RMC-6236_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description RMC-6236 perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the RMC-6236_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KRT17 keratin 17, type I 0.178219
PDE4D phosphodiesterase 4D, cAMP-specific 0.168372
LIMCH1 LIM and calponin homology domains 1 0.139473
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.123871
KYNU kynureninase 0.122414
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.114751
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.106339
MAST4 microtubule associated serine/threonine kinase family member 4 0.0983647
ASPH aspartate beta-hydroxylase 0.0922751
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0865176
ERRFI1 ERBB receptor feedback inhibitor 1 0.0861878
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0779732
IFIH1 interferon induced with helicase C domain 1 0.0777571
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0768695
EFNA5 ephrin-A5 0.0735977
SMYD3 SET and MYND domain containing 3 0.0721577
DOCK4 dedicator of cytokinesis 4 0.0712056
JAK2 Janus kinase 2 0.0685811
LDHA lactate dehydrogenase A 0.0680561
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0673651
MYO1E myosin IE 0.0664852
ZNF292 zinc finger protein 292 0.0649922
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0647615
BACE2 beta-site APP-cleaving enzyme 2 0.0631559
NPEPPS aminopeptidase puromycin sensitive 0.0626826
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0621889
SFTPA2 surfactant protein A2 0.0601326
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0578671
PLCB4 phospholipase C, beta 4 0.0574448
PLAUR plasminogen activator, urokinase receptor 0.0569818
LSAMP limbic system-associated membrane protein 0.0569205
RPS6 ribosomal protein S6 0.0560868
IGFBP3 insulin-like growth factor binding protein 3 0.055018
FER fer (fps/fes related) tyrosine kinase 0.0535502
CSNK1A1 casein kinase 1, alpha 1 0.0528301
CTNND1 catenin (cadherin-associated protein), delta 1 0.051536
MYO5B myosin VB 0.0509333
ADARB1 adenosine deaminase, RNA-specific, B1 0.0505954
SORBS2 sorbin and SH3 domain containing 2 0.0503771
SMOC1 SPARC related modular calcium binding 1 0.0481633
MYOF myoferlin 0.0481541
FNIP1 folliculin interacting protein 1 0.0473548
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0470412
LINGO2 leucine rich repeat and Ig domain containing 2 0.0470388
NKD1 naked cuticle homolog 1 (Drosophila) 0.046832
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0462106
ANO6 anoctamin 6 0.0460923
METAP2 methionyl aminopeptidase 2 0.0454728
DST dystonin 0.044764
RPS3 ribosomal protein S3 0.0443664
TRIP12 thyroid hormone receptor interactor 12 0.0442929
RBM47 RNA binding motif protein 47 0.044163
AFF1 AF4/FMR2 family, member 1 0.0434287
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0433998
ATXN1 ataxin 1 0.0433573
CPNE1 copine I 0.0431681
NAMPT nicotinamide phosphoribosyltransferase 0.042693
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0423152
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0422341
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0415732
OASL 2'-5'-oligoadenylate synthetase-like 0.0413284
FTH1 ferritin, heavy polypeptide 1 0.0411313
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0403588
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.040195
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0400086
CATSPERB catsper channel auxiliary subunit beta 0.0398636
PUM2 pumilio RNA-binding family member 2 0.039716
RPS24 ribosomal protein S24 0.0388925
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0388056
F3 coagulation factor III (thromboplastin, tissue factor) 0.038635
MICU1 mitochondrial calcium uptake 1 0.0380159
SRRM2 serine/arginine repetitive matrix 2 0.0379957
UBE2H ubiquitin-conjugating enzyme E2H 0.0376497
WIPF2 WAS/WASL interacting protein family, member 2 0.0375291
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 0.0372103
RAD51B RAD51 paralog B 0.0367715
RSL1D1 ribosomal L1 domain containing 1 0.0367266
AHR aryl hydrocarbon receptor 0.0366749
KRT7 keratin 7, type II 0.0365031
IGF2 insulin-like growth factor 2 0.0364621
HSPH1 heat shock 105kDa/110kDa protein 1 0.0364575
PDLIM5 PDZ and LIM domain 5 0.0363524
RACK1 receptor for activated C kinase 1 0.0362085
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0359841
SQSTM1 sequestosome 1 0.0354716
YTHDC1 YTH domain containing 1 0.0354237
DGKD diacylglycerol kinase, delta 130kDa 0.0353615
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.0337517
PHGDH phosphoglycerate dehydrogenase 0.0335047
MSN moesin 0.0333098
CEP350 centrosomal protein 350kDa 0.033275
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0328972
ZNFX1 zinc finger, NFX1-type containing 1 0.0328334
FHIT fragile histidine triad 0.0321274
MACF1 microtubule-actin crosslinking factor 1 0.0320783
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0320236
JMJD1C jumonji domain containing 1C 0.0319777
STEAP4 STEAP family member 4 0.0313679
AOPEP aminopeptidase O (putative) 0.0312339
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0311317

