RMC-6236_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description RMC-6236 perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the RMC-6236_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.144481
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.111751
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0781091
LMO7 LIM domain 7 0.072979
LOC102724023 ES1 protein homolog, mitochondrial 0.0671672
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0473834
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0452657
FAT1 FAT atypical cadherin 1 0.0434173
KLF5 Kruppel-like factor 5 (intestinal) 0.0402083
HSPA8 heat shock 70kDa protein 8 0.0355175
MYO1E myosin IE 0.0248537
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0246709
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0239405
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0233647
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.021402
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0203152
AFF1 AF4/FMR2 family, member 1 0.0202351
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0199768
LGALS3 lectin, galactoside-binding, soluble, 3 0.0193595
UNC13B unc-13 homolog B (C. elegans) 0.0185113
PELI1 pellino E3 ubiquitin protein ligase 1 0.0183697
EGFR epidermal growth factor receptor 0.0183131
PTPRK protein tyrosine phosphatase, receptor type, K 0.0182255
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.017523
SIM2 single-minded family bHLH transcription factor 2 0.0173553
MARCHF3 membrane associated ring-CH-type finger 3 0.01601
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0156284
TGFBR3 transforming growth factor, beta receptor III 0.0153793
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0152567
MUC13 mucin 13, cell surface associated 0.0152145
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.014942
ZFP36L2 ZFP36 ring finger protein-like 2 0.0148599
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0148242
DSPP dentin sialophosphoprotein 0.0144568
SMAD2 SMAD family member 2 0.0139888
SOX9 SRY (sex determining region Y)-box 9 0.0134322
EPHB2 EPH receptor B2 0.0133463
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0132417
TMC5 transmembrane channel-like 5 0.0129443
RPS2 ribosomal protein S2 0.0129267
SAMD5 sterile alpha motif domain containing 5 0.01283
HDAC2 histone deacetylase 2 0.0126374
NEBL nebulette 0.0125968
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0123395
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.0122496
PDE4D phosphodiesterase 4D, cAMP-specific 0.0118403
SOX4 SRY (sex determining region Y)-box 4 0.011668
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0116549
AXIN2 axin 2 0.0114988
STC2 stanniocalcin 2 0.011478
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0114463
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0113119
EEF2 eukaryotic translation elongation factor 2 0.0112752
PDE10A phosphodiesterase 10A 0.0112227
RPS7 ribosomal protein S7 0.0112135
VCAN versican 0.0109539
RNF217 ring finger protein 217 0.0108956
ERRFI1 ERBB receptor feedback inhibitor 1 0.0107083
NDFIP2 Nedd4 family interacting protein 2 0.0105391
SRRM2 serine/arginine repetitive matrix 2 0.0103669
TMSB4X thymosin beta 4, X-linked 0.0103314
TPM3 tropomyosin 3 0.0101986
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0101641
NABP1 nucleic acid binding protein 1 0.0100705
PARD3B par-3 family cell polarity regulator beta 0.0100574
GDA guanine deaminase 0.00991285
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.00978455
BIRC3 baculoviral IAP repeat containing 3 0.00977802
HBEGF heparin-binding EGF-like growth factor 0.00972745
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.00969372
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.00963846
SON SON DNA binding protein 0.00960105
WEE1 WEE1 G2 checkpoint kinase 0.00951704
RPS3A ribosomal protein S3A 0.00938024
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.00937422
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.00932776
WHRN whirlin 0.00927761
CDX2 caudal type homeobox 2 0.00914669
PTPRB protein tyrosine phosphatase, receptor type, B 0.00909025
EXT1 exostosin glycosyltransferase 1 0.00908371
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.00901442
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.00900676
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.00888371
RPS18 ribosomal protein S18 0.00881554
ARRDC3 arrestin domain containing 3 0.00875298
IFIH1 interferon induced with helicase C domain 1 0.00873665
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.00868636
SDF4 stromal cell derived factor 4 0.00865319
BBS9 Bardet-Biedl syndrome 9 0.00863153
MACROD2 MACRO domain containing 2 0.00862678
TBX3 T-box 3 0.00861399
SERTAD2 SERTA domain containing 2 0.0083367
CADPS2 Ca++-dependent secretion activator 2 0.00830751
RPL3 ribosomal protein L3 0.00830312
VEGFA vascular endothelial growth factor A 0.0082795
