RMC-6236_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description RMC-6236 perturbation in J82 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the RMC-6236_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.385516
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.15731
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0825058
MYH9 myosin, heavy chain 9, non-muscle 0.0736829
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0699493
SLC12A8 solute carrier family 12, member 8 0.0625086
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0490315
B2M beta-2-microglobulin 0.0456012
SET SET nuclear proto-oncogene 0.0426577
TXNRD1 thioredoxin reductase 1 0.0415211
DIO2 deiodinase, iodothyronine, type II 0.0393456
MBNL2 muscleblind-like splicing regulator 2 0.0391496
LDHA lactate dehydrogenase A 0.0384942
EEF2 eukaryotic translation elongation factor 2 0.0384783
MAP1B microtubule-associated protein 1B 0.037122
PCBP2 poly(rC) binding protein 2 0.0370516
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0367371
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0358778
ENO1 enolase 1, (alpha) 0.0355949
PLIN2 perilipin 2 0.033691
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0332773
FLNA filamin A, alpha 0.0324152
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0322623
KTN1 kinectin 1 (kinesin receptor) 0.0322013
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0309708
SRRM2 serine/arginine repetitive matrix 2 0.0307924
EZR ezrin 0.0303363
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0298231
LIMA1 LIM domain and actin binding 1 0.0289327
CENPF centromere protein F, 350/400kDa 0.0284001
TPM3 tropomyosin 3 0.0281224
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0268585
ANXA1 annexin A1 0.0260168
SFTPA2 surfactant protein A2 0.0252917
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0243984
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0243296
KRT7 keratin 7, type II 0.0242601
YBX1 Y box binding protein 1 0.0238025
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0230093
LOC102724023 ES1 protein homolog, mitochondrial 0.0228564
GOLGB1 golgin B1 0.0226709
MKI67 marker of proliferation Ki-67 0.022361
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0217155
SQSTM1 sequestosome 1 0.0212448
FAM107B family with sequence similarity 107, member B 0.0204018
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0203878
OPTN optineurin 0.0202742
TLN1 talin 1 0.0199508
L1CAM L1 cell adhesion molecule 0.0199194
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0198764
IFI44L interferon-induced protein 44-like 0.0198299
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0195141
POTEF POTE ankyrin domain family, member F 0.0192145
CALD1 caldesmon 1 0.0190347
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0190289
SAMD9 sterile alpha motif domain containing 9 0.0189201
PLSCR1 phospholipid scramblase 1 0.0187659
DST dystonin 0.0181999
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0181461
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0181263
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0177314
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0176947
RNF213 ring finger protein 213 0.0175481
NFE2L1 nuclear factor, erythroid 2-like 1 0.0174976
SMC1A structural maintenance of chromosomes 1A 0.017336
RPS2 ribosomal protein S2 0.0173322
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0172741
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0171473
HEG1 heart development protein with EGF-like domains 1 0.0168907
RHOA ras homolog family member A 0.0167571
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0166402
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0166331
RND3 Rho family GTPase 3 0.0159481
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0158719
MSN moesin 0.0158147
MX1 MX dynamin-like GTPase 1 0.015732
TLE4 transducin-like enhancer of split 4 0.0156902
TPI1 triosephosphate isomerase 1 0.0156809
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0155937
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0155235
ARRDC3 arrestin domain containing 3 0.0154222
CANX calnexin 0.0153488
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0152547
KRT18 keratin 18, type I 0.0149034
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0148446
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0148315
GPR176 G protein-coupled receptor 176 0.0146395
TGFB2 transforming growth factor, beta 2 0.014541
FILIP1L filamin A interacting protein 1-like 0.0142849
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0142021
USP9X ubiquitin specific peptidase 9, X-linked 0.0141883
ENAH enabled homolog (Drosophila) 0.0141579
C6ORF62 chromosome 6 open reading frame 62 0.0141511
PLK2 polo-like kinase 2 0.014073
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0139187
MYADM myeloid-associated differentiation marker 0.013844
RIOK3 RIO kinase 3 0.0137994
EIF5 eukaryotic translation initiation factor 5 0.0137819
ZNF841 zinc finger protein 841 0.013772
FBXO32 F-box protein 32 0.0136877

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.242668
