| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the RMC-6236_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | 0.149497 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0663585 |
| HDAC9 | histone deacetylase 9 | 0.0539788 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0484072 |
| COL5A2 | collagen, type V, alpha 2 | 0.0464832 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0456803 |
| CADM2 | cell adhesion molecule 2 | 0.0421506 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0419021 |
| PHF3 | PHD finger protein 3 | 0.0391944 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0390564 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0372053 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0369928 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0364699 |
| FOXP2 | forkhead box P2 | 0.0350297 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0335754 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0335746 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0326028 |
| MEIS2 | Meis homeobox 2 | 0.0325263 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.0317093 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0311123 |
| RBM39 | RNA binding motif protein 39 | 0.0309665 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.030837 |
| MED13L | mediator complex subunit 13-like | 0.0304158 |
| BRD2 | bromodomain containing 2 | 0.0285655 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0282294 |
| PCBP2 | poly(rC) binding protein 2 | 0.0281675 |
| OGA | O-GlcNAcase | 0.0276791 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0272136 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0267868 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.0264414 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0263978 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0260302 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0259611 |
| MEF2A | myocyte enhancer factor 2A | 0.0259018 |
| JMJD1C | jumonji domain containing 1C | 0.0258286 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0258143 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0258073 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0256522 |
| APP | amyloid beta (A4) precursor protein | 0.0247984 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0246197 |
| CSRNP3 | cysteine-serine-rich nuclear protein 3 | 0.024572 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0245232 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0244482 |
| RPS2 | ribosomal protein S2 | 0.0244161 |
| SSR1 | signal sequence receptor, alpha | 0.0237088 |
| UGGT1 | UDP-glucose glycoprotein glucosyltransferase 1 | 0.0230614 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0230301 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0227614 |
| ARRDC3 | arrestin domain containing 3 | 0.0227546 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | 0.0226945 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0223749 |
| ITSN2 | intersectin 2 | 0.0222736 |
| KIF5B | kinesin family member 5B | 0.0221405 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0220236 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0217855 |
| MEMO1 | mediator of cell motility 1 | 0.0217584 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0215123 |
| FMNL2 | formin-like 2 | 0.021462 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0213034 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.020956 |
| UTRN | utrophin | 0.0207085 |
| SON | SON DNA binding protein | 0.020704 |
| MYO6 | myosin VI | 0.0204884 |
| FLNA | filamin A, alpha | 0.0203022 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0201583 |
| PROS1 | protein S (alpha) | 0.0197623 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.019736 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0196617 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.019383 |
| CDC73 | cell division cycle 73 | 0.0193488 |
| ZNF608 | zinc finger protein 608 | 0.0192174 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0191703 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0191161 |
| SFTPA2 | surfactant protein A2 | 0.0190584 |
| CTSB | cathepsin B | 0.0190252 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0190152 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0189702 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0189078 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0188952 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0188333 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0187438 |
| ICE1 | interactor of little elongation complex ELL subunit 1 | 0.018713 |
| NCKAP1 | NCK-associated protein 1 | 0.0185853 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0184693 |
| H1-4 | H1.4 linker histone, cluster member | 0.0184132 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0183761 |
| CRY1 | cryptochrome circadian clock 1 | 0.0182387 |
| SDF4 | stromal cell derived factor 4 | 0.0181586 |
| RASAL2 | RAS protein activator like 2 | 0.0181293 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0177846 |
| VWA8 | von Willebrand factor A domain containing 8 | 0.0171889 |
| STK38 | serine/threonine kinase 38 | 0.0171621 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0171621 |
| YBX1 | Y box binding protein 1 | 0.0171494 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0168329 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.0167669 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0167356 |
| MYO10 | myosin X | 0.0166881 |
| CLIC4 | chloride intracellular channel 4 | 0.0166853 |
