RMC-6236_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description RMC-6236 perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the RMC-6236_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.207906
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.166188
TXNRD1 thioredoxin reductase 1 0.113656
EEF2 eukaryotic translation elongation factor 2 0.102304
IFI6 interferon, alpha-inducible protein 6 0.0887116
VIM vimentin 0.085049
TPI1 triosephosphate isomerase 1 0.081567
KTN1 kinectin 1 (kinesin receptor) 0.0797034
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0761025
RPS3 ribosomal protein S3 0.0735537
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0702348
RPS8 ribosomal protein S8 0.0642663
RPL37 ribosomal protein L37 0.0588721
ADAR adenosine deaminase, RNA-specific 0.0568791
RPL26 ribosomal protein L26 0.0553507
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0545732
RPL37A ribosomal protein L37a 0.0531842
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0531014
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0520289
IGF1R insulin-like growth factor 1 receptor 0.0506785
RPS12 ribosomal protein S12 0.0503883
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0502401
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0486366
DSPP dentin sialophosphoprotein 0.0463755
BMP5 bone morphogenetic protein 5 0.0452957
RPL12 ribosomal protein L12 0.0451213
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0444375
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0443025
ENO1 enolase 1, (alpha) 0.0436401
SFTPA2 surfactant protein A2 0.043104
SNAP25 synaptosomal-associated protein, 25kDa 0.0420956
RPS4X ribosomal protein S4, X-linked 0.0419408
B2M beta-2-microglobulin 0.0412377
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0409458
RPS27A ribosomal protein S27a 0.0407985
RPLP1 ribosomal protein, large, P1 0.0385827
RPS19 ribosomal protein S19 0.0385634
HLA-B major histocompatibility complex, class I, B 0.0385509
RPL11 ribosomal protein L11 0.0382069
FTH1 ferritin, heavy polypeptide 1 0.0381436
PDE10A phosphodiesterase 10A 0.0377617
RACK1 receptor for activated C kinase 1 0.0374703
RPS27 ribosomal protein S27 0.0374358
ELL2 elongation factor, RNA polymerase II, 2 0.037158
RPL23 ribosomal protein L23 0.0367036
TMSB10 thymosin beta 10 0.035859
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0358572
RPS2 ribosomal protein S2 0.034771
PTMA prothymosin, alpha 0.0343459
NFE2L2 nuclear factor, erythroid 2-like 2 0.0343356
RPS17 ribosomal protein S17 0.0339628
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0335562
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.032907
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.032564
MYH9 myosin, heavy chain 9, non-muscle 0.032457
ERRFI1 ERBB receptor feedback inhibitor 1 0.0324243
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0320932
RPL35A ribosomal protein L35a 0.0319008
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0316131
HSPA8 heat shock 70kDa protein 8 0.031321
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0309387
RPS6 ribosomal protein S6 0.0304014
GOLGB1 golgin B1 0.0302144
YBX1 Y box binding protein 1 0.0301399
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0300962
GABARAPL1 GABA(A) receptor-associated protein like 1 0.0284208
RPL31 ribosomal protein L31 0.0279735
BRD2 bromodomain containing 2 0.0277556
CCDC200 coiled-coil domain containing 200 0.0275514
ZNFX1 zinc finger, NFX1-type containing 1 0.0273285
SRRM2 serine/arginine repetitive matrix 2 0.0272782
CXADR coxsackie virus and adenovirus receptor 0.0271768
RPL27 ribosomal protein L27 0.0266786
DSCAM Down syndrome cell adhesion molecule 0.0266448
AHNAK AHNAK nucleoprotein 0.0266244
DST dystonin 0.0264948
RPL34 ribosomal protein L34 0.0262502
NAP1L1 nucleosome assembly protein 1-like 1 0.0260715
MBNL2 muscleblind-like splicing regulator 2 0.0258014
RPS7 ribosomal protein S7 0.0256855
UBC ubiquitin C 0.0256734
ZSWIM6 zinc finger, SWIM-type containing 6 0.0256647
ANXA2 annexin A2 0.0256607
DUSP16 dual specificity phosphatase 16 0.0253707
PCBP2 poly(rC) binding protein 2 0.0246009
RPL36 ribosomal protein L36 0.0244262
RPL5 ribosomal protein L5 0.024002
RPLP2 ribosomal protein, large, P2 0.0239777
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0237725
RPL19 ribosomal protein L19 0.0235358
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0234354
TPM3 tropomyosin 3 0.0229686
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0229451
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0229021
USP9X ubiquitin specific peptidase 9, X-linked 0.0227801
IFIH1 interferon induced with helicase C domain 1 0.0227245
EEF1G eukaryotic translation elongation factor 1 gamma 0.0225776
SQSTM1 sequestosome 1 0.022521
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0222945
LRP1B low density lipoprotein receptor-related protein 1B 0.0221047

decreased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B -0.156846
EGR1 early growth response 1 -0.106638
