RMC-6236_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description RMC-6236 perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the RMC-6236_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FMN1 formin 1 0.176153
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.123432
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0991332
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0940875
SFTPA2 surfactant protein A2 0.081416
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0747954
SPTBN1 spectrin, beta, non-erythrocytic 1 0.065046
AKAP12 A kinase (PRKA) anchor protein 12 0.0648014
FRMD4A FERM domain containing 4A 0.0559179
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0553844
IGFBP3 insulin-like growth factor binding protein 3 0.0540332
DST dystonin 0.0506359
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0498337
STAT1 signal transducer and activator of transcription 1, 91kDa 0.048299
RUNX1 runt-related transcription factor 1 0.0475528
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0475223
RNF213 ring finger protein 213 0.0450366
KDM3A lysine (K)-specific demethylase 3A 0.0447742
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0415036
FLNA filamin A, alpha 0.0410711
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0385194
SP100 SP100 nuclear antigen 0.0385194
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0385062
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0369432
SOX6 SRY (sex determining region Y)-box 6 0.0365876
AHNAK AHNAK nucleoprotein 0.0362943
MYH9 myosin, heavy chain 9, non-muscle 0.0361346
ZBTB20 zinc finger and BTB domain containing 20 0.0360911
SOX10 SRY (sex determining region Y)-box 10 0.0356975
HDAC9 histone deacetylase 9 0.0356862
IFI44L interferon-induced protein 44-like 0.0340636
MACF1 microtubule-actin crosslinking factor 1 0.0327507
EEF2 eukaryotic translation elongation factor 2 0.0322559
CANX calnexin 0.0314093
SQSTM1 sequestosome 1 0.0310304
FMNL2 formin-like 2 0.0309692
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0309323
TRIP12 thyroid hormone receptor interactor 12 0.0304631
HSPA8 heat shock 70kDa protein 8 0.029744
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0289513
LSAMP limbic system-associated membrane protein 0.0289207
GOLGB1 golgin B1 0.0287714
NAV2 neuron navigator 2 0.0286775
SPAG9 sperm associated antigen 9 0.0284302
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.028116
CSDE1 cold shock domain containing E1, RNA-binding 0.0277969
ZEB2 zinc finger E-box binding homeobox 2 0.02718
MACROD2 MACRO domain containing 2 0.0269377
MELTF melanotransferrin 0.0267434
OGA O-GlcNAcase 0.026736
ARRDC3 arrestin domain containing 3 0.0267333
KIF5B kinesin family member 5B 0.0264662
NRG3 neuregulin 3 0.0264163
LOC102724023 ES1 protein homolog, mitochondrial 0.026248
ZNF608 zinc finger protein 608 0.026239
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.026175
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0261556
B2M beta-2-microglobulin 0.0259301
BACE2 beta-site APP-cleaving enzyme 2 0.0258783
PLSCR1 phospholipid scramblase 1 0.0258318
SON SON DNA binding protein 0.0256709
NAMPT nicotinamide phosphoribosyltransferase 0.0254819
PRRC2C proline-rich coiled-coil 2C 0.0254382
NAP1L1 nucleosome assembly protein 1-like 1 0.0253799
SRRM2 serine/arginine repetitive matrix 2 0.0253005
ADAR adenosine deaminase, RNA-specific 0.0249201
IFI16 interferon, gamma-inducible protein 16 0.0248743
PTPRM protein tyrosine phosphatase, receptor type, M 0.0248186
ANKRD28 ankyrin repeat domain 28 0.0245839
OSBPL10 oxysterol binding protein-like 10 0.0245736
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.024573
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0245261
RRBP1 ribosome binding protein 1 0.0244508
CHD1 chromodomain helicase DNA binding protein 1 0.02442
MAN1A2 mannosidase, alpha, class 1A, member 2 0.0243415
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0243413
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0242825
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 0.0238646
KTN1 kinectin 1 (kinesin receptor) 0.0236647
ANXA2 annexin A2 0.0232404
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0230984
MKI67 marker of proliferation Ki-67 0.0229403
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0225647
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0225476
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0222237
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.022178
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0221313
QKI QKI, KH domain containing, RNA binding 0.0219353
NFE2L2 nuclear factor, erythroid 2-like 2 0.0219217
LAMP2 lysosomal-associated membrane protein 2 0.0219113
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0217472
CRYBG3 beta-gamma crystallin domain containing 3 0.0217083
EXOC4 exocyst complex component 4 0.0216499
