RMC-6236_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description RMC-6236 perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the RMC-6236_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.164937
MYH9 myosin, heavy chain 9, non-muscle 0.0804377
EEF2 eukaryotic translation elongation factor 2 0.0723533
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0597407
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0557638
HDAC9 histone deacetylase 9 0.0526371
ARRDC3 arrestin domain containing 3 0.0511404
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0486155
BICC1 BicC family RNA binding protein 1 0.048185
SFTPA2 surfactant protein A2 0.0481327
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0471324
VCAN versican 0.041242
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0395091
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0380771
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0373904
SMAD3 SMAD family member 3 0.0371201
LOC102724023 ES1 protein homolog, mitochondrial 0.0347094
TMSB4X thymosin beta 4, X-linked 0.0337568
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0333252
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0326152
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0266724
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0265059
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0260681
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0251308
CD44 CD44 molecule (Indian blood group) 0.0249414
COL6A3 collagen, type VI, alpha 3 0.0248554
SYNJ2 synaptojanin 2 0.0241789
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0234631
ZBTB38 zinc finger and BTB domain containing 38 0.0233667
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0232113
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0231575
TXNIP thioredoxin interacting protein 0.0230382
RUNX1 runt-related transcription factor 1 0.0229975
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0226574
CTSB cathepsin B 0.0225572
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0222019
VEGFA vascular endothelial growth factor A 0.0210603
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0210458
FLNA filamin A, alpha 0.0209485
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0204849
ATF3 activating transcription factor 3 0.0204245
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0203492
MX1 MX dynamin-like GTPase 1 0.0194429
THBS1 thrombospondin 1 0.0194327
STC1 stanniocalcin 1 0.0194089
TRIM55 tripartite motif containing 55 0.0193517
WEE1 WEE1 G2 checkpoint kinase 0.0187553
SVIL supervillin 0.0186367
MBNL1 muscleblind-like splicing regulator 1 0.018233
NAMPT nicotinamide phosphoribosyltransferase 0.0181404
ANKRD28 ankyrin repeat domain 28 0.0179533
SHB Src homology 2 domain containing adaptor protein B 0.0178945
SRRM2 serine/arginine repetitive matrix 2 0.0175265
PLSCR1 phospholipid scramblase 1 0.0174446
SAMD9 sterile alpha motif domain containing 9 0.0167796
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0167387
IFI16 interferon, gamma-inducible protein 16 0.0166164
BIRC3 baculoviral IAP repeat containing 3 0.0161129
NFE2L2 nuclear factor, erythroid 2-like 2 0.0157241
PCBP2 poly(rC) binding protein 2 0.0156229
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0151353
KLF6 Kruppel-like factor 6 0.0148882
IGFBP7 insulin-like growth factor binding protein 7 0.0147014
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.014566
EIF4B eukaryotic translation initiation factor 4B 0.0144127
MT1X metallothionein 1X 0.0144094
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0139367
GPC6 glypican 6 0.013883
RIGI RNA sensor RIG-I 0.0138551
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0138526
USP9X ubiquitin specific peptidase 9, X-linked 0.0138322
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0136699
NFE2L1 nuclear factor, erythroid 2-like 1 0.0130294
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0129514
PCLO piccolo presynaptic cytomatrix protein 0.0128682
RPS2 ribosomal protein S2 0.0127032
SON SON DNA binding protein 0.0127002
HSPA8 heat shock 70kDa protein 8 0.0126949
IL1R1 interleukin 1 receptor, type I 0.0126695
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.012589
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0125193
BASP1 brain abundant, membrane attached signal protein 1 0.0121012
RPS18 ribosomal protein S18 0.0118236
CD59 CD59 molecule, complement regulatory protein 0.0117624
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0117544
TPM3 tropomyosin 3 0.0117178
SOX9 SRY (sex determining region Y)-box 9 0.0116777
ZNF608 zinc finger protein 608 0.0116527
AHNAK2 AHNAK nucleoprotein 2 0.0114413
GPR176 G protein-coupled receptor 176 0.0113243
CREB5 cAMP responsive element binding protein 5 0.011317
PLIN2 perilipin 2 0.0111631
NTN4 netrin 4 0.0111351
ADAR adenosine deaminase, RNA-specific 0.0110908
TGFBR1 transforming growth factor, beta receptor 1 0.0108964