| FILIP1 | filamin A interacting protein 1 | 0.0166758 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.223599 |
| VIM | vimentin | -0.146178 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.133545 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.108205 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.104122 |
| TMSB10 | thymosin beta 10 | -0.0974423 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0957588 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0918494 |
| NRG1 | neuregulin 1 | -0.0826315 |
| ACTG1 | actin gamma 1 | -0.0757587 |
| ITGAV | integrin, alpha V | -0.0757277 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0722858 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0669259 |
| RPS6 | ribosomal protein S6 | -0.0637779 |
| GNAS | GNAS complex locus | -0.0633052 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0622649 |
| PTMA | prothymosin, alpha | -0.06057 |
| COL1A2 | collagen, type I, alpha 2 | -0.0600851 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0596096 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0582815 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0577417 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.057583 |
| PFN1 | profilin 1 | -0.0568728 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0526871 |
| PGK1 | phosphoglycerate kinase 1 | -0.0517739 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0501602 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0500203 |
| TENM2 | teneurin transmembrane protein 2 | -0.0490411 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0488715 |
| PHIP | pleckstrin homology domain interacting protein | -0.0484374 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0468061 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0464678 |
| SYT1 | synaptotagmin I | -0.0458324 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0456296 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0452568 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0441519 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0423196 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0420394 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.041869 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | -0.041299 |
| CCN2 | cellular communication network factor 2 | -0.0409193 |
| TENM3 | teneurin transmembrane protein 3 | -0.040912 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0407402 |
| SLC38A2 | solute carrier family 38, member 2 | -0.040419 |
| RPS16 | ribosomal protein S16 | -0.0388623 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.0383114 |
| RPL35A | ribosomal protein L35a | -0.0382675 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0382623 |
| VMP1 | vacuole membrane protein 1 | -0.0374395 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0369348 |
| SHROOM3 | shroom family member 3 | -0.0366257 |
| TUBA1B | tubulin, alpha 1b | -0.0361916 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0360506 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.0359778 |
| CENPF | centromere protein F, 350/400kDa | -0.0359698 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0356866 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0352571 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0350057 |
| EMP1 | epithelial membrane protein 1 | -0.0349273 |
| TRERF1 | transcriptional regulating factor 1 | -0.0342627 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0338961 |
| HMGB1 | high mobility group box 1 | -0.033241 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0332395 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0330392 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0330262 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0328738 |
| LRRC4C | leucine rich repeat containing 4C | -0.0325676 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0325345 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0323261 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0322732 |
| RPL19 | ribosomal protein L19 | -0.0322433 |
| RPL34 | ribosomal protein L34 | -0.0319669 |
| PCDH9 | protocadherin 9 | -0.0316608 |
| DMD | dystrophin | -0.0312683 |
| RAI1 | retinoic acid induced 1 | -0.0312386 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0312092 |
| S100A9 | S100 calcium binding protein A9 | -0.0311433 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0308907 |
| POTEF | POTE ankyrin domain family, member F | -0.0306273 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0305607 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0301867 |
| RTN4 | reticulon 4 | -0.0299648 |
| RPS24 | ribosomal protein S24 | -0.0298466 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0298363 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0298175 |
| PRELID2 | PRELI domain containing 2 | -0.0297891 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0296381 |
| WASF2 | WAS protein family, member 2 | -0.0293238 |
| RBM20 | RNA binding motif protein 20 | -0.0288478 |
| RPS19 | ribosomal protein S19 | -0.0282785 |
| BPTF | bromodomain PHD finger transcription factor | -0.0279671 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.0279394 |
| RPLP0 | ribosomal protein, large, P0 | -0.0277572 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.027358 |
| FBXO11 | F-box protein 11 | -0.0273244 |
| HMGA1 | high mobility group AT-hook 1 | -0.0271946 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0269506 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0268362 |
| GLI3 | GLI family zinc finger 3 | -0.0264863 |
| RPS21 | ribosomal protein S21 | -0.0263541 |
