RMC-6236_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description RMC-6236 perturbation in NCI-H460 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the RMC-6236_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.153465
VIM vimentin 0.115326
EEF2 eukaryotic translation elongation factor 2 0.112025
FTH1 ferritin, heavy polypeptide 1 0.103697
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0757205
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0736307
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0691635
IGFBP3 insulin-like growth factor binding protein 3 0.0621428
CANX calnexin 0.0613011
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0583624
RPS8 ribosomal protein S8 0.0573345
PCBP2 poly(rC) binding protein 2 0.056613
FN1 fibronectin 1 0.0541107
ESYT2 extended synaptotagmin-like protein 2 0.052967
RPL26 ribosomal protein L26 0.0527604
XYLT1 xylosyltransferase I 0.0523284
RPS12 ribosomal protein S12 0.0505764
RACK1 receptor for activated C kinase 1 0.0499874
BASP1 brain abundant, membrane attached signal protein 1 0.0493701
ENO1 enolase 1, (alpha) 0.0490165
SMOC1 SPARC related modular calcium binding 1 0.0469246
RPS3 ribosomal protein S3 0.0463679
RPS6 ribosomal protein S6 0.045964
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0454854
LOC102724023 ES1 protein homolog, mitochondrial 0.0445934
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0444491
LSAMP limbic system-associated membrane protein 0.0442186
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0427331
LGALS3 lectin, galactoside-binding, soluble, 3 0.0423349
MAP7 microtubule-associated protein 7 0.0419071
SFTPA2 surfactant protein A2 0.0412457
RPL37A ribosomal protein L37a 0.0411263
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0408114
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0406937
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0401354
STC2 stanniocalcin 2 0.0396901
PDE10A phosphodiesterase 10A 0.0395863
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0389557
RPS2 ribosomal protein S2 0.038882
FMNL2 formin-like 2 0.0386279
LDHA lactate dehydrogenase A 0.0385318
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0384321
DNER delta/notch-like EGF repeat containing 0.0383643
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 0.0379896
SMAD2 SMAD family member 2 0.0373836
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0358125
B2M beta-2-microglobulin 0.0357926
RPL31 ribosomal protein L31 0.0353249
NDRG1 N-myc downstream regulated 1 0.0349439
MYOF myoferlin 0.0346067
RPL12 ribosomal protein L12 0.0341476
WARS1 tryptophanyl-tRNA synthetase 1 0.0338567
AKAP12 A kinase (PRKA) anchor protein 12 0.0335576
CDH13 cadherin 13 0.0333606
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0331993
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0329956
SQSTM1 sequestosome 1 0.0328603
EIF1 eukaryotic translation initiation factor 1 0.032224
NAP1L1 nucleosome assembly protein 1-like 1 0.0321995
IRS2 insulin receptor substrate 2 0.032122
CHL1 cell adhesion molecule L1-like 0.031994
RPS17 ribosomal protein S17 0.0313354
AUTS2 autism susceptibility candidate 2 0.031216
SRRM2 serine/arginine repetitive matrix 2 0.0299335
DGKD diacylglycerol kinase, delta 130kDa 0.0299146
OLFML2A olfactomedin-like 2A 0.029885
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0285313
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.028507
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0278636
NRXN3 neurexin 3 0.0276497
TPM3 tropomyosin 3 0.0276402
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0276339
RPS27 ribosomal protein S27 0.0273903
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0273688
CTIF CBP80/20-dependent translation initiation factor 0.0270353
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0266959
RPL37 ribosomal protein L37 0.0265176
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.026339
DDIT4 DNA-damage-inducible transcript 4 0.0262039
INHBA inhibin, beta A 0.026178
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0256319
PGK1 phosphoglycerate kinase 1 0.0256027
RPS4X ribosomal protein S4, X-linked 0.0255718
RAD51B RAD51 paralog B 0.0252856
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0252638
RPS27A ribosomal protein S27a 0.0249075
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0248588
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0245261
CTBP2 C-terminal binding protein 2 0.0244797
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0244766
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0240646
CLU clusterin 0.0238658
CTSL cathepsin L 0.0238197
RPL3 ribosomal protein L3 0.0236528
RPL9 ribosomal protein L9 0.0235059
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0231798
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0230147
FNIP1 folliculin interacting protein 1 0.0226711
FAM107B family with sequence similarity 107, member B 0.022655
CD109 CD109 molecule 0.022614

decreased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 -0.164295
