| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the RMC-6236_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.1444 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.108078 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.101757 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0753758 |
| CPE | carboxypeptidase E | 0.0655708 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0648597 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0606711 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0559949 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0549169 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0546665 |
| NBEA | neurobeachin | 0.0493682 |
| TOX | thymocyte selection-associated high mobility group box | 0.048282 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0468773 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0465824 |
| INHBA | inhibin, beta A | 0.0463851 |
| IRS2 | insulin receptor substrate 2 | 0.0439339 |
| CHGB | chromogranin B | 0.042258 |
| WWOX | WW domain containing oxidoreductase | 0.0391995 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0380844 |
| PCBP2 | poly(rC) binding protein 2 | 0.0364507 |
| FGF9 | fibroblast growth factor 9 | 0.0363165 |
| RPS3 | ribosomal protein S3 | 0.0340432 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.033168 |
| SIK2 | salt-inducible kinase 2 | 0.0328149 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0323826 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0323757 |
| RUNX1 | runt-related transcription factor 1 | 0.0322057 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0318952 |
| MYLIP | myosin regulatory light chain interacting protein | 0.0316817 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0316381 |
| TPM3 | tropomyosin 3 | 0.030899 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.030796 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0305538 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0303549 |
| RPS2 | ribosomal protein S2 | 0.0300759 |
| FAT1 | FAT atypical cadherin 1 | 0.0283318 |
| RNASE12 | ribonuclease, RNase A family, 12 (non-active) | 0.0283089 |
| RPL37A | ribosomal protein L37a | 0.0280564 |
| SVIL | supervillin | 0.0276015 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0275492 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0275409 |
| THSD7A | thrombospondin, type I, domain containing 7A | 0.0271857 |
| SCG3 | secretogranin III | 0.0257179 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0256478 |
| RALYL | RALY RNA binding protein-like | 0.0250401 |
| ATF4 | activating transcription factor 4 | 0.0250377 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0243437 |
| RPL26 | ribosomal protein L26 | 0.024134 |
| ELMO1 | engulfment and cell motility 1 | 0.023856 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.023604 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0235294 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0232206 |
| RPL3 | ribosomal protein L3 | 0.0229027 |
| ZFHX3 | zinc finger homeobox 3 | 0.0228668 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0227469 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0226861 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | 0.0226424 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0225263 |
| RNF144A | ring finger protein 144A | 0.0225041 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0224754 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0219855 |
| RPS12 | ribosomal protein S12 | 0.02151 |
| B2M | beta-2-microglobulin | 0.0211819 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0211456 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0210515 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0208535 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.020684 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0205216 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0200285 |
| TSR1 | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.0200156 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0199074 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0198849 |
| STC1 | stanniocalcin 1 | 0.0197013 |
| SSR1 | signal sequence receptor, alpha | 0.0196134 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | 0.0194332 |
| PARM1 | prostate androgen-regulated mucin-like protein 1 | 0.0193625 |
| EGFR | epidermal growth factor receptor | 0.0192116 |
| RACK1 | receptor for activated C kinase 1 | 0.0192107 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0191861 |
| BSDC1 | BSD domain containing 1 | 0.0191458 |
| KAT6A | K(lysine) acetyltransferase 6A | 0.0190536 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.0190226 |
| MX2 | MX dynamin-like GTPase 2 | 0.0189975 |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.0189154 |
| ADAR | adenosine deaminase, RNA-specific | 0.0188279 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0187969 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0187672 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0186357 |
| CRY1 | cryptochrome circadian clock 1 | 0.0186323 |
| TRIM44 | tripartite motif containing 44 | 0.0186131 |
| GOLGA4 | golgin A4 | 0.0186023 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0185029 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0182746 |
| PCM1 | pericentriolar material 1 | 0.0182107 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0181306 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0181119 |
| MYO1B | myosin IB | 0.0180265 |
| BRD2 | bromodomain containing 2 | 0.0179252 |
