK7 | NIMA-related kinase 7 | -0.0406581 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.039695 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0391646 |
| DUSP6 | dual specificity phosphatase 6 | -0.0386158 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.038358 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0381128 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0377479 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0375678 |
| MCL1 | myeloid cell leukemia 1 | -0.0374564 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0367572 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0365696 |
| RBM39 | RNA binding motif protein 39 | -0.0363962 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0361623 |
| MYO10 | myosin X | -0.0361209 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0356735 |
| SULF1 | sulfatase 1 | -0.0355351 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0352808 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0351962 |
| SMYD3 | SET and MYND domain containing 3 | -0.0351408 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0344642 |
| LUZP1 | leucine zipper protein 1 | -0.0338533 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0335931 |
| MSN | moesin | -0.0335749 |
| ASPH | aspartate beta-hydroxylase | -0.0334997 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -0.0334679 |
| ACTN1 | actinin, alpha 1 | -0.0326104 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0325904 |
| WASF2 | WAS protein family, member 2 | -0.0322093 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0317644 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0317595 |
| FOSL1 | FOS-like antigen 1 | -0.0315439 |
| OSMR | oncostatin M receptor | -0.031535 |
| IGF2 | insulin-like growth factor 2 | -0.0314405 |
| LDLR | low density lipoprotein receptor | -0.031393 |
| SETX | senataxin | -0.0310836 |
| PODXL | podocalyxin-like | -0.0310616 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0309714 |
| POTEF | POTE ankyrin domain family, member F | -0.0305213 |
| CDK6 | cyclin-dependent kinase 6 | -0.0304097 |
| GLG1 | golgi glycoprotein 1 | -0.0292183 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.02916 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0289833 |
| C4BPB | complement component 4 binding protein, beta | -0.0289408 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0288862 |
| CMIP | c-Maf inducing protein | -0.0283779 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0280414 |
| SLC45A4 | solute carrier family 45, member 4 | -0.027933 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.027807 |
| CD44 | CD44 molecule (Indian blood group) | -0.0276442 |
| RAB10 | RAB10, member RAS oncogene family | -0.0276084 |
| TMSB10 | thymosin beta 10 | -0.0275704 |
| RTN4 | reticulon 4 | -0.0275268 |
| ACTN4 | actinin, alpha 4 | -0.0272305 |
| FOXP1 | forkhead box P1 | -0.0270495 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0270165 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.026972 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0268757 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0264307 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0261841 |
| INTS6 | integrator complex subunit 6 | -0.0261832 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0261277 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.02595 |
| NLRP1 | NLR family, pyrin domain containing 1 | -0.0259298 |
| STC1 | stanniocalcin 1 | -0.025922 |
| GRK5 | G protein-coupled receptor kinase 5 | -0.0257935 |
| PLS3 | plastin 3 | -0.0257122 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0256775 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0256656 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0255542 |