NALF1 NALCN channel auxiliary factor 1 -0.242438
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.15664
HLA-B major histocompatibility complex, class I, B -0.148803
ABI3BP ABI family, member 3 (NESH) binding protein -0.132564
PHACTR1 phosphatase and actin regulator 1 -0.124678
EXT1 exostosin glycosyltransferase 1 -0.0908679
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0844267
DLG1 discs, large homolog 1 (Drosophila) -0.0573754
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0542704
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0540453
MT2A metallothionein 2A -0.0538325
ATP13A3 ATPase type 13A3 -0.0517043
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0496902
GLIS3 GLIS family zinc finger 3 -0.0485803
MT1X metallothionein 1X -0.0478602
CD44 CD44 molecule (Indian blood group) -0.0447267
ASPH aspartate beta-hydroxylase -0.0429036
IGFBP3 insulin-like growth factor binding protein 3 -0.0425489
DTNA dystrobrevin, alpha -0.0424579
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0415704
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0412157
UGCG UDP-glucose ceramide glucosyltransferase -0.0406909
DEK DEK proto-oncogene -0.0405788
PLCB4 phospholipase C, beta 4 -0.0397222
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0391079
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.038066
RAI14 retinoic acid induced 14 -0.0379388
F3 coagulation factor III (thromboplastin, tissue factor) -0.0364685
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0352585
NAMPT nicotinamide phosphoribosyltransferase -0.0352285
TPT1 tumor protein, translationally-controlled 1 -0.0348789
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0341809
TRIO trio Rho guanine nucleotide exchange factor -0.0340426
ZNF804A zinc finger protein 804A -0.0332559
GNAS GNAS complex locus -0.0329544
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0326359
PODXL podocalyxin-like -0.0323362
STAU1 staufen double-stranded RNA binding protein 1 -0.0323338
NDRG1 N-myc downstream regulated 1 -0.0320724
FNDC3B fibronectin type III domain containing 3B -0.0318456
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0313685
HLA-A major histocompatibility complex, class I, A -0.0313652
CCBE1 collagen and calcium binding EGF domains 1 -0.0312618
TMSB10 thymosin beta 10 -0.0303007
SAMD12 sterile alpha motif domain containing 12 -0.029687
KPNB1 karyopherin (importin) beta 1 -0.0285188
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0281334
MARCHF6 membrane associated ring-CH-type finger 6 -0.0280956
WNT5B wingless-type MMTV integration site family, member 5B -0.0280946
PTK2 protein tyrosine kinase 2 -0.0277504
FTL ferritin, light polypeptide -0.027521
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0273991
CCND1 cyclin D1 -0.0271557
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0270938
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0269765
CTSD cathepsin D -0.0267135
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0264927
RALY RALY heterogeneous nuclear ribonucleoprotein -0.026449
MMP12 matrix metallopeptidase 12 -0.0259812
OSMR oncostatin M receptor -0.025877
SMYD3 SET and MYND domain containing 3 -0.0258158
ANKRD10 ankyrin repeat domain 10 -0.024989
RAP1B RAP1B, member of RAS oncogene family -0.0243076
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0242716
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0239893
MAML2 mastermind-like 2 (Drosophila) -0.0233282
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0232044
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.022829
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0227341
CAST calpastatin -0.0226786
PRELID2 PRELI domain containing 2 -0.0222602
RBM39 RNA binding motif protein 39 -0.0221625
LOC112694756 uncharaterized LOC112694756 -0.0220219
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0220001
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0218251
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0218174
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0217804
NSD2 nuclear receptor binding SET domain protein 2 -0.021693
TMEM41B transmembrane protein 41B -0.0216484
FAF1 Fas (TNFRSF6) associated factor 1 -0.0214594
RAB7A RAB7A, member RAS oncogene family -0.021358
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0213394
RTN4 reticulon 4 -0.0211437
SBF2 SET binding factor 2 -0.0210912
CDK17 cyclin-dependent kinase 17 -0.0210544
ZFAND3 zinc finger, AN1-type domain 3 -0.0209296
ARF4 ADP-ribosylation factor 4 -0.0209216
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0208358
HLA-C major histocompatibility complex, class I, C -0.0208141
NF1 neurofibromin 1 -0.0205149
TUBB tubulin, beta class I -0.0204322
DPYD dihydropyrimidine dehydrogenase -0.0203894
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0203768
PTPRM protein tyrosine phosphatase, receptor type, M -0.0203234
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0202126
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0199868
RPL27A ribosomal protein L27a -0.0199398
THSD4 thrombospondin, type I, domain containing 4 -0.0197402
IARS1 isoleucyl-tRNA synthetase 1 -0.0194841