RMC-6236_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description RMC-6236 perturbation in LoVo cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the RMC-6236_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.0999381
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0770952
MYO1E myosin IE 0.0613738
DSPP dentin sialophosphoprotein 0.0542624
ZSWIM6 zinc finger, SWIM-type containing 6 0.0499687
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0460358
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0458527
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0441315
EEF2 eukaryotic translation elongation factor 2 0.0433715
HSPA8 heat shock 70kDa protein 8 0.0420542
EGFR epidermal growth factor receptor 0.0412276
RPL3 ribosomal protein L3 0.0357563
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0348519
LOC105378220 macrophage receptor MARCO-like 0.0307551
INTS6 integrator complex subunit 6 0.0305368
RPS18 ribosomal protein S18 0.0300866
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0297088
RACK1 receptor for activated C kinase 1 0.0276815
ITPRID2 ITPR interacting domain containing 2 0.026883
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0265487
KLF5 Kruppel-like factor 5 (intestinal) 0.0256858
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0252856
RIMKLB ribosomal modification protein rimK-like family member B 0.0247401
WWOX WW domain containing oxidoreductase 0.0237669
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.0236834
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0234172
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0231383
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0221277
ASPH aspartate beta-hydroxylase 0.0217768
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0206709
ERRFI1 ERBB receptor feedback inhibitor 1 0.0206419
CCSER1 coiled-coil serine-rich protein 1 0.020101
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0197561
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0195612
RPS2 ribosomal protein S2 0.0195215
CATSPERB catsper channel auxiliary subunit beta 0.0194545
UTRN utrophin 0.0194348
EXT1 exostosin glycosyltransferase 1 0.0193664
RPS12 ribosomal protein S12 0.0192818
SLTM SAFB-like, transcription modulator 0.0188457
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0181732
NABP1 nucleic acid binding protein 1 0.0180891
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0180683
PGM3 phosphoglucomutase 3 0.018036
ARRDC3 arrestin domain containing 3 0.0177967
AKAP13 A kinase (PRKA) anchor protein 13 0.0176222
PCBP2 poly(rC) binding protein 2 0.0174795
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0174494
LRRC23 leucine rich repeat containing 23 0.0173894
CADPS2 Ca++-dependent secretion activator 2 0.0170824
LDHA lactate dehydrogenase A 0.0170733
MACROD2 MACRO domain containing 2 0.0168304
MPRIP myosin phosphatase Rho interacting protein 0.0168145
PMM2 phosphomannomutase 2 0.0168009
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0166549
EEF1G eukaryotic translation elongation factor 1 gamma 0.0166227
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0165541
TMED3 transmembrane emp24 protein transport domain containing 3 0.0165046
CCNYL1 cyclin Y-like 1 0.016474
BBS9 Bardet-Biedl syndrome 9 0.0164722
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0164701
CTBP2 C-terminal binding protein 2 0.0163392
GOLGB1 golgin B1 0.0160539
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0159937
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0157833
SAMD5 sterile alpha motif domain containing 5 0.015709
SPON1 spondin 1, extracellular matrix protein 0.0156471
FAT1 FAT atypical cadherin 1 0.015197
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0151118
MYO5B myosin VB 0.0149074
PLEC plectin 0.0147323
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0145512
RPS3A ribosomal protein S3A 0.0144084
HSPH1 heat shock 105kDa/110kDa protein 1 0.0142646
PTPRB protein tyrosine phosphatase, receptor type, B 0.0142347
RPS17 ribosomal protein S17 0.0138042
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0136517
CXCL8 chemokine (C-X-C motif) ligand 8 0.0136453
RPS7 ribosomal protein S7 0.0134842
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0134143
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 0.0133724
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0133546
OSBPL10 oxysterol binding protein-like 10 0.0133313
BRD2 bromodomain containing 2 0.0130578
CCDC91 coiled-coil domain containing 91 0.0130476
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0130047
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0128451
APLP2 amyloid beta (A4) precursor-like protein 2 0.0128212
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0127884
RUNX1 runt-related transcription factor 1 0.012771
PLK2 polo-like kinase 2 0.0127024
EFNB2 ephrin-B2 0.0126629
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0125603
EIF5 eukaryotic translation initiation factor 5 0.0125233
PDLIM5 PDZ and LIM domain 5 0.0124472
SETX senataxin 0.0123818
