RMC-6236_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description RMC-6236 perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the RMC-6236_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.145555
ERRFI1 ERBB receptor feedback inhibitor 1 0.131048
COL6A3 collagen, type VI, alpha 3 0.123753
MYH9 myosin, heavy chain 9, non-muscle 0.116901
CD44 CD44 molecule (Indian blood group) 0.0853102
NAMPT nicotinamide phosphoribosyltransferase 0.0789404
AHNAK AHNAK nucleoprotein 0.0676354
ELL2 elongation factor, RNA polymerase II, 2 0.0601723
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0565049
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0489505
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0485647
B2M beta-2-microglobulin 0.0471701
SFTPA2 surfactant protein A2 0.0469646
NRXN3 neurexin 3 0.0447003
ARRDC3 arrestin domain containing 3 0.0442595
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.043539
BBS9 Bardet-Biedl syndrome 9 0.0426635
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0408472
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0404616
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0390899
ZBTB20 zinc finger and BTB domain containing 20 0.038904
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0388641
EXT1 exostosin glycosyltransferase 1 0.0385581
CANX calnexin 0.0383628
MACF1 microtubule-actin crosslinking factor 1 0.0382301
SMYD3 SET and MYND domain containing 3 0.0371992
HIP1 huntingtin interacting protein 1 0.0363818
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0355812
SDC4 syndecan 4 0.0355459
SMAD3 SMAD family member 3 0.0353851
GLS2 glutaminase 2 (liver, mitochondrial) 0.0353838
APP amyloid beta (A4) precursor protein 0.0352915
SOD2 superoxide dismutase 2, mitochondrial 0.0350551
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0342954
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0333041
IGFBP7 insulin-like growth factor binding protein 7 0.0332991
GOLGB1 golgin B1 0.0328178
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.032795
STC1 stanniocalcin 1 0.0327665
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0326914
PLEC plectin 0.032665
GSE1 Gse1 coiled-coil protein 0.0320644
FLNA filamin A, alpha 0.0317623
CYLD cylindromatosis (turban tumor syndrome) 0.0309566
SAMD4A sterile alpha motif domain containing 4A 0.0309476
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0308536
EEF2 eukaryotic translation elongation factor 2 0.030413
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.029831
SHB Src homology 2 domain containing adaptor protein B 0.0296522
VMP1 vacuole membrane protein 1 0.0296139
EMP1 epithelial membrane protein 1 0.0287264
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0285859
VCL vinculin 0.0283767
MYOF myoferlin 0.0282414
ATP13A3 ATPase type 13A3 0.0281355
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0278087
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0269441
MBNL2 muscleblind-like splicing regulator 2 0.026654
MSN moesin 0.0265696
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0265584
CD59 CD59 molecule, complement regulatory protein 0.026498
MYLK myosin light chain kinase 0.0261694
CALR calreticulin 0.0258421
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.025258
STK17A serine/threonine kinase 17a 0.0251464
TXNIP thioredoxin interacting protein 0.0250154
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0249899
LPP LIM domain containing preferred translocation partner in lipoma 0.0249157
TRA2A transformer 2 alpha homolog (Drosophila) 0.0247981
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0239003
JAG1 jagged 1 0.0238542
SCFD1 sec1 family domain containing 1 0.0237191
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0236974
AHR aryl hydrocarbon receptor 0.0236563
RICTOR RPTOR independent companion of MTOR, complex 2 0.0232612
SPAG9 sperm associated antigen 9 0.0230494
AKAP9 A kinase (PRKA) anchor protein 9 0.0226662
OSBPL8 oxysterol binding protein-like 8 0.0221204
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0219313
KYNU kynureninase 0.0218496
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.021812
THRAP3 thyroid hormone receptor associated protein 3 0.0217826
PRRC2C proline-rich coiled-coil 2C 0.0211567
MORF4L2 mortality factor 4 like 2 0.0210917
EGFR epidermal growth factor receptor 0.0210572
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0208244
TTC3 tetratricopeptide repeat domain 3 0.020793
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.020486
ABLIM3 actin binding LIM protein family, member 3 0.0204611
MARCHF6 membrane associated ring-CH-type finger 6 0.0203884
HOOK2 hook microtubule-tethering protein 2 0.0201729
CXXC5 CXXC finger protein 5 0.0200467
PDLIM5 PDZ and LIM domain 5 0.0199507
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0199211
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0198465
GCC2 GRIP and coiled-coil domain containing 2 0.0197284
STK4 serine/threonine kinase 4 0.0197069