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.15747
GDA guanine deaminase -0.14937
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.12844
SMYD3 SET and MYND domain containing 3 -0.111802
TXNRD1 thioredoxin reductase 1 -0.103284
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0918086
NRCAM neuronal cell adhesion molecule -0.0868134
ASPH aspartate beta-hydroxylase -0.0855219
TFPI2 tissue factor pathway inhibitor 2 -0.0815773
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0778489
NEK7 NIMA-related kinase 7 -0.0770197
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0741021
NPAS2 neuronal PAS domain protein 2 -0.0652051
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0597348
TRIO trio Rho guanine nucleotide exchange factor -0.0584346
TM4SF1 transmembrane 4 L six family member 1 -0.0583509
RTN4 reticulon 4 -0.0548667
ENAH enabled homolog (Drosophila) -0.0546632
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0539359
VCL vinculin -0.0533781
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0522393
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0521221
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.05018
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0483221
RTN1 reticulon 1 -0.046456
GRAMD1B GRAM domain containing 1B -0.0450463
TNPO1 transportin 1 -0.0427255
CTSC cathepsin C -0.0424905
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0424737
NAMPT nicotinamide phosphoribosyltransferase -0.041966
PCBP3 poly(rC) binding protein 3 -0.0404506
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0394534
TMSB10 thymosin beta 10 -0.0376055
RBM39 RNA binding motif protein 39 -0.0371783
BCAR3 breast cancer anti-estrogen resistance 3 -0.0353384
AKR1C1 aldo-keto reductase family 1, member C1 -0.0352831
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0348479
COL4A5 collagen, type IV, alpha 5 -0.0343478
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0339119
NCOA7 nuclear receptor coactivator 7 -0.0332495
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0327702
OSMR oncostatin M receptor -0.0323663
PTGR1 prostaglandin reductase 1 -0.0318279
PSD3 pleckstrin and Sec7 domain containing 3 -0.0314506
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0314355
KYNU kynureninase -0.0300992
PHF20 PHD finger protein 20 -0.0291225
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0286988
ARHGAP29 Rho GTPase activating protein 29 -0.0286767
ITPRID2 ITPR interacting domain containing 2 -0.0285914
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0284982
SRGN serglycin -0.0283641
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0283542
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0282903
ANKRD17 ankyrin repeat domain 17 -0.0280997
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0277311
BMERB1 bMERB domain containing 1 -0.0277193
OGA O-GlcNAcase -0.0276667
KIF21A kinesin family member 21A -0.0276172
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0275788
DOCK4 dedicator of cytokinesis 4 -0.0275785
PBX1 pre-B-cell leukemia homeobox 1 -0.0272578
DST dystonin -0.0271402
CARD16 caspase recruitment domain family, member 16 -0.0269398
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0268621
ATAD1 ATPase family, AAA domain containing 1 -0.026833
WWTR1 WW domain containing transcription regulator 1 -0.0264753
NF1 neurofibromin 1 -0.0263965
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0261977
GNAS GNAS complex locus -0.026028
PRRC2B proline-rich coiled-coil 2B -0.0256203
CENPF centromere protein F, 350/400kDa -0.0254048
PALLD palladin, cytoskeletal associated protein -0.025307
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0251067
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0249114
UBE2H ubiquitin-conjugating enzyme E2H -0.0248433
RBMS2 RNA binding motif, single stranded interacting protein 2 -0.0246069
DIAPH2 diaphanous-related formin 2 -0.0245584
AOPEP aminopeptidase O (putative) -0.0245067
TUSC3 tumor suppressor candidate 3 -0.024451
AGFG1 ArfGAP with FG repeats 1 -0.0243345
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0243312
SLC38A2 solute carrier family 38, member 2 -0.024181
CFLAR CASP8 and FADD-like apoptosis regulator -0.0239688
CLIP1 CAP-GLY domain containing linker protein 1 -0.0237135
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0236285
DOCK5 dedicator of cytokinesis 5 -0.0236219
CDK17 cyclin-dependent kinase 17 -0.0234765
DPYD dihydropyrimidine dehydrogenase -0.0233837
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0229314
ZNF804A zinc finger protein 804A -0.0228182
MKI67 marker of proliferation Ki-67 -0.0227404
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0224279
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0219925
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0217567
THOC2 THO complex 2 -0.0217041
ACACA acetyl-CoA carboxylase alpha -0.0216517
PUM2 pumilio RNA-binding family member 2 -0.0216465
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0215998