| TSPYL2 | TSPY-like 2 | 0.0179193 |
| SETX | senataxin | 0.0178258 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TENM1 | teneurin transmembrane protein 1 | -0.17395 |
| CALCA | calcitonin-related polypeptide alpha | -0.132617 |
| PEG10 | paternally expressed 10 | -0.125425 |
| GPC6 | glypican 6 | -0.113926 |
| EGR1 | early growth response 1 | -0.103768 |
| NRG1 | neuregulin 1 | -0.10306 |
| ESRRG | estrogen-related receptor gamma | -0.101661 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0972016 |
| PTMA | prothymosin, alpha | -0.0955755 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -0.0939056 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.086885 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0867179 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0809992 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0769064 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.075989 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.073726 |
| MCL1 | myeloid cell leukemia 1 | -0.0679897 |
| SMYD3 | SET and MYND domain containing 3 | -0.0647679 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0605959 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | -0.0590045 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0565795 |
| PTCHD4 | patched domain containing 4 | -0.0563944 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.056152 |
| GPC5 | glypican 5 | -0.0515163 |
| RORA | RAR-related orphan receptor A | -0.0512907 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0489498 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0486744 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.0475124 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.04707 |
| TPD52 | tumor protein D52 | -0.0444025 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0437138 |
| FGF14 | fibroblast growth factor 14 | -0.0436371 |
| CENPF | centromere protein F, 350/400kDa | -0.0430093 |
| ACTG1 | actin gamma 1 | -0.0428992 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0420957 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0414041 |
| DTNA | dystrobrevin, alpha | -0.0402903 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0386105 |
| RIT2 | Ras-like without CAAX 2 | -0.0385886 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.038486 |
| MKI67 | marker of proliferation Ki-67 | -0.038155 |
| ECT2 | epithelial cell transforming 2 | -0.0369469 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0366714 |
| GNAS | GNAS complex locus | -0.0366462 |
| NAV2 | neuron navigator 2 | -0.0362313 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0357855 |
| WDR45B | WD repeat domain 45B | -0.0357542 |
| ZBTB7C | zinc finger and BTB domain containing 7C | -0.0354723 |
| TUBB | tubulin, beta class I | -0.0350771 |
| NDRG1 | N-myc downstream regulated 1 | -0.034595 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0342221 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0338517 |
| FUS | FUS RNA binding protein | -0.033749 |
| FBXO34 | F-box protein 34 | -0.0337461 |
| SYT1 | synaptotagmin I | -0.0337123 |
| EFNA5 | ephrin-A5 | -0.0333698 |
| SLC35F4 | solute carrier family 35, member F4 | -0.0331776 |
| KLHL29 | kelch-like family member 29 | -0.0331189 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0329869 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0327214 |
| LOC112694756 | uncharaterized LOC112694756 | -0.032257 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0322211 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0315073 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0313822 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0311138 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0309439 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0307833 |
| RPL6 | ribosomal protein L6 | -0.0306458 |
| BCL2 | B-cell CLL/lymphoma 2 | -0.0299483 |
| CCDC88A | coiled-coil domain containing 88A | -0.0298741 |
| CADM1 | cell adhesion molecule 1 | -0.0298147 |
| TPM4 | tropomyosin 4 | -0.0297356 |
| NFIA | nuclear factor I/A | -0.0294945 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0294734 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0294624 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0287588 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0287143 |
| AUTS2 | autism susceptibility candidate 2 | -0.0284335 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0280858 |
| FTL | ferritin, light polypeptide | -0.0278796 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0278369 |
| JAM3 | junctional adhesion molecule 3 | -0.0276456 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0273062 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0270619 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.026795 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0264977 |
| NELL1 | NEL-like 1 (chicken) | -0.0264281 |
| KCTD8 | potassium channel tetramerization domain containing 8 | -0.0262572 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0262177 |
| DENND1A | DENN/MADD domain containing 1A | -0.0260226 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | -0.0259653 |
| EPHA6 | EPH receptor A6 | -0.0258005 |
| ACTN4 | actinin, alpha 4 | -0.025714 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0256593 |
| JAZF1 | JAZF zinc finger 1 | -0.025658 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0254567 |
| RTN4 | reticulon 4 | -0.0253934 |
| AURKA | aurora kinase A | -0.0253338 |
| KIF14 | kinesin family member 14 | -0.0251156 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0250169 |
