| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the RMC-6236_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.237127 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.120574 |
| ZNF638 | zinc finger protein 638 | 0.106857 |
| GPC6 | glypican 6 | 0.102053 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.100281 |
| FN1 | fibronectin 1 | 0.097718 |
| COL5A2 | collagen, type V, alpha 2 | 0.0969849 |
| DTNA | dystrobrevin, alpha | 0.0964675 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0950946 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0946182 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0862373 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0805388 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0785885 |
| VGF | VGF nerve growth factor inducible | 0.0701036 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0698129 |
| NDRG1 | N-myc downstream regulated 1 | 0.069525 |
| EFNA5 | ephrin-A5 | 0.0663195 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.064993 |
| FLNB | filamin B, beta | 0.0635037 |
| RNF213 | ring finger protein 213 | 0.0633507 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0628827 |
| VEGFA | vascular endothelial growth factor A | 0.0615596 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0613366 |
| MYOF | myoferlin | 0.0612766 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0611086 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0590521 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0583877 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.058112 |
| SMAD3 | SMAD family member 3 | 0.057236 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0538795 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0526965 |
| MED13L | mediator complex subunit 13-like | 0.0526056 |
| MYO6 | myosin VI | 0.0515455 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.05019 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0500336 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0499562 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0499387 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0481886 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0469484 |
| EGFR | epidermal growth factor receptor | 0.0465862 |
| NLGN1 | neuroligin 1 | 0.0457458 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.045738 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0454435 |
| FMNL2 | formin-like 2 | 0.0414731 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0390635 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0383684 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0372298 |
| CD44 | CD44 molecule (Indian blood group) | 0.0370281 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.036767 |
| B2M | beta-2-microglobulin | 0.0367363 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0365339 |
| OGA | O-GlcNAcase | 0.035386 |
| SMYD3 | SET and MYND domain containing 3 | 0.0353691 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0347078 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0332514 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | 0.032718 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.032586 |
| FAT1 | FAT atypical cadherin 1 | 0.0323728 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0323576 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0316577 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0313962 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0312008 |
| PTK2 | protein tyrosine kinase 2 | 0.0311044 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0308454 |
| RPS27A | ribosomal protein S27a | 0.0306598 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0300349 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0299594 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0298517 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0274442 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0272796 |
| RBM39 | RNA binding motif protein 39 | 0.0272143 |
| RTN4 | reticulon 4 | 0.0266299 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0264846 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0261515 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0255109 |
| ATXN1 | ataxin 1 | 0.0254138 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0246255 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0242227 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0238482 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0237643 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 0.0234146 |
| PRELID2 | PRELI domain containing 2 | 0.0230303 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0228332 |
| RSF1 | remodeling and spacing factor 1 | 0.02273 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0223055 |
| TMEM45B | transmembrane protein 45B | 0.022261 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0222042 |
| DST | dystonin | 0.0216086 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.021475 |
| LSAMP | limbic system-associated membrane protein | 0.0212914 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0211968 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0202899 |
| SLTM | SAFB-like, transcription modulator | 0.020235 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0188093 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0181627 |
| EZR | ezrin | 0.0171048 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0170591 |
| IGF2 | insulin-like growth factor 2 | 0.0165988 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0156188 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0133259 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.311502 |
| PTMA | prothymosin, alpha | -0.206107 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.14547 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.137823 |
| RPS6 | ribosomal protein S6 | -0.111308 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.109609 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0890523 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0873795 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0812142 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0810225 |
| PKM | pyruvate kinase, muscle | -0.0795543 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0783726 |
| MCL1 | myeloid cell leukemia 1 | -0.0747612 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0743557 |
| H3-3B | H3.3 histone B | -0.070627 |
| LAMA4 | laminin, alpha 4 | -0.068656 |
| POTEF | POTE ankyrin domain family, member F | -0.0676194 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0630782 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0627952 |
| PDE10A | phosphodiesterase 10A | -0.0622796 |
| RPS8 | ribosomal protein S8 | -0.0604543 |
| MT2A | metallothionein 2A | -0.0594371 |
| PGK1 | phosphoglycerate kinase 1 | -0.0579217 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0575896 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0562367 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0554011 |
| RPS3 | ribosomal protein S3 | -0.0544675 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0534337 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0531981 |
| VIM | vimentin | -0.0509691 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0491737 |
| RPL35A | ribosomal protein L35a | -0.0484293 |
| JMJD1C | jumonji domain containing 1C | -0.0471077 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0465482 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0435207 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0418901 |
| RPL11 | ribosomal protein L11 | -0.0416201 |
| RPL23 | ribosomal protein L23 | -0.0400989 |
| SBF2 | SET binding factor 2 | -0.0394592 |
| RPS12 | ribosomal protein S12 | -0.0384925 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0384295 |
| UBC | ubiquitin C | -0.0379943 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.0369965 |
| FTL | ferritin, light polypeptide | -0.0365673 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0364119 |
| ZNF292 | zinc finger protein 292 | -0.0362618 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0353196 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0351443 |
| ACTG1 | actin gamma 1 | -0.0336907 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0321766 |
| VCL | vinculin | -0.031809 |
| SRPK2 | SRSF protein kinase 2 | -0.0307482 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0306606 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0285037 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0265655 |
| RLF | rearranged L-myc fusion | -0.0265441 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0260762 |
| RPL19 | ribosomal protein L19 | -0.0246621 |
| GOLGB1 | golgin B1 | -0.0243231 |
| TMSB10 | thymosin beta 10 | -0.0240141 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0240082 |
| SMC5 | structural maintenance of chromosomes 5 | -0.023699 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0234396 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0232504 |
| CCNI | cyclin I | -0.0226455 |
| COG5 | component of oligomeric golgi complex 5 | -0.020977 |
| TXNRD1 | thioredoxin reductase 1 | -0.0204091 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0200557 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0189088 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0175329 |
| SPAG9 | sperm associated antigen 9 | -0.0166041 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0163274 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0162623 |
| LDHA | lactate dehydrogenase A | -0.0154929 |
| NUP58 | nucleoporin 58 | -0.0144199 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0138029 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0132188 |
| NAV2 | neuron navigator 2 | -0.0130026 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0122014 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0120549 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0107515 |
| CANX | calnexin | -0.0103645 |
| SPIDR | scaffolding protein involved in DNA repair | -0.00976285 |
| USP34 | ubiquitin specific peptidase 34 | -0.00936098 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.00822421 |
| PARD3 | par-3 family cell polarity regulator | -0.00770451 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.00737795 |
| RPL37A | ribosomal protein L37a | -0.00723228 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0068621 |
| RAB7A | RAB7A, member RAS oncogene family | -0.00664396 |
| GSK3B | glycogen synthase kinase 3 beta | -0.00550046 |
| VMP1 | vacuole membrane protein 1 | -0.00536588 |
| MYO1E | myosin IE | -0.00525285 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.00509801 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.00295407 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.00274185 |
| MAP4 | microtubule-associated protein 4 | -0.00252222 |
| ANXA2 | annexin A2 | -0.002505 |
| PRRC2C | proline-rich coiled-coil 2C | -0.00227052 |
| SQSTM1 | sequestosome 1 | -0.00139554 |