CSDE1 cold shock domain containing E1, RNA-binding 0.019563
CTNND1 catenin (cadherin-associated protein), delta 1 0.019557
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0195402

decreased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 -0.181776
IGFBP3 insulin-like growth factor binding protein 3 -0.15403
POTEF POTE ankyrin domain family, member F -0.130104
VIM vimentin -0.124608
TGFBI transforming growth factor, beta-induced, 68kDa -0.119499
F3 coagulation factor III (thromboplastin, tissue factor) -0.117087
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.114684
FN1 fibronectin 1 -0.0900632
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0882281
TMSB10 thymosin beta 10 -0.0846216
HLA-B major histocompatibility complex, class I, B -0.0801486
COL1A1 collagen, type I, alpha 1 -0.0756045
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0726354
IL6 interleukin 6 -0.0724798
ENO1 enolase 1, (alpha) -0.0662642
ASPH aspartate beta-hydroxylase -0.0660184
PKM pyruvate kinase, muscle -0.0581988
SEPTIN7 septin 7 -0.0554416
FTL ferritin, light polypeptide -0.0510793
COL6A1 collagen, type VI, alpha 1 -0.0505011
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0480341
PTMA prothymosin, alpha -0.0476836
PDIA3 protein disulfide isomerase family A, member 3 -0.0471707
RPS6 ribosomal protein S6 -0.0466269
TPT1 tumor protein, translationally-controlled 1 -0.0452574
COL1A2 collagen, type I, alpha 2 -0.0419977
ZMYND8 zinc finger, MYND-type containing 8 -0.039481
ACTG1 actin gamma 1 -0.0381559
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0377601
S100A9 S100 calcium binding protein A9 -0.0368307
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0367029
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0356983
MMP12 matrix metallopeptidase 12 -0.0355764
ZNF395 zinc finger protein 395 -0.034233
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0334416
AFF3 AF4/FMR2 family, member 3 -0.0328176
CCDC88A coiled-coil domain containing 88A -0.0319535
S100A6 S100 calcium binding protein A6 -0.0318842
CCDC14 coiled-coil domain containing 14 -0.0318724
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0313064
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0310677
NDRG1 N-myc downstream regulated 1 -0.0305455
PDE4D phosphodiesterase 4D, cAMP-specific -0.0305385
TENM3 teneurin transmembrane protein 3 -0.0305366
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0305084
COL5A2 collagen, type V, alpha 2 -0.0296499
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0295666
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0294011
RAD51B RAD51 paralog B -0.0292942
FOSL1 FOS-like antigen 1 -0.0289185
TUBB tubulin, beta class I -0.0279519
DIAPH3 diaphanous-related formin 3 -0.0276574
MT2A metallothionein 2A -0.0272422
UBC ubiquitin C -0.026563
VDAC1 voltage-dependent anion channel 1 -0.0265491
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0262515
FUS FUS RNA binding protein -0.0259509
CDH13 cadherin 13 -0.0259494
FGFR1 fibroblast growth factor receptor 1 -0.025911
RPS11 ribosomal protein S11 -0.0258826
TAS2R14 taste receptor, type 2, member 14 -0.025825
HLA-A major histocompatibility complex, class I, A -0.0257244
KMT2C lysine (K)-specific methyltransferase 2C -0.025683
RPL35A ribosomal protein L35a -0.0253358
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0252327
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -0.0248055
ANLN anillin, actin binding protein -0.0247259
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0246216
PFN1 profilin 1 -0.0245675
BBX bobby sox homolog (Drosophila) -0.0244558
HSPB1 heat shock 27kDa protein 1 -0.024407
RPL9 ribosomal protein L9 -0.0241177
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0240776
RPL19 ribosomal protein L19 -0.0240339
CENPE centromere protein E, 312kDa -0.0237829
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0236077
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0232772
CUX1 cut-like homeobox 1 -0.023245
CKAP4 cytoskeleton-associated protein 4 -0.0228907
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0224359
HP1BP3 heterochromatin protein 1, binding protein 3 -0.02242
TUBA1B tubulin, alpha 1b -0.0224062
ANKRD12 ankyrin repeat domain 12 -0.0222625
GNAS GNAS complex locus -0.0221193
PGK1 phosphoglycerate kinase 1 -0.0220018
PTPRG protein tyrosine phosphatase, receptor type, G -0.0219775
RPL27A ribosomal protein L27a -0.0217999
RPLP1 ribosomal protein, large, P1 -0.0217755
RPL34 ribosomal protein L34 -0.0217008
NIPBL Nipped-B homolog (Drosophila) -0.0216027
EGR1 early growth response 1 -0.021579
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0215329
CENPF centromere protein F, 350/400kDa -0.0214498
RPS13 ribosomal protein S13 -0.0210696
DTNA dystrobrevin, alpha -0.0209455
DEK DEK proto-oncogene -0.0209311
CCNI cyclin I -0.020846
TENT5A terminal nucleotidyltransferase 5A -0.0207597
CD99 CD99 molecule -0.0206622
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0205995