| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the RMC-6236_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.098284 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0954778 |
| MT2A | metallothionein 2A | 0.0842307 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.071113 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.068054 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0614351 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.054704 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0503902 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0486791 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0428642 |
| WWOX | WW domain containing oxidoreductase | 0.0409684 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0405255 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0397687 |
| IL6 | interleukin 6 | 0.039498 |
| EZR | ezrin | 0.0359908 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0338376 |
| ATXN1 | ataxin 1 | 0.0320714 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0312714 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0309869 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0308367 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0302922 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0301342 |
| SFTPA2 | surfactant protein A2 | 0.029831 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0291176 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0288539 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0287243 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0285864 |
| NDRG1 | N-myc downstream regulated 1 | 0.0285776 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0266849 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0262731 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0257925 |
| FLNB | filamin B, beta | 0.0250993 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0249199 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0248486 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0248261 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0241114 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0240403 |
| KIAA0319 | KIAA0319 | 0.0239973 |
| RPLP1 | ribosomal protein, large, P1 | 0.0234336 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.023321 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0229099 |
| SQSTM1 | sequestosome 1 | 0.0226838 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0224343 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0219488 |
| GOLGB1 | golgin B1 | 0.0218681 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.021773 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0217221 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0217216 |
| RPS6 | ribosomal protein S6 | 0.0213327 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.02099 |
| PRELID2 | PRELI domain containing 2 | 0.0201166 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0196705 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0194687 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0194662 |
| HLA-E | major histocompatibility complex, class I, E | 0.0194339 |
| FN1 | fibronectin 1 | 0.0194212 |
| JUN | jun proto-oncogene | 0.0193634 |
| PLEC | plectin | 0.0192949 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0191563 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.018965 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0188193 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0184088 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0182763 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0181901 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0178426 |
| GOLGA4 | golgin A4 | 0.0177723 |
| NBEAL1 | neurobeachin-like 1 | 0.0177561 |
| HLA-B | major histocompatibility complex, class I, B | 0.017711 |
| IER3 | immediate early response 3 | 0.0171778 |
| CLIC4 | chloride intracellular channel 4 | 0.0170424 |
| AHNAK | AHNAK nucleoprotein | 0.016809 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.016757 |
| ANXA1 | annexin A1 | 0.0166057 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0164172 |
| DSE | dermatan sulfate epimerase | 0.0163573 |
| PYGL | phosphorylase, glycogen, liver | 0.0161216 |
| OPTN | optineurin | 0.0160373 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0160038 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0158691 |
| LAMC2 | laminin, gamma 2 | 0.0158579 |
| CYP20A1 | cytochrome P450, family 20, subfamily A, polypeptide 1 | 0.0156631 |
| MLF1 | myeloid leukemia factor 1 | 0.0155267 |
| DSPP | dentin sialophosphoprotein | 0.0155144 |
| CD44 | CD44 molecule (Indian blood group) | 0.0154907 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0154849 |
| JMJD1C | jumonji domain containing 1C | 0.0153649 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0153317 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0152842 |
| USP53 | ubiquitin specific peptidase 53 | 0.0151352 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0149824 |
| ITGAV | integrin, alpha V | 0.014924 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0148646 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0147842 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0147282 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0146478 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0145787 |
| MCL1 | myeloid cell leukemia 1 | 0.0144347 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | 0.0144346 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0143562 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0143461 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.137239 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.131951 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.102805 |
| SLC38A2 | solute carrier family 38, member 2 | -0.101752 |
| FTL | ferritin, light polypeptide | -0.0934003 |
| TMSB10 | thymosin beta 10 | -0.0884216 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0872359 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0781881 |
| TXNRD1 | thioredoxin reductase 1 | -0.0710889 |
| GRAMD1B | GRAM domain containing 1B | -0.0660019 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0659259 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0637752 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0632516 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.059598 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0592939 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0540172 |
| WDR43 | WD repeat domain 43 | -0.0537456 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0536623 |
| IGF2 | insulin-like growth factor 2 | -0.0526243 |
| NEGR1 | neuronal growth regulator 1 | -0.0523932 |
| ERBIN | erbb2 interacting protein | -0.0520992 |
| HDAC9 | histone deacetylase 9 | -0.0520675 |
| EGR1 | early growth response 1 | -0.0519406 |
| PFN1 | profilin 1 | -0.0519152 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0493036 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0471038 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0470118 |
| BICC1 | BicC family RNA binding protein 1 | -0.0462363 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0444851 |
| LDHA | lactate dehydrogenase A | -0.0444282 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0443814 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0431671 |
| PTK2 | protein tyrosine kinase 2 | -0.0405452 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0404772 |
| HMGA1 | high mobility group AT-hook 1 | -0.0391735 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0381306 |
| DENND4A | DENN/MADD domain containing 4A | -0.0373502 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0368617 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0360226 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0359927 |
| UTRN | utrophin | -0.0358681 |
| PKM | pyruvate kinase, muscle | -0.0358523 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0342327 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0337916 |
| ACTG1 | actin gamma 1 | -0.033342 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0332201 |
| STC1 | stanniocalcin 1 | -0.0332182 |
| ECT2 | epithelial cell transforming 2 | -0.0328824 |
| PCNX4 | pecanex 4 | -0.0327109 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0326433 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0323391 |
| POTEF | POTE ankyrin domain family, member F | -0.0322861 |
| RHOA | ras homolog family member A | -0.0319405 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0319049 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0318787 |
| RASAL2 | RAS protein activator like 2 | -0.0318525 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0314737 |
| HMGA2 | high mobility group AT-hook 2 | -0.031156 |
| EFNA5 | ephrin-A5 | -0.0310052 |
| SMAD2 | SMAD family member 2 | -0.0305953 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0296406 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0295962 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0295867 |
| USP34 | ubiquitin specific peptidase 34 | -0.0291409 |
| RPL19 | ribosomal protein L19 | -0.0288908 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0287858 |
| THBS1 | thrombospondin 1 | -0.0287847 |
| RTN4 | reticulon 4 | -0.0285377 |
| VIM | vimentin | -0.0283403 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0280437 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0279419 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0279185 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0278467 |
| TMEM131 | transmembrane protein 131 | -0.0278277 |
| RPLP0 | ribosomal protein, large, P0 | -0.0275932 |
| KYNU | kynureninase | -0.0275821 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0272543 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.026998 |
| WBP11 | WW domain binding protein 11 | -0.0268047 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0266555 |
| TBC1D5 | TBC1 domain family, member 5 | -0.026536 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0264877 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0260616 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0260503 |
| NAV3 | neuron navigator 3 | -0.0259936 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0259693 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0259156 |
| CCNL1 | cyclin L1 | -0.0259071 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.02582 |
| NRG1 | neuregulin 1 | -0.0257337 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0253964 |
| BMPR1B | bone morphogenetic protein receptor, type IB | -0.0252513 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0252058 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0251645 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.024912 |
| GLIS3 | GLIS family zinc finger 3 | -0.024761 |
| CHN1 | chimerin 1 | -0.0247071 |
| RHEB | Ras homolog enriched in brain | -0.0245141 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0244278 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0241363 |
