| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the RMC-6236_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.134456 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.080013 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0751143 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0745889 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0668259 |
| INTS6 | integrator complex subunit 6 | 0.0602333 |
| TXNRD1 | thioredoxin reductase 1 | 0.0581166 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0555925 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0483523 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0480792 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0458905 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0456746 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0430111 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0409248 |
| TXNIP | thioredoxin interacting protein | 0.0382795 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0372079 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0338727 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0336911 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0310019 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0308014 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0307505 |
| RPS12 | ribosomal protein S12 | 0.0303861 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0303157 |
| TPI1 | triosephosphate isomerase 1 | 0.0298758 |
| OXSR1 | oxidative stress responsive 1 | 0.02916 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.02843 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0259097 |
| TLE4 | transducin-like enhancer of split 4 | 0.0252998 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0251886 |
| FTL | ferritin, light polypeptide | 0.0251162 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0250534 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0246979 |
| SIK2 | salt-inducible kinase 2 | 0.0242112 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0241817 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0233595 |
| ATF3 | activating transcription factor 3 | 0.0231009 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.022811 |
| SET | SET nuclear proto-oncogene | 0.0219343 |
| AHR | aryl hydrocarbon receptor | 0.0214104 |
| B2M | beta-2-microglobulin | 0.0212848 |
| RIOK3 | RIO kinase 3 | 0.021281 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0211342 |
| DUSP12 | dual specificity phosphatase 12 | 0.0207701 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0200907 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0199927 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0199845 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.0199812 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0187914 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.018416 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0183835 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0181692 |
| TM9SF4 | transmembrane 9 superfamily protein member 4 | 0.018035 |
| SIK3 | SIK family kinase 3 | 0.0180126 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0179409 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0178944 |
| CPNE1 | copine I | 0.0177255 |
| RPS3 | ribosomal protein S3 | 0.017633 |
| SPAG16 | sperm associated antigen 16 | 0.0173746 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0171853 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0171508 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0171255 |
| LATS2 | large tumor suppressor kinase 2 | 0.0170789 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0167654 |
| RAB31 | RAB31, member RAS oncogene family | 0.0167553 |
| IPO7 | importin 7 | 0.0166907 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0166725 |
| MED13L | mediator complex subunit 13-like | 0.0165555 |
| ARRDC3 | arrestin domain containing 3 | 0.0164948 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0164826 |
| SMAD3 | SMAD family member 3 | 0.0164783 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0164782 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0162532 |
| LMNA | lamin A/C | 0.016008 |
| MYOF | myoferlin | 0.015883 |
| GPHN | gephyrin | 0.015669 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0156513 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.015645 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0156009 |
| SFTPA2 | surfactant protein A2 | 0.0155963 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0153384 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0152967 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0150823 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0149823 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0148346 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0148155 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0147406 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0147392 |
| RPL23 | ribosomal protein L23 | 0.0147319 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0146728 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0146618 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0146599 |
| KANSL1L | KAT8 regulatory NSL complex subunit 1-like | 0.0144159 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0143964 |
| RPS17 | ribosomal protein S17 | 0.014291 |
| BRD2 | bromodomain containing 2 | 0.014251 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0141398 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0141094 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0140886 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0140721 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | 0.0140256 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.263926 |
| FNDC3B | fibronectin type III domain containing 3B | -0.132147 |
| VIM | vimentin | -0.119937 |
| TMSB10 | thymosin beta 10 | -0.104113 |
| HMGA2 | high mobility group AT-hook 2 | -0.0827243 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0798666 |
| FLNB | filamin B, beta | -0.0765998 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0706219 |
| NF1 | neurofibromin 1 | -0.0700023 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0652215 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0650515 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.06305 |
| EFNA5 | ephrin-A5 | -0.0623177 |
| CAPRIN2 | caprin family member 2 | -0.0609365 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0597625 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0592305 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0574287 |
| DNER | delta/notch-like EGF repeat containing | -0.0570087 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0564575 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.055923 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0557306 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0548747 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0548127 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0546911 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0535297 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0527059 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0525732 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0507543 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0497923 |
| ANGPTL4 | angiopoietin-like 4 | -0.0493674 |
| ATG7 | autophagy related 7 | -0.0493614 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.04917 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0490628 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0490178 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0489816 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0488746 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0487174 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0477866 |
| ACTN1 | actinin, alpha 1 | -0.0469323 |
| ATM | ATM serine/threonine kinase | -0.0457678 |
| NALCN | sodium leak channel, non selective | -0.0455599 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0453701 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0450031 |
| SETD5 | SET domain containing 5 | -0.0447448 |
| DST | dystonin | -0.0442051 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0441984 |
| PTK2 | protein tyrosine kinase 2 | -0.0438502 |
| ERBIN | erbb2 interacting protein | -0.0437093 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0436721 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0436561 |
| PDE8A | phosphodiesterase 8A | -0.0434184 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0433703 |
| RBM39 | RNA binding motif protein 39 | -0.0433271 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.04325 |
| RIN2 | Ras and Rab interactor 2 | -0.0430698 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0425317 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0425037 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0419247 |
| ASPH | aspartate beta-hydroxylase | -0.0418358 |
| PYGL | phosphorylase, glycogen, liver | -0.0417875 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0417713 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0409145 |
| MT2A | metallothionein 2A | -0.0407357 |
| PARD3 | par-3 family cell polarity regulator | -0.0404196 |
| TPM4 | tropomyosin 4 | -0.039913 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0395367 |
| NKTR | natural killer cell triggering receptor | -0.0393787 |
| PCED1B | PC-esterase domain containing 1B | -0.0393071 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0392346 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0376843 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0374426 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0373977 |
| TAOK1 | TAO kinase 1 | -0.03724 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0366215 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0365647 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0361737 |
| IGF2 | insulin-like growth factor 2 | -0.0358857 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.035698 |
| GPC6 | glypican 6 | -0.0356588 |
| PRR16 | proline rich 16 | -0.0354657 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0352873 |
| DERA | deoxyribose-phosphate aldolase (putative) | -0.0352622 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0352265 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0349028 |
| TMEM263 | transmembrane protein 263 | -0.0345709 |
| SEPTIN7 | septin 7 | -0.0343155 |
| NDRG1 | N-myc downstream regulated 1 | -0.0340376 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0340327 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.034004 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0336817 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0335668 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0335613 |
| NGLY1 | N-glycanase 1 | -0.0333445 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0332361 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -0.033229 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0331649 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0329404 |
| ATXN1 | ataxin 1 | -0.0328463 |
| ZNF609 | zinc finger protein 609 | -0.0325008 |
| SDC4 | syndecan 4 | -0.0325001 |