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0988499
THSD4 thrombospondin, type I, domain containing 4 -0.0868692
AFF3 AF4/FMR2 family, member 3 -0.0786717
MCL1 myeloid cell leukemia 1 -0.0746282
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0717153
PTK2 protein tyrosine kinase 2 -0.0691207
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0669244
NF1 neurofibromin 1 -0.0658357
USP34 ubiquitin specific peptidase 34 -0.0601159
HMGA2 high mobility group AT-hook 2 -0.0589144
NABP1 nucleic acid binding protein 1 -0.0586198
BIRC6 baculoviral IAP repeat containing 6 -0.05706
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0561929
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0561071
CCNL1 cyclin L1 -0.05503
TAS2R14 taste receptor, type 2, member 14 -0.0502055
BBX bobby sox homolog (Drosophila) -0.0496836
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0464328
SBF2 SET binding factor 2 -0.046116
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0455315
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0454227
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0447538
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0440107
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0405837
LRPPRC leucine-rich pentatricopeptide repeat containing -0.040441
FMNL2 formin-like 2 -0.0385201
RSF1 remodeling and spacing factor 1 -0.0381412
COPA coatomer protein complex, subunit alpha -0.037513
RYR3 ryanodine receptor 3 -0.0373265
EML4 echinoderm microtubule associated protein like 4 -0.0369466
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.03693
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0366386
EGFR epidermal growth factor receptor -0.0364864
SMC4 structural maintenance of chromosomes 4 -0.0361138
DENND1A DENN/MADD domain containing 1A -0.0343738
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0341832
TBC1D5 TBC1 domain family, member 5 -0.0334734
MON2 MON2 homolog (S. cerevisiae) -0.0334577
TMEM165 transmembrane protein 165 -0.0333037
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0328979
ATXN1 ataxin 1 -0.0328351
PFKP phosphofructokinase, platelet -0.0327196
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0325532
ZBTB20 zinc finger and BTB domain containing 20 -0.0325193
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0324306
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0322486
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0321249
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0320533
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0320042
WDPCP WD repeat containing planar cell polarity effector -0.031394
MCTP1 multiple C2 domains, transmembrane 1 -0.031158
WASF2 WAS protein family, member 2 -0.0311299
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0310034
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0306635
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0304557
SRBD1 S1 RNA binding domain 1 -0.0302828
GPHN gephyrin -0.0295157
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0292812
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.028976
CAMKMT calmodulin-lysine N-methyltransferase -0.0287933
FAF1 Fas (TNFRSF6) associated factor 1 -0.0281938
SHB Src homology 2 domain containing adaptor protein B -0.0281629
SRPK1 SRSF protein kinase 1 -0.0278652
ANKRD17 ankyrin repeat domain 17 -0.0278366
DIAPH3 diaphanous-related formin 3 -0.0278216
FMN1 formin 1 -0.0273256
ACTN1 actinin, alpha 1 -0.0272483
GATAD2B GATA zinc finger domain containing 2B -0.0269818
ZNF292 zinc finger protein 292 -0.0269012
BABAM2 BRISC and BRCA1 A complex member 2 -0.0267919
ATG7 autophagy related 7 -0.0266218
E2F3 E2F transcription factor 3 -0.0264346
SETD5 SET domain containing 5 -0.0263507
PHIP pleckstrin homology domain interacting protein -0.0261616
NTSR1 neurotensin receptor 1 (high affinity) -0.0260659
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0258275
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0253681
UBE2H ubiquitin-conjugating enzyme E2H -0.0253434
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0252371
TRIO trio Rho guanine nucleotide exchange factor -0.025051
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0249547
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0248046
ZMYND8 zinc finger, MYND-type containing 8 -0.0247835
ATXN2 ataxin 2 -0.0246892
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0246634
FBXO11 F-box protein 11 -0.0244773
NBAS neuroblastoma amplified sequence -0.0243606
PKP4 plakophilin 4 -0.0243167
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.024183
GPATCH2L G patch domain containing 2-like -0.0239712
FCHSD2 FCH and double SH3 domains 2 -0.023764
KMT2D lysine (K)-specific methyltransferase 2D -0.0235918
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0232109
EFNA5 ephrin-A5 -0.0229759
CDK17 cyclin-dependent kinase 17 -0.0229716
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.02282
EXOC4 exocyst complex component 4 -0.022735
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0225743