| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the RMC-6236_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.163162 |
| SGMS2 | sphingomyelin synthase 2 | 0.0996891 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0980252 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0897294 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0846442 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0792372 |
| RPL7 | ribosomal protein L7 | 0.0725898 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0723055 |
| RPL12 | ribosomal protein L12 | 0.0690417 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0659592 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0652765 |
| RPS2 | ribosomal protein S2 | 0.0645846 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0597111 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0589682 |
| ACTG1 | actin gamma 1 | 0.0554542 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0542611 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0532521 |
| JMJD1C | jumonji domain containing 1C | 0.0520049 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0510822 |
| RCOR1 | REST corepressor 1 | 0.0509848 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0499107 |
| RPS8 | ribosomal protein S8 | 0.0492405 |
| JUN | jun proto-oncogene | 0.0488831 |
| RACK1 | receptor for activated C kinase 1 | 0.0484822 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0465486 |
| RPS6 | ribosomal protein S6 | 0.0463271 |
| CORO1C | coronin, actin binding protein, 1C | 0.0455929 |
| MCL1 | myeloid cell leukemia 1 | 0.0447958 |
| RPS12 | ribosomal protein S12 | 0.044417 |
| RPS3 | ribosomal protein S3 | 0.0441234 |
| RPL3 | ribosomal protein L3 | 0.0439734 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.04298 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0423854 |
| RPL7A | ribosomal protein L7a | 0.0417893 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.04161 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0413309 |
| STC1 | stanniocalcin 1 | 0.0410474 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0397515 |
| UPP1 | uridine phosphorylase 1 | 0.0393497 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0390201 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.0379154 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0376744 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.037047 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0361548 |
| CD68 | CD68 molecule | 0.0356789 |
| LAMB3 | laminin, beta 3 | 0.0354706 |
| SET | SET nuclear proto-oncogene | 0.0353591 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0350123 |
| RASA2 | RAS p21 protein activator 2 | 0.034007 |
| FRMD6 | FERM domain containing 6 | 0.033988 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0338258 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0333931 |
| EFNB2 | ephrin-B2 | 0.0332972 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.033002 |
| RPS4X | ribosomal protein S4, X-linked | 0.0328424 |
| RPL23 | ribosomal protein L23 | 0.032013 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0316702 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0312081 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0308824 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0307573 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0302805 |
| B2M | beta-2-microglobulin | 0.0298334 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0297533 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0295425 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0292836 |
| SON | SON DNA binding protein | 0.0292251 |
| FLNA | filamin A, alpha | 0.0290945 |
| RPL37A | ribosomal protein L37a | 0.0288066 |
| RPS19 | ribosomal protein S19 | 0.028491 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0282369 |
| RPS27A | ribosomal protein S27a | 0.0277866 |
| RPL35 | ribosomal protein L35 | 0.0277319 |
| ATF4 | activating transcription factor 4 | 0.0275677 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0274407 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0273578 |
| ATP13A3 | ATPase type 13A3 | 0.0273345 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0273141 |
| SFTPA2 | surfactant protein A2 | 0.026817 |
| TXNRD1 | thioredoxin reductase 1 | 0.0267537 |
| YBX1 | Y box binding protein 1 | 0.0261695 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0257627 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0254867 |
| RPS17 | ribosomal protein S17 | 0.0251447 |
| RUNX1 | runt-related transcription factor 1 | 0.0249973 |
| RPLP1 | ribosomal protein, large, P1 | 0.0249953 |
| TLN1 | talin 1 | 0.0247608 |
| ADTRP | androgen-dependent TFPI-regulating protein | 0.0246022 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0243038 |
| CD44 | CD44 molecule (Indian blood group) | 0.0240305 |
| FHL2 | four and a half LIM domains 2 | 0.0235702 |
| KLF10 | Kruppel-like factor 10 | 0.023516 |
| BRD2 | bromodomain containing 2 | 0.0234945 |
| KIF5B | kinesin family member 5B | 0.0233235 |
| TOP1 | topoisomerase (DNA) I | 0.0232514 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0232183 |
| MTDH | metadherin | 0.0229045 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0228744 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0228331 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0226281 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0225954 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DLC1 | DLC1 Rho GTPase activating protein | -0.126931 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.109806 |