SP100 SP100 nuclear antigen 0.0108529
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0107383
METTL15 methyltransferase like 15 0.0106746
PMP22 peripheral myelin protein 22 0.0106527
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0106104

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.259962
VIM vimentin -0.223803
HLA-B major histocompatibility complex, class I, B -0.134018
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.111408
FTL ferritin, light polypeptide -0.107711
SOD2 superoxide dismutase 2, mitochondrial -0.105175
IER3 immediate early response 3 -0.104106
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0966711
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0957512
TPT1 tumor protein, translationally-controlled 1 -0.0913407
RPS6 ribosomal protein S6 -0.0841215
PTMA prothymosin, alpha -0.0793877
TMSB10 thymosin beta 10 -0.0761662
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.074133
FRMD4A FERM domain containing 4A -0.0697932
CADM1 cell adhesion molecule 1 -0.067497
RPS8 ribosomal protein S8 -0.0565232
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0552991
RPS24 ribosomal protein S24 -0.0541857
ACTG1 actin gamma 1 -0.0521384
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0520845
GNAS GNAS complex locus -0.0520499
SDK1 sidekick cell adhesion molecule 1 -0.0520054
RPS23 ribosomal protein S23 -0.0515956
TRIO trio Rho guanine nucleotide exchange factor -0.0510105
FRMPD4 FERM and PDZ domain containing 4 -0.0501481
ZMYND8 zinc finger, MYND-type containing 8 -0.0499299
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0491107
HLA-A major histocompatibility complex, class I, A -0.0487453
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0473996
RPL35A ribosomal protein L35a -0.0468669
SLC38A2 solute carrier family 38, member 2 -0.0464664
NDRG1 N-myc downstream regulated 1 -0.046314
IGFBP3 insulin-like growth factor binding protein 3 -0.0454602
RPL37A ribosomal protein L37a -0.044376
PDE10A phosphodiesterase 10A -0.0441842
TPM4 tropomyosin 4 -0.0434451
RPL23 ribosomal protein L23 -0.0430851
RPLP2 ribosomal protein, large, P2 -0.0430076
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0425991
RPL36A ribosomal protein L36a -0.0420811
RPLP1 ribosomal protein, large, P1 -0.0407766
PGK1 phosphoglycerate kinase 1 -0.0396516
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0396402
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0395235
RPS13 ribosomal protein S13 -0.0395028
RPS25 ribosomal protein S25 -0.038311
RPL31 ribosomal protein L31 -0.0378217
CTSD cathepsin D -0.0373959
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0372556
ZFAND3 zinc finger, AN1-type domain 3 -0.036657
RAB1A RAB1A, member RAS oncogene family -0.0365566
RPS29 ribosomal protein S29 -0.035772
GOLGA4 golgin A4 -0.0357629
DIAPH2 diaphanous-related formin 2 -0.0353736
INSIG1 insulin induced gene 1 -0.0336234
WSB1 WD repeat and SOCS box containing 1 -0.0332611
DST dystonin -0.0331048
UBC ubiquitin C -0.0331001
PKM pyruvate kinase, muscle -0.0326223
NPEPPS aminopeptidase puromycin sensitive -0.0323909
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0318117
KPNB1 karyopherin (importin) beta 1 -0.0317477
UGCG UDP-glucose ceramide glucosyltransferase -0.0314911
RPS10 ribosomal protein S10 -0.031377
RPL38 ribosomal protein L38 -0.0312469
FBXO11 F-box protein 11 -0.0311691
RPS19 ribosomal protein S19 -0.0304793
AFF3 AF4/FMR2 family, member 3 -0.0301783
EGFR epidermal growth factor receptor -0.0300822
WTAP Wilms tumor 1 associated protein -0.0299301
RTN4 reticulon 4 -0.0298009
ELL2 elongation factor, RNA polymerase II, 2 -0.0297207
RAI14 retinoic acid induced 14 -0.029711
ENO2 enolase 2 (gamma, neuronal) -0.0295168
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0293461
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0292334
SETD5 SET domain containing 5 -0.0288134
SLC38A1 solute carrier family 38, member 1 -0.0285495
RPL9 ribosomal protein L9 -0.0285253
ABI3BP ABI family, member 3 (NESH) binding protein -0.0283563
FNDC3B fibronectin type III domain containing 3B -0.0282357
CDH13 cadherin 13 -0.0279969
RPL7A ribosomal protein L7a -0.0279632
LOX lysyl oxidase -0.0279142
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.027791
TAOK1 TAO kinase 1 -0.0275674
RPS21 ribosomal protein S21 -0.0274189
RPL34 ribosomal protein L34 -0.0274159
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0271933
HMGA1 high mobility group AT-hook 1 -0.0271903
DLG1 discs, large homolog 1 (Drosophila) -0.0270131
RPL19 ribosomal protein L19 -0.0269657
TUBB tubulin, beta class I -0.0269529
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0269043
KDM5B lysine (K)-specific demethylase 5B -0.0265017
EGR1 early growth response 1 -0.0262844
BTG1 B-cell translocation gene 1, anti-proliferative -0.0262788
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0261341
SPDYA speedy/RINGO cell cycle regulator family member A -0.0260696