| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the RMC-6236_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TP63 | tumor protein p63 | 0.23812 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.174595 |
| MT2A | metallothionein 2A | 0.121842 |
| VIM | vimentin | 0.1075 |
| DST | dystonin | 0.107385 |
| HLA-B | major histocompatibility complex, class I, B | 0.100254 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0797956 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0787798 |
| B2M | beta-2-microglobulin | 0.0763524 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0756682 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0738879 |
| SP100 | SP100 nuclear antigen | 0.0725569 |
| RPS12 | ribosomal protein S12 | 0.0693951 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0673018 |
| FTL | ferritin, light polypeptide | 0.067095 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.067024 |
| CD44 | CD44 molecule (Indian blood group) | 0.063482 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0627953 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0621366 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0619498 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0617753 |
| TNS3 | tensin 3 | 0.0609982 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0609787 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0596647 |
| RNF213 | ring finger protein 213 | 0.0594498 |
| RPL12 | ribosomal protein L12 | 0.0588909 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0586173 |
| TMSB4X | thymosin beta 4, X-linked | 0.0585834 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0568754 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0564959 |
| COL5A2 | collagen, type V, alpha 2 | 0.0539663 |
| RPL26 | ribosomal protein L26 | 0.0502843 |
| RPS3 | ribosomal protein S3 | 0.0500673 |
| RPS8 | ribosomal protein S8 | 0.0500239 |
| EGFR | epidermal growth factor receptor | 0.0489212 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0477692 |
| RPL37A | ribosomal protein L37a | 0.0466658 |
| MYOF | myoferlin | 0.046413 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0460587 |
| RACK1 | receptor for activated C kinase 1 | 0.0450076 |
| MT1E | metallothionein 1E | 0.0444425 |
| PLSCR1 | phospholipid scramblase 1 | 0.0433089 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0425535 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0416226 |
| EPHA4 | EPH receptor A4 | 0.0396512 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0391178 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0388418 |
| RPL31 | ribosomal protein L31 | 0.0371205 |
| MT1X | metallothionein 1X | 0.0371032 |
| ADAR | adenosine deaminase, RNA-specific | 0.0369392 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0366914 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0363366 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0362282 |
| HLA-E | major histocompatibility complex, class I, E | 0.0351715 |
| HLA-A | major histocompatibility complex, class I, A | 0.0350794 |
| CFB | complement factor B | 0.0349515 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0348903 |
| ENO1 | enolase 1, (alpha) | 0.0348371 |
| SQSTM1 | sequestosome 1 | 0.0343914 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0343279 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0341646 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0340614 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0328367 |
| RPL37 | ribosomal protein L37 | 0.0323629 |
| RPL36 | ribosomal protein L36 | 0.0315865 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0310133 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0306813 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0286995 |
| RPL35A | ribosomal protein L35a | 0.0283344 |
| SFTPA2 | surfactant protein A2 | 0.027798 |
| TRIM56 | tripartite motif containing 56 | 0.0277262 |
| PLIN2 | perilipin 2 | 0.0275123 |
| RPS6 | ribosomal protein S6 | 0.0273333 |
| TPI1 | triosephosphate isomerase 1 | 0.0269304 |
| DNER | delta/notch-like EGF repeat containing | 0.0268772 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0267221 |
| RPS27 | ribosomal protein S27 | 0.0266389 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0261308 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0259824 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0258242 |
| TXNIP | thioredoxin interacting protein | 0.0255641 |
| HDAC9 | histone deacetylase 9 | 0.0253961 |
| RPS2 | ribosomal protein S2 | 0.025232 |
| OPTN | optineurin | 0.0251887 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0251061 |
| PMP22 | peripheral myelin protein 22 | 0.0247764 |
| APOLD1 | apolipoprotein L domain containing 1 | 0.0242912 |
| RPS19 | ribosomal protein S19 | 0.0241565 |
| TGM2 | transglutaminase 2 | 0.0241491 |
| LYST | lysosomal trafficking regulator | 0.0240785 |
| AEBP2 | AE binding protein 2 | 0.0240273 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0237666 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.0236703 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0236658 |
| RIGI | RNA sensor RIG-I | 0.0233815 |
| RPL27 | ribosomal protein L27 | 0.0232237 |
| GOLGB1 | golgin B1 | 0.0222541 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0221269 |
| PRELID2 | PRELI domain containing 2 | 0.0215311 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0214647 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.265864 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.156749 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.141455 |