| ZNF438 | zinc finger protein 438 | -0.108549 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.100877 |
| PTK2 | protein tyrosine kinase 2 | -0.0763325 |
| BNC2 | basonuclin 2 | -0.0751701 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0734446 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0733581 |
| TTR | transthyretin | -0.0727787 |
| NABP1 | nucleic acid binding protein 1 | -0.0727158 |
| CALD1 | caldesmon 1 | -0.0703704 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0697755 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0690822 |
| FRMD4A | FERM domain containing 4A | -0.0665714 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0596603 |
| PCNX4 | pecanex 4 | -0.0591574 |
| MTAP | methylthioadenosine phosphorylase | -0.0570441 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0527528 |
| RAD51B | RAD51 paralog B | -0.052301 |
| FHIT | fragile histidine triad | -0.0510303 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0510258 |
| DENND1A | DENN/MADD domain containing 1A | -0.0509918 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0500099 |
| DIAPH3 | diaphanous-related formin 3 | -0.0488515 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0482692 |
| NAV3 | neuron navigator 3 | -0.0447846 |
| NF1 | neurofibromin 1 | -0.0436195 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0435409 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0421862 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0417905 |
| FLNB | filamin B, beta | -0.0407309 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0404295 |
| NAV2 | neuron navigator 2 | -0.039513 |
| TCF12 | transcription factor 12 | -0.0385231 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0378711 |
| SRPK2 | SRSF protein kinase 2 | -0.0363237 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0361723 |
| SNX14 | sorting nexin 14 | -0.0344811 |
| ANK2 | ankyrin 2, neuronal | -0.034069 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0331339 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0327724 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0327574 |
| ATXN2 | ataxin 2 | -0.032539 |
| ZNF292 | zinc finger protein 292 | -0.0324687 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.032376 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0322851 |
| RAB3IP | RAB3A interacting protein | -0.0320136 |
| EXOC4 | exocyst complex component 4 | -0.0311629 |
| MROH1 | maestro heat-like repeat family member 1 | -0.030882 |
| RIGI | RNA sensor RIG-I | -0.0308807 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | -0.030782 |
| RBM25 | RNA binding motif protein 25 | -0.030616 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0302568 |
| SBF2 | SET binding factor 2 | -0.0300256 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0295207 |
| DGKI | diacylglycerol kinase, iota | -0.0293238 |
| CUX1 | cut-like homeobox 1 | -0.028514 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0276931 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0274616 |
| PARD3 | par-3 family cell polarity regulator | -0.0273658 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0272682 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | -0.0269988 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0269539 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0267449 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.026489 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0263834 |
| CDK6 | cyclin-dependent kinase 6 | -0.026348 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.026195 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0261862 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0261358 |
| MYRFL | myelin regulatory factor-like | -0.0259102 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0255597 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0254703 |
| BBX | bobby sox homolog (Drosophila) | -0.0254364 |
| FUS | FUS RNA binding protein | -0.0251573 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0251119 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0248265 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0238047 |
| YEATS2 | YEATS domain containing 2 | -0.0235446 |
| SRPK1 | SRSF protein kinase 1 | -0.0235387 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0232493 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.0229039 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.0226823 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0226667 |
| PRKCE | protein kinase C, epsilon | -0.0223819 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.022254 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0221764 |
| MYSM1 | Myb-like, SWIRM and MPN domains 1 | -0.0219631 |
| TPD52 | tumor protein D52 | -0.021807 |
| CD2AP | CD2-associated protein | -0.0217411 |
| RBM39 | RNA binding motif protein 39 | -0.0216525 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0214612 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0213603 |
| THOC2 | THO complex 2 | -0.021296 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0212321 |
| MSH4 | mutS homolog 4 | -0.0211199 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0210797 |
| GNAS | GNAS complex locus | -0.0210786 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0208735 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.020809 |
