RMC-6236_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description RMC-6236 perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the RMC-6236_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.26879
FTH1 ferritin, heavy polypeptide 1 0.239105
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.177266
PABPC1 poly(A) binding protein, cytoplasmic 1 0.157187
EEF2 eukaryotic translation elongation factor 2 0.12088
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.11683
POTEF POTE ankyrin domain family, member F 0.0990397
RACK1 receptor for activated C kinase 1 0.0922934
RPS3 ribosomal protein S3 0.0899369
ALCAM activated leukocyte cell adhesion molecule 0.0878154
FTL ferritin, light polypeptide 0.0863691
ZFP36L1 ZFP36 ring finger protein-like 1 0.0805803
PCBP2 poly(rC) binding protein 2 0.0790676
ARRDC3 arrestin domain containing 3 0.0761223
APLP2 amyloid beta (A4) precursor-like protein 2 0.0712091
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0708831
RPS19 ribosomal protein S19 0.0667798
ENO1 enolase 1, (alpha) 0.0652941
BHLHE40 basic helix-loop-helix family, member e40 0.0633056
CTSB cathepsin B 0.061979
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.060664
ZSWIM6 zinc finger, SWIM-type containing 6 0.0602402
VEGFA vascular endothelial growth factor A 0.0594672
RPS12 ribosomal protein S12 0.0574316
RPL12 ribosomal protein L12 0.0569222
RPS8 ribosomal protein S8 0.0561345
MSN moesin 0.0554068
RPS17 ribosomal protein S17 0.0541051
TXNIP thioredoxin interacting protein 0.0536166
BRD2 bromodomain containing 2 0.0536087
DSPP dentin sialophosphoprotein 0.0534944
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.053263
MYH9 myosin, heavy chain 9, non-muscle 0.0517217
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0516518
LOC102724023 ES1 protein homolog, mitochondrial 0.0514922
YBX1 Y box binding protein 1 0.0509691
RPL23 ribosomal protein L23 0.0490247
EIF1 eukaryotic translation initiation factor 1 0.0470703
PRRC2C proline-rich coiled-coil 2C 0.0468515
SGMS2 sphingomyelin synthase 2 0.0456418
KRT7 keratin 7, type II 0.044636
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0443761
LDHA lactate dehydrogenase A 0.0440545
RPS2 ribosomal protein S2 0.0437926
SFTPA2 surfactant protein A2 0.0431256
STAT1 signal transducer and activator of transcription 1, 91kDa 0.042784
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0420951
ADAR adenosine deaminase, RNA-specific 0.0412831
HSPA8 heat shock 70kDa protein 8 0.0409517
RPLP2 ribosomal protein, large, P2 0.0407713
IFI27 interferon, alpha-inducible protein 27 0.0403887
RPL37A ribosomal protein L37a 0.0402123
RPS27 ribosomal protein S27 0.0400499
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0400388
RPS14 ribosomal protein S14 0.0393029
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0392728
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0389065
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0385889
RPL7 ribosomal protein L7 0.0383769
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0379474
SRRM2 serine/arginine repetitive matrix 2 0.0379395
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0374107
RPL8 ribosomal protein L8 0.0372333
NAV2 neuron navigator 2 0.0371355
ATF4 activating transcription factor 4 0.0361458
SON SON DNA binding protein 0.0356148
IFITM1 interferon induced transmembrane protein 1 0.0353927
TPM3 tropomyosin 3 0.0348285
ISG15 ISG15 ubiquitin-like modifier 0.0344166
RPL32 ribosomal protein L32 0.0342809
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0342529
EEF1G eukaryotic translation elongation factor 1 gamma 0.0341428
MX1 MX dynamin-like GTPase 1 0.0341109
FHIT fragile histidine triad 0.0340752
SET SET nuclear proto-oncogene 0.0340361
CENPF centromere protein F, 350/400kDa 0.0340086
MBNL1 muscleblind-like splicing regulator 1 0.0339815
RPS23 ribosomal protein S23 0.0338305
RPLP1 ribosomal protein, large, P1 0.0332634
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.0323748
GPX4 glutathione peroxidase 4 0.0323229
GOLGA4 golgin A4 0.0322554
RPS6 ribosomal protein S6 0.0317939
TMSB10 thymosin beta 10 0.0312559
RPL11 ribosomal protein L11 0.0310757
RPL3 ribosomal protein L3 0.0309654
KTN1 kinectin 1 (kinesin receptor) 0.0309256
CALR calreticulin 0.0308547
DSTN destrin (actin depolymerizing factor) 0.0307929
RPL35A ribosomal protein L35a 0.0304385
FAM13A family with sequence similarity 13, member A 0.0301524
RPL19 ribosomal protein L19 0.0298839
HDGF hepatoma-derived growth factor 0.0297261
TMSB4X thymosin beta 4, X-linked 0.0295217
MAP1B microtubule-associated protein 1B 0.0291438
RPL5 ribosomal protein L5 0.029061
MYOF myoferlin 0.0290605
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.028934
RPL9 ribosomal protein L9 0.0286503
RPL37 ribosomal protein L37 0.0285893

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.134968
ACTG1 actin gamma 1 -0.100755
NPEPPS aminopeptidase puromycin sensitive -0.0968243