AHNAK2 AHNAK nucleoprotein 2 0.0122882
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0122284
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0120133
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0119781

decreased expression

Symbol Name Standardized Value
EPS8 epidermal growth factor receptor pathway substrate 8 -0.210476
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.146423
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.114974
TMSB10 thymosin beta 10 -0.0908592
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0896683
PTMA prothymosin, alpha -0.0877015
CALB1 calbindin 1, 28kDa -0.0796771
RPLP1 ribosomal protein, large, P1 -0.0762669
THSD4 thrombospondin, type I, domain containing 4 -0.075664
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0745995
RPLP0 ribosomal protein, large, P0 -0.0713278
PLAC8 placenta-specific 8 -0.0704404
TPT1 tumor protein, translationally-controlled 1 -0.0684972
PTPRK protein tyrosine phosphatase, receptor type, K -0.0671171
FLNB filamin B, beta -0.0632079
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0622989
SHROOM3 shroom family member 3 -0.0590473
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0585044
MSI2 musashi RNA-binding protein 2 -0.058096
TRIM2 tripartite motif containing 2 -0.057147
RPS6 ribosomal protein S6 -0.0540206
GARS1 glycyl-tRNA synthetase 1 -0.0538622
P3H2 prolyl 3-hydroxylase 2 -0.0538384
TXNRD1 thioredoxin reductase 1 -0.0534252
ACTG1 actin gamma 1 -0.0531796
MKI67 marker of proliferation Ki-67 -0.0507824
GDF15 growth differentiation factor 15 -0.0494151
ITGA6 integrin, alpha 6 -0.0487723
ACTN4 actinin, alpha 4 -0.0485503
GMDS GDP-mannose 4,6-dehydratase -0.0480541
RIGI RNA sensor RIG-I -0.0458434
ATP10B ATPase, class V, type 10B -0.0455916
PCDHB16 protocadherin beta 16 -0.0453621
PKM pyruvate kinase, muscle -0.0438769
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0434004
VCL vinculin -0.0419444
RPL13A ribosomal protein L13a -0.0412476
RAP1B RAP1B, member of RAS oncogene family -0.0403849
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0403234
PKP2 plakophilin 2 -0.0389922
MYOF myoferlin -0.0386379
MUC13 mucin 13, cell surface associated -0.0385358
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0376959
PTPRR protein tyrosine phosphatase, receptor type, R -0.0373507
RPL27A ribosomal protein L27a -0.0370295
RPL35A ribosomal protein L35a -0.0370134
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0366238
EZR ezrin -0.03658
RPS29 ribosomal protein S29 -0.0364074
FOXP1 forkhead box P1 -0.0361805
KLF3 Kruppel-like factor 3 (basic) -0.0360306
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.03592
EIF1 eukaryotic translation initiation factor 1 -0.0358917
ANKRD11 ankyrin repeat domain 11 -0.0357886
PRSS3 protease, serine, 3 -0.0355975
FOXO1 forkhead box O1 -0.0354746
SMC4 structural maintenance of chromosomes 4 -0.035297
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0352761
RPL19 ribosomal protein L19 -0.0351548
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0348121
RPS21 ribosomal protein S21 -0.0347944
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0347594
TCF12 transcription factor 12 -0.0343805
ALCAM activated leukocyte cell adhesion molecule -0.0343455
YBX3 Y box binding protein 3 -0.0340211
ABHD17C abhydrolase domain containing 17C -0.0339749
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0338468
DSCAM Down syndrome cell adhesion molecule -0.0335811
RPS19 ribosomal protein S19 -0.0335475
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0332908
NT5C2 5'-nucleotidase, cytosolic II -0.0330725
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.0329225
DEK DEK proto-oncogene -0.0325042
CDC42SE2 CDC42 small effector 2 -0.0325023
SETD5 SET domain containing 5 -0.0323476
RBM39 RNA binding motif protein 39 -0.032288
GOLGA4 golgin A4 -0.0321853
RTN4 reticulon 4 -0.0320493
CENPF centromere protein F, 350/400kDa -0.031962
GCC2 GRIP and coiled-coil domain containing 2 -0.0317745
CXADR coxsackie virus and adenovirus receptor -0.0315717
RBM25 RNA binding motif protein 25 -0.0315291
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0312778
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0312757
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0312269
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0310701
RPS24 ribosomal protein S24 -0.0309501
RPS16 ribosomal protein S16 -0.0305778
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0305441
MYO1D myosin ID -0.0304638
MED13L mediator complex subunit 13-like -0.0303613
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0302934
ETNK1 ethanolamine kinase 1 -0.0301717
MON2 MON2 homolog (S. cerevisiae) -0.0301124
PPARG peroxisome proliferator-activated receptor gamma -0.029912
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0298262
PNISR PNN-interacting serine/arginine-rich protein -0.0298245
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0297386
MARCHF6 membrane associated ring-CH-type finger 6 -0.0295506
RPLP2 ribosomal protein, large, P2 -0.0293594