CD59 CD59 molecule, complement regulatory protein 0.0216418
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0215351
ELL2 elongation factor, RNA polymerase II, 2 0.0214128
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0212239
TRIO trio Rho guanine nucleotide exchange factor 0.0211629
SAMD9 sterile alpha motif domain containing 9 0.0210469
CD164 CD164 molecule, sialomucin 0.0210291

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.294315
FN1 fibronectin 1 -0.232601
VIM vimentin -0.123697
NLGN1 neuroligin 1 -0.0940241
MT2A metallothionein 2A -0.0881792
POTEF POTE ankyrin domain family, member F -0.081649
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0700495
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0638536
ACTG1 actin gamma 1 -0.0613932
TMSB10 thymosin beta 10 -0.0515994
RPS6 ribosomal protein S6 -0.0508659
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.047802
FTL ferritin, light polypeptide -0.0435176
SREBF2 sterol regulatory element binding transcription factor 2 -0.0430728
RPLP1 ribosomal protein, large, P1 -0.0401386
S100A9 S100 calcium binding protein A9 -0.0387112
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0384767
PTMA prothymosin, alpha -0.0376435
RPS23 ribosomal protein S23 -0.0367768
CDH13 cadherin 13 -0.0336047
HMGA1 high mobility group AT-hook 1 -0.0322386
PKM pyruvate kinase, muscle -0.0316969
RPS21 ribosomal protein S21 -0.0312914
RPLP2 ribosomal protein, large, P2 -0.0309277
TUBA1B tubulin, alpha 1b -0.030744
CTSD cathepsin D -0.0305293
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0288875
S100A6 S100 calcium binding protein A6 -0.0284188
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0281614
RPL38 ribosomal protein L38 -0.0280542
RPS24 ribosomal protein S24 -0.0279723
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0274749
TNNC1 troponin C type 1 (slow) -0.0268601
RPL35A ribosomal protein L35a -0.026669
TIMP2 TIMP metallopeptidase inhibitor 2 -0.026129
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0260502
RPS11 ribosomal protein S11 -0.0259125
RPL32 ribosomal protein L32 -0.0254254
PGK1 phosphoglycerate kinase 1 -0.0247113
RPS29 ribosomal protein S29 -0.0245421
RPL23 ribosomal protein L23 -0.024501
RPL36A ribosomal protein L36a -0.0242403
TUBB tubulin, beta class I -0.0240899
S100A10 S100 calcium binding protein A10 -0.0240481
RPS15 ribosomal protein S15 -0.0239135
CCND1 cyclin D1 -0.0237533
PFN1 profilin 1 -0.0235533
RPL19 ribosomal protein L19 -0.0232682
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0230714
RPL28 ribosomal protein L28 -0.0229632
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0222574
RPS19 ribosomal protein S19 -0.0221782
MMP12 matrix metallopeptidase 12 -0.02207
RPL34 ribosomal protein L34 -0.0216306
RPS5 ribosomal protein S5 -0.0211047
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0209831
GNAS GNAS complex locus -0.020867
KPNB1 karyopherin (importin) beta 1 -0.0208189
RPL27A ribosomal protein L27a -0.0206946
PDIA3 protein disulfide isomerase family A, member 3 -0.0206307
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0205735
MT1X metallothionein 1X -0.0205733
NHSL1 NHS-like 1 -0.0202474
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0201732
RPS13 ribosomal protein S13 -0.0201432
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0199802
ASTN2 astrotactin 2 -0.019915
CD63 CD63 molecule -0.0198076
NOTCH2 notch 2 -0.0196788
BSG basigin (Ok blood group) -0.0196032
RTN4 reticulon 4 -0.01959
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0194266
SNU13 small nuclear ribonucleoprotein 13 -0.0192405
CBX3 chromobox homolog 3 -0.0192223
ACTN4 actinin, alpha 4 -0.0191292
TPM4 tropomyosin 4 -0.0189681
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0189065
RPS14 ribosomal protein S14 -0.0185298
SBF2 SET binding factor 2 -0.0184109
RPS10 ribosomal protein S10 -0.0182964
TAPBP TAP binding protein (tapasin) -0.0182695
ZMYND8 zinc finger, MYND-type containing 8 -0.018182
ZNF207 zinc finger protein 207 -0.0181317
RPLP0 ribosomal protein, large, P0 -0.0179172
RPS16 ribosomal protein S16 -0.0176979
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.017657
FOSL1 FOS-like antigen 1 -0.0175434
CYB5R3 cytochrome b5 reductase 3 -0.0173543
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0172779
RBMX RNA binding motif protein, X-linked -0.0172118
VDAC1 voltage-dependent anion channel 1 -0.0170501
PDCD10 programmed cell death 10 -0.0169481
LOC112694756 uncharaterized LOC112694756 -0.0169153
PDE4D phosphodiesterase 4D, cAMP-specific -0.0168897
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0166633
MAML3 mastermind-like 3 (Drosophila) -0.016491
LDHB lactate dehydrogenase B -0.0164218
TAOK1 TAO kinase 1 -0.0164051
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -0.0163148
ATF7IP activating transcription factor 7 interacting protein -0.016293