decreased expression

Symbol Name Standardized Value
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0773847
LAMC2 laminin, gamma 2 -0.0762482
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0742988
ATOSA atos homolog A -0.0719015
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0693114
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.067543
KIF13B kinesin family member 13B -0.066761
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0665111
CEMIP cell migration inducing protein, hyaluronan binding -0.061109
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0574128
MYO6 myosin VI -0.0547631
SPNS2 spinster homolog 2 (Drosophila) -0.0545457
PTMA prothymosin, alpha -0.0539589
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0533436
PTPRM protein tyrosine phosphatase, receptor type, M -0.0522453
SBF2 SET binding factor 2 -0.0498906
CCNL1 cyclin L1 -0.0478395
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0452331
BBX bobby sox homolog (Drosophila) -0.0451888
ZNF185 zinc finger protein 185 (LIM domain) -0.0446726
SHB Src homology 2 domain containing adaptor protein B -0.0439982
BIRC6 baculoviral IAP repeat containing 6 -0.0429218
TMPRSS4 transmembrane protease, serine 4 -0.0429167
CD59 CD59 molecule, complement regulatory protein -0.0428069
IRAK2 interleukin-1 receptor-associated kinase 2 -0.0425142
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0419777
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0416379
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0416215
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0414635
SAMD12 sterile alpha motif domain containing 12 -0.0412096
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0410584
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma -0.0405939
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0403586
TJP2 tight junction protein 2 -0.0399966
WSB1 WD repeat and SOCS box containing 1 -0.0398915
ITCH itchy E3 ubiquitin protein ligase -0.0396298
PTK2 protein tyrosine kinase 2 -0.039498
SP100 SP100 nuclear antigen -0.0394479
ZNF638 zinc finger protein 638 -0.0393446
DENND1A DENN/MADD domain containing 1A -0.0392392
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0388421
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0386365
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough -0.0384494
ANKRD36C ankyrin repeat domain 36C -0.0379207
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0379042
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0375815
GCC2 GRIP and coiled-coil domain containing 2 -0.0375003
ESYT2 extended synaptotagmin-like protein 2 -0.037065
WASF2 WAS protein family, member 2 -0.0370504
SLMAP sarcolemma associated protein -0.0370392
MXD1 MAX dimerization protein 1 -0.0369103
RTN4 reticulon 4 -0.0363608
TNRC18 trinucleotide repeat containing 18 -0.0360825
ANKRD11 ankyrin repeat domain 11 -0.0360536
PHIP pleckstrin homology domain interacting protein -0.0352959
NCOR1 nuclear receptor corepressor 1 -0.0347143
DOCK9 dedicator of cytokinesis 9 -0.0346652
NCOR2 nuclear receptor corepressor 2 -0.0346437
ANTXR2 anthrax toxin receptor 2 -0.0344288
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0342859
SCEL sciellin -0.0339238
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.0338787
FOSL2 FOS-like antigen 2 -0.0336079
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0335014
DUSP5 dual specificity phosphatase 5 -0.0333287
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0332385
USP8 ubiquitin specific peptidase 8 -0.0331429
TTC3 tetratricopeptide repeat domain 3 -0.0330757
KDM7A lysine (K)-specific demethylase 7A -0.0327267
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0325534
GOLM2 golgi membrane protein 2 -0.0325305
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.032513
ACIN1 apoptotic chromatin condensation inducer 1 -0.0324975
MATR3 matrin 3 -0.0324972
KDM2A lysine (K)-specific demethylase 2A -0.0319426
GMDS GDP-mannose 4,6-dehydratase -0.0316485
TPM4 tropomyosin 4 -0.03161
NPTN neuroplastin -0.0315647
SNX9 sorting nexin 9 -0.0313348
GNAS GNAS complex locus -0.031063
CLTC clathrin, heavy chain (Hc) -0.0307796
MYO10 myosin X -0.0307115
EGFR epidermal growth factor receptor -0.0306056
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0305645
TMEM87A transmembrane protein 87A -0.0305569
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0305251
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0304257
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0303387
ACTN4 actinin, alpha 4 -0.0302927
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0302215
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.0301392
MIS18BP1 MIS18 binding protein 1 -0.0300847
MARCHF6 membrane associated ring-CH-type finger 6 -0.0297957
DICER1 dicer 1, ribonuclease type III -0.0297768
PARD3 par-3 family cell polarity regulator -0.029537
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0292634
ATP13A3 ATPase type 13A3 -0.029082
MEF2A myocyte enhancer factor 2A -0.0290305
SCFD1 sec1 family domain containing 1 -0.0289993
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0289771