| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the RMC-6236_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.180238 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.149487 |
| PCBP2 | poly(rC) binding protein 2 | 0.095723 |
| SMAD3 | SMAD family member 3 | 0.0806612 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0565839 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0556311 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0554183 |
| B2M | beta-2-microglobulin | 0.0540715 |
| IFI44L | interferon-induced protein 44-like | 0.0496901 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0493232 |
| VIM | vimentin | 0.0490839 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0458079 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0410169 |
| RPS12 | ribosomal protein S12 | 0.0409364 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0396942 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0388556 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0370308 |
| VEGFA | vascular endothelial growth factor A | 0.0360064 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0359162 |
| PLIN2 | perilipin 2 | 0.0358666 |
| SP100 | SP100 nuclear antigen | 0.0349995 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0347582 |
| ANGPTL4 | angiopoietin-like 4 | 0.0347163 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0346845 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0342006 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0339297 |
| IL1R1 | interleukin 1 receptor, type I | 0.0339085 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.032452 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0311847 |
| GATA6 | GATA binding protein 6 | 0.0300187 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0299081 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0295924 |
| RUNX1 | runt-related transcription factor 1 | 0.0288727 |
| MT2A | metallothionein 2A | 0.0280137 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.027684 |
| EREG | epiregulin | 0.026656 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0265206 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0263023 |
| SFTPA2 | surfactant protein A2 | 0.0258919 |
| RPS3 | ribosomal protein S3 | 0.0250251 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0247873 |
| RACK1 | receptor for activated C kinase 1 | 0.0244268 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0243084 |
| TMSB4X | thymosin beta 4, X-linked | 0.0241941 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0241463 |
| CFB | complement factor B | 0.0241307 |
| ENO1 | enolase 1, (alpha) | 0.0230168 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.022968 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.022953 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0228835 |
| MX1 | MX dynamin-like GTPase 1 | 0.0227785 |
| ARRDC3 | arrestin domain containing 3 | 0.0226931 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0226902 |
| RPS8 | ribosomal protein S8 | 0.0226752 |
| NTN4 | netrin 4 | 0.0223459 |
| LDHA | lactate dehydrogenase A | 0.0221414 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0219606 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0219007 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0210243 |
| RPS19 | ribosomal protein S19 | 0.020327 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | 0.0202409 |
| RAD51B | RAD51 paralog B | 0.0202311 |
| ADM | adrenomedullin | 0.0201493 |
| AADAC | arylacetamide deacetylase | 0.0200122 |
| IFI44 | interferon-induced protein 44 | 0.019477 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0193659 |
| C1R | complement component 1, r subcomponent | 0.0193387 |
| RPL12 | ribosomal protein L12 | 0.0190455 |
| RPS17 | ribosomal protein S17 | 0.0190233 |
| CTSC | cathepsin C | 0.0186854 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0186077 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0184044 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0181435 |
| ADAR | adenosine deaminase, RNA-specific | 0.0175113 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0168177 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0166116 |
| RPL18 | ribosomal protein L18 | 0.0165728 |
| ECE1 | endothelin converting enzyme 1 | 0.0165606 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0165343 |
| RPS2 | ribosomal protein S2 | 0.0164245 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0163073 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0162259 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0161558 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0161153 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.016072 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0159882 |
| SSH1 | slingshot protein phosphatase 1 | 0.0159792 |
| TPI1 | triosephosphate isomerase 1 | 0.015852 |
| MMP2 | matrix metallopeptidase 2 | 0.0158308 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0157701 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0153692 |
| H1-0 | H1.0 linker histone | 0.0152646 |
| KIF5B | kinesin family member 5B | 0.0151268 |
| RNF213 | ring finger protein 213 | 0.0150174 |
| RPL37 | ribosomal protein L37 | 0.0149921 |
| KSR1 | kinase suppressor of ras 1 | 0.0148436 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0146684 |
| MX2 | MX dynamin-like GTPase 2 | 0.0143758 |
| PMP22 | peripheral myelin protein 22 | 0.0142235 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0141632 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.113368 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0868291 |
| CDH13 | cadherin 13 | -0.0845598 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0828508 |
| FN1 | fibronectin 1 | -0.0815748 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0798483 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0778578 |
| GLCCI1 | glucocorticoid induced 1 | -0.0710047 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0688278 |
| TMSB10 | thymosin beta 10 | -0.0688198 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.067144 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0667965 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0661303 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0653674 |
| MTSS1 | metastasis suppressor 1 | -0.0608988 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0598726 |
| HMGA2 | high mobility group AT-hook 2 | -0.0571715 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.055678 |
| RBM39 | RNA binding motif protein 39 | -0.0546563 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0508071 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0502644 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0497951 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0486723 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0485768 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0484608 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0484324 |
| JMJD1C | jumonji domain containing 1C | -0.048084 |
| USP34 | ubiquitin specific peptidase 34 | -0.0480068 |
| NRP1 | neuropilin 1 | -0.0443544 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0436334 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0430812 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0429582 |
| NUMB | numb homolog (Drosophila) | -0.0425116 |
| EGR1 | early growth response 1 | -0.040696 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0402126 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0400957 |
| OSMR | oncostatin M receptor | -0.0400446 |
| NRG1 | neuregulin 1 | -0.0398704 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0398481 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0391268 |
| MEF2A | myocyte enhancer factor 2A | -0.0389299 |
| VMP1 | vacuole membrane protein 1 | -0.0385005 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0383084 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0382544 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0376161 |
| CDK14 | cyclin-dependent kinase 14 | -0.037162 |
| FAM20C | family with sequence similarity 20, member C | -0.0367775 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0363644 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0355685 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0352708 |
| OXSR1 | oxidative stress responsive 1 | -0.0352235 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0346439 |
| CALU | calumenin | -0.0334204 |
| CLIC4 | chloride intracellular channel 4 | -0.0333411 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0328016 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.032532 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0325047 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0321177 |
| GPC6 | glypican 6 | -0.0320714 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0320331 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0317945 |
| LOX | lysyl oxidase | -0.0309306 |
| HM13 | histocompatibility (minor) 13 | -0.0306828 |
| SPAG9 | sperm associated antigen 9 | -0.0306826 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0305053 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0304663 |
| STC1 | stanniocalcin 1 | -0.0295979 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0291916 |
| SETD5 | SET domain containing 5 | -0.0289421 |
| TMEM165 | transmembrane protein 165 | -0.0287831 |
| DNER | delta/notch-like EGF repeat containing | -0.028673 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.028442 |
| GOLGA4 | golgin A4 | -0.0283935 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.028306 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0282331 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.027952 |
| TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | -0.0278476 |
| TMEM263 | transmembrane protein 263 | -0.0274266 |
| RAI14 | retinoic acid induced 14 | -0.0271628 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0271381 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0269915 |
| PTMA | prothymosin, alpha | -0.0268674 |
| DENND4A | DENN/MADD domain containing 4A | -0.0267946 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0267564 |
| PRELID2 | PRELI domain containing 2 | -0.0267445 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0266786 |
| FBXO11 | F-box protein 11 | -0.0266549 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0265691 |
| PYGL | phosphorylase, glycogen, liver | -0.0264981 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0264937 |
| EFNA5 | ephrin-A5 | -0.0264901 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0264036 |
| HDLBP | high density lipoprotein binding protein | -0.0263099 |
| CLMP | CXADR-like membrane protein | -0.0262561 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0259698 |
| SEC24D | SEC24 family member D | -0.025903 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.025898 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0258775 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0258153 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0257649 |