| TXNRD1 | thioredoxin reductase 1 | -0.101262 |
| PTMA | prothymosin, alpha | -0.0800829 |
| RAI1 | retinoic acid induced 1 | -0.0676522 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0611164 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0605705 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0604937 |
| RTN4 | reticulon 4 | -0.0601435 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0543313 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0525018 |
| TMEM41B | transmembrane protein 41B | -0.0488645 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0481762 |
| TOP1 | topoisomerase (DNA) I | -0.0431942 |
| SRPK2 | SRSF protein kinase 2 | -0.0429382 |
| JMJD1C | jumonji domain containing 1C | -0.0425854 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.041095 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0399243 |
| FBXO11 | F-box protein 11 | -0.0394 |
| ANKRD11 | ankyrin repeat domain 11 | -0.039143 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0383199 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0379171 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0379129 |
| CENPF | centromere protein F, 350/400kDa | -0.0377127 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0372635 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0371408 |
| EGR1 | early growth response 1 | -0.0367123 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0366467 |
| ACTG1 | actin gamma 1 | -0.0348593 |
| USP34 | ubiquitin specific peptidase 34 | -0.0348385 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0345138 |
| RBM39 | RNA binding motif protein 39 | -0.033207 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.033153 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.032663 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0325643 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0324886 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0323911 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0323077 |
| SBF2 | SET binding factor 2 | -0.0322944 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0312504 |
| MKI67 | marker of proliferation Ki-67 | -0.0311209 |
| EZR | ezrin | -0.0302845 |
| FLNB | filamin B, beta | -0.0295375 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0295146 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0293662 |
| NUP58 | nucleoporin 58 | -0.0293553 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0292466 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0292461 |
| WDR45B | WD repeat domain 45B | -0.0290323 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0290216 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0290187 |
| ECT2 | epithelial cell transforming 2 | -0.028844 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0286758 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0285133 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0284125 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0280878 |
| PYGB | phosphorylase, glycogen; brain | -0.0280398 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0277604 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0276623 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0275769 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0273563 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0268147 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0268014 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0267086 |
| CEP170 | centrosomal protein 170kDa | -0.0266902 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0264926 |
| TAOK1 | TAO kinase 1 | -0.0264072 |
| SMC4 | structural maintenance of chromosomes 4 | -0.026401 |
| EMP1 | epithelial membrane protein 1 | -0.0260901 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0260535 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0259968 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0256775 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0255933 |
| ANLN | anillin, actin binding protein | -0.0255713 |
| FOXJ3 | forkhead box J3 | -0.0254028 |
| WDR26 | WD repeat domain 26 | -0.0253136 |
| COG5 | component of oligomeric golgi complex 5 | -0.0251429 |
| FUS | FUS RNA binding protein | -0.0251112 |
| DIAPH3 | diaphanous-related formin 3 | -0.0249911 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0249781 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0249196 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0246893 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.024585 |
| NF1 | neurofibromin 1 | -0.0245602 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0245276 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0243735 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0242023 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0241621 |
| CAPRIN2 | caprin family member 2 | -0.0241016 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0240988 |
| NHSL1 | NHS-like 1 | -0.0240935 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0238331 |
| TPX2 | TPX2, microtubule-associated | -0.0237186 |
| ZNF207 | zinc finger protein 207 | -0.0235891 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0235203 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0234825 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0231381 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0230778 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0229042 |