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0931641
GRB10 growth factor receptor-bound protein 10 -0.0790024
CD2AP CD2-associated protein -0.0697826
TPT1 tumor protein, translationally-controlled 1 -0.0696914
LMO7 LIM domain 7 -0.0689306
FNDC3B fibronectin type III domain containing 3B -0.0679482
KDM5B lysine (K)-specific demethylase 5B -0.0651412
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0617027
MARCHF6 membrane associated ring-CH-type finger 6 -0.0609385
WSB1 WD repeat and SOCS box containing 1 -0.0571346
BZW1 basic leucine zipper and W2 domains 1 -0.0542503
UBE2H ubiquitin-conjugating enzyme E2H -0.0540228
CCND1 cyclin D1 -0.0533071
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0523309
TSC22D2 TSC22 domain family, member 2 -0.0511519
OGA O-GlcNAcase -0.0501798
ITCH itchy E3 ubiquitin protein ligase -0.0488666
TMEM263 transmembrane protein 263 -0.0480375
GNAS GNAS complex locus -0.0479455
KDM3A lysine (K)-specific demethylase 3A -0.0475289
CAVIN1 caveolae associated protein 1 -0.0474804
RAB1A RAB1A, member RAS oncogene family -0.0460293
OSBPL3 oxysterol binding protein-like 3 -0.0447642
LAMB3 laminin, beta 3 -0.0447511
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0443203
BASP1 brain abundant, membrane attached signal protein 1 -0.0442164
ZFAND3 zinc finger, AN1-type domain 3 -0.0438646
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0437183
SEC31A SEC31 homolog A (S. cerevisiae) -0.0436752
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.042239
TM4SF1 transmembrane 4 L six family member 1 -0.0422203
SLMAP sarcolemma associated protein -0.0413864
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0411172
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0408382
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0407784
FBXO34 F-box protein 34 -0.0386324
F3 coagulation factor III (thromboplastin, tissue factor) -0.0385537
STRN3 striatin, calmodulin binding protein 3 -0.0383948
TPM4 tropomyosin 4 -0.0372063
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0364611
TMEM123 transmembrane protein 123 -0.036108
MSI2 musashi RNA-binding protein 2 -0.0359423
KPNB1 karyopherin (importin) beta 1 -0.0354613
LPP LIM domain containing preferred translocation partner in lipoma -0.0352531
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0350707
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0347282
RCOR1 REST corepressor 1 -0.0343924
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0343887
BLZF1 basic leucine zipper nuclear factor 1 -0.0342694
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.03396
ANXA2 annexin A2 -0.0336908
MYO6 myosin VI -0.0336369
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0336271
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0334592
PTK2 protein tyrosine kinase 2 -0.0323067
LAMC2 laminin, gamma 2 -0.032225
S100A10 S100 calcium binding protein A10 -0.0318216
ASPH aspartate beta-hydroxylase -0.0316923
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0312675
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0311178
FBXO11 F-box protein 11 -0.0310573
CDC73 cell division cycle 73 -0.0310268
NDFIP1 Nedd4 family interacting protein 1 -0.03023
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0298508
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0293998
USP3 ubiquitin specific peptidase 3 -0.0292128
TP53BP2 tumor protein p53 binding protein 2 -0.0292067
FAM3C family with sequence similarity 3, member C -0.0290364
MACF1 microtubule-actin crosslinking factor 1 -0.0286161
SPAG9 sperm associated antigen 9 -0.0285886
KMT2C lysine (K)-specific methyltransferase 2C -0.0282834
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0279881
ERBIN erbb2 interacting protein -0.0278074
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0275512
ZFAND6 zinc finger, AN1-type domain 6 -0.0271111
PLAUR plasminogen activator, urokinase receptor -0.0270721
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0268106
ARHGAP29 Rho GTPase activating protein 29 -0.0266777
MXD1 MAX dimerization protein 1 -0.0265926
ARF1 ADP-ribosylation factor 1 -0.0264675
RAI14 retinoic acid induced 14 -0.0263921
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0262644
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0262115
PRRC1 proline-rich coiled-coil 1 -0.0259564
CDCP1 CUB domain containing protein 1 -0.0259529
NDRG1 N-myc downstream regulated 1 -0.0255911
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.025441
RTN4 reticulon 4 -0.0253399
AFF4 AF4/FMR2 family, member 4 -0.0252429
F11R F11 receptor -0.0251797
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0250243
BIRC6 baculoviral IAP repeat containing 6 -0.0249477
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0248843
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0247932
PGK1 phosphoglycerate kinase 1 -0.0246897
WASF2 WAS protein family, member 2 -0.0245444
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0245198