AEBP2 AE binding protein 2 0.00820256
AHNAK2 AHNAK nucleoprotein 2 0.00819935
CAMSAP1 calmodulin regulated spectrin-associated protein 1 0.00814841
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 0.00802112
FHIT fragile histidine triad 0.00795858

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.385329
PTMA prothymosin, alpha -0.219481
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.160689
TMSB10 thymosin beta 10 -0.147828
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0806923
RPS6 ribosomal protein S6 -0.0800155
NDRG1 N-myc downstream regulated 1 -0.0786614
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0747558
ANXA2 annexin A2 -0.0686871
ACTN4 actinin, alpha 4 -0.06531
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0651115
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0647475
RNF43 ring finger protein 43 -0.0599983
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0592437
TNS4 tensin 4 -0.0581471
GPHN gephyrin -0.0556077
RPLP1 ribosomal protein, large, P1 -0.0553664
RPL35A ribosomal protein L35a -0.0553301
VCL vinculin -0.0550756
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0517237
PKM pyruvate kinase, muscle -0.0500238
ITGA6 integrin, alpha 6 -0.0491038
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0485326
RPLP2 ribosomal protein, large, P2 -0.0475233
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0469868
RAB1A RAB1A, member RAS oncogene family -0.046877
NPSR1 neuropeptide S receptor 1 -0.0465873
RPS19 ribosomal protein S19 -0.0465076
ZFAND3 zinc finger, AN1-type domain 3 -0.0456216
DSCAM Down syndrome cell adhesion molecule -0.0455693
RPS23 ribosomal protein S23 -0.045266
PNISR PNN-interacting serine/arginine-rich protein -0.0447834
RPL34 ribosomal protein L34 -0.0444774
EZR ezrin -0.0441951
RBM39 RNA binding motif protein 39 -0.0440141
S100P S100 calcium binding protein P -0.0440079
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0436794
RPL23 ribosomal protein L23 -0.0435907
VMP1 vacuole membrane protein 1 -0.0425026
AREG amphiregulin -0.0421739
MED13L mediator complex subunit 13-like -0.0411774
PRELID2 PRELI domain containing 2 -0.0410187
S100A6 S100 calcium binding protein A6 -0.0409694
SETD5 SET domain containing 5 -0.0405523
INSIG1 insulin induced gene 1 -0.0398914
FAM13A family with sequence similarity 13, member A -0.03948
RPS24 ribosomal protein S24 -0.0394366
RPS29 ribosomal protein S29 -0.0392441
ACTG1 actin gamma 1 -0.0382115
ONECUT3 one cut homeobox 3 -0.0378154
FLNB filamin B, beta -0.0375779
ESYT2 extended synaptotagmin-like protein 2 -0.0369229
S100A10 S100 calcium binding protein A10 -0.0366505
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0365989
TPT1 tumor protein, translationally-controlled 1 -0.0364469
CD46 CD46 molecule, complement regulatory protein -0.0359158
NCOR1 nuclear receptor corepressor 1 -0.0358967
FTL ferritin, light polypeptide -0.0357757
ANKRD11 ankyrin repeat domain 11 -0.034947
S100A9 S100 calcium binding protein A9 -0.0348052
WAC WW domain containing adaptor with coiled-coil -0.0346561
WDR45B WD repeat domain 45B -0.0344682
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0342226
RPS11 ribosomal protein S11 -0.0339988
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0338756
SREBF2 sterol regulatory element binding transcription factor 2 -0.0337621
GLG1 golgi glycoprotein 1 -0.033654
EREG epiregulin -0.0333716
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0332872
ZNF292 zinc finger protein 292 -0.0332318
RPS25 ribosomal protein S25 -0.0331123
RNF145 ring finger protein 145 -0.0326822
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0326208
HMGA1 high mobility group AT-hook 1 -0.0324995
RPL36 ribosomal protein L36 -0.0324677
KMT2E lysine (K)-specific methyltransferase 2E -0.0324555
GOLGA4 golgin A4 -0.0323368
BIRC6 baculoviral IAP repeat containing 6 -0.0322626
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0318022
OGA O-GlcNAcase -0.0318019
PALLD palladin, cytoskeletal associated protein -0.0316583
PPARG peroxisome proliferator-activated receptor gamma -0.0315408
RPL28 ribosomal protein L28 -0.031523
RPL8 ribosomal protein L8 -0.0313425
KRT19 keratin 19, type I -0.0308418
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0305909
ANKRD17 ankyrin repeat domain 17 -0.0305733
CADPS Ca++-dependent secretion activator -0.0303915
NALF1 NALCN channel auxiliary factor 1 -0.0302741
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0300818
ITGB4 integrin, beta 4 -0.0300598
FNDC3B fibronectin type III domain containing 3B -0.0299981
RPL27A ribosomal protein L27a -0.0297999
GARS1 glycyl-tRNA synthetase 1 -0.0296617
POTEF POTE ankyrin domain family, member F -0.02961
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0295904
SBF2 SET binding factor 2 -0.0295838
SPAG9 sperm associated antigen 9 -0.0295392
MON2 MON2 homolog (S. cerevisiae) -0.0292986
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0292686