| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the RMC-6236_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.185715 |
| STC2 | stanniocalcin 2 | 0.126156 |
| SFTPA2 | surfactant protein A2 | 0.0763329 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0725269 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0669092 |
| PLIN2 | perilipin 2 | 0.0630077 |
| B2M | beta-2-microglobulin | 0.0552239 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0526506 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0485696 |
| HMGA2 | high mobility group AT-hook 2 | 0.0463349 |
| NRG1 | neuregulin 1 | 0.0450638 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0449005 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0426593 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0421621 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0415251 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0404677 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0396727 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0396545 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0379471 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.037576 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0369439 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0355006 |
| MYOF | myoferlin | 0.0351253 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0336311 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0323299 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0319644 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0306907 |
| LMNA | lamin A/C | 0.0302837 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0299728 |
| EFNA5 | ephrin-A5 | 0.0297387 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0290261 |
| FAT1 | FAT atypical cadherin 1 | 0.0289647 |
| TCIM | transcriptional and immune response regulator | 0.0289276 |
| DSTN | destrin (actin depolymerizing factor) | 0.0288588 |
| TMSB4X | thymosin beta 4, X-linked | 0.0278152 |
| MYADM | myeloid-associated differentiation marker | 0.0257405 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0252676 |
| FAM107B | family with sequence similarity 107, member B | 0.0247885 |
| IFI44L | interferon-induced protein 44-like | 0.0246338 |
| ATF3 | activating transcription factor 3 | 0.0245788 |
| LYST | lysosomal trafficking regulator | 0.0244823 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0238259 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0229874 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0228183 |
| CTSB | cathepsin B | 0.0225694 |
| LOXL2 | lysyl oxidase-like 2 | 0.0213526 |
| AEBP2 | AE binding protein 2 | 0.021244 |
| INTS6 | integrator complex subunit 6 | 0.0211837 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0209881 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 0.0207022 |
| TXNIP | thioredoxin interacting protein | 0.0206553 |
| RASAL2 | RAS protein activator like 2 | 0.0205365 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0202188 |
| FBN1 | fibrillin 1 | 0.0199795 |
| FAM13A | family with sequence similarity 13, member A | 0.0196254 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0195175 |
| SGMS2 | sphingomyelin synthase 2 | 0.0193447 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0192334 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0192257 |
| VEGFA | vascular endothelial growth factor A | 0.018969 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0183306 |
| LAMB3 | laminin, beta 3 | 0.0182922 |
| EMP1 | epithelial membrane protein 1 | 0.0182814 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0177136 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0173249 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0171849 |
| EGFR | epidermal growth factor receptor | 0.0168675 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0168545 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0166579 |
| CTBP2 | C-terminal binding protein 2 | 0.016579 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0165386 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0163204 |
| GPR176 | G protein-coupled receptor 176 | 0.0163064 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0162226 |
| NXN | nucleoredoxin | 0.0162074 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0159745 |
| GPATCH2L | G patch domain containing 2-like | 0.0158228 |
| AHRR | aryl-hydrocarbon receptor repressor | 0.0157383 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | 0.0156525 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0155097 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0155049 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0152329 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0152281 |
| HLA-E | major histocompatibility complex, class I, E | 0.0149311 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0148835 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0148268 |
| ATF6 | activating transcription factor 6 | 0.0148213 |
| IRS2 | insulin receptor substrate 2 | 0.0148095 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0147759 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0147495 |
| POU2F2 | POU class 2 homeobox 2 | 0.0147433 |
| DUSP6 | dual specificity phosphatase 6 | 0.0146768 |
| ENO1 | enolase 1, (alpha) | 0.0145965 |
| ZBTB1 | zinc finger and BTB domain containing 1 | 0.0145327 |
| RPS27 | ribosomal protein S27 | 0.0144281 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0142252 |
| RUNX1 | runt-related transcription factor 1 | 0.0140509 |
| CRTAC1 | cartilage acidic protein 1 | 0.0138688 |
| ABR | active BCR-related | 0.0138385 |
| FHIT | fragile histidine triad | 0.0138064 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.396293 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.24941 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.107335 |
| FN1 | fibronectin 1 | -0.0854094 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0753141 |
| VCL | vinculin | -0.0669529 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0615805 |
| RTN4 | reticulon 4 | -0.0581311 |
| RBM39 | RNA binding motif protein 39 | -0.0574839 |
| SQSTM1 | sequestosome 1 | -0.0550891 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0546505 |
| OGA | O-GlcNAcase | -0.0542849 |
| DST | dystonin | -0.0539278 |
| OSMR | oncostatin M receptor | -0.0532994 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0518507 |
| VMP1 | vacuole membrane protein 1 | -0.0514133 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0512625 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0504756 |
| NRP1 | neuropilin 1 | -0.0503495 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.049006 |
| CENPF | centromere protein F, 350/400kDa | -0.047586 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0470865 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0470771 |
| AHR | aryl hydrocarbon receptor | -0.046153 |
| TXNRD1 | thioredoxin reductase 1 | -0.0450162 |
| COPA | coatomer protein complex, subunit alpha | -0.0448714 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0448201 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0446295 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0441685 |
| SMOX | spermine oxidase | -0.0437025 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0437016 |
| SPAG9 | sperm associated antigen 9 | -0.0434491 |
| MKI67 | marker of proliferation Ki-67 | -0.043415 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0419505 |
| RPS6 | ribosomal protein S6 | -0.0417626 |
| RUNX2 | runt-related transcription factor 2 | -0.0416438 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0416061 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0405775 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0405128 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0401513 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0399655 |
| ETNK1 | ethanolamine kinase 1 | -0.039618 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0387398 |
| ZNF292 | zinc finger protein 292 | -0.0384243 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.038189 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0380241 |
| JMJD1C | jumonji domain containing 1C | -0.0366312 |
| FNBP1 | formin binding protein 1 | -0.0364419 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0363984 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0357323 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0356272 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0353271 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0353172 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0353032 |
| GLIS3 | GLIS family zinc finger 3 | -0.0352178 |
| NEK7 | NIMA-related kinase 7 | -0.0351264 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0347961 |
| ADD3 | adducin 3 (gamma) | -0.0346611 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0344791 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0344493 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0339898 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0338354 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0336772 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0334412 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0330564 |
| TENT2 | terminal nucleotidyltransferase 2 | -0.0328921 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0327828 |
| WDR45B | WD repeat domain 45B | -0.0327025 |
| SETD5 | SET domain containing 5 | -0.0326215 |
| ACTN4 | actinin, alpha 4 | -0.0325174 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0324329 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0323277 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0322156 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0319352 |
| AOPEP | aminopeptidase O (putative) | -0.0317615 |
| SEPTIN7 | septin 7 | -0.0315853 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0315708 |
| RNF145 | ring finger protein 145 | -0.0315018 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.031457 |
| PELO | pelota homolog (Drosophila) | -0.0314318 |
| SUCO | SUN domain containing ossification factor | -0.0312425 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0312377 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0311731 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0309654 |
| PALLD | palladin, cytoskeletal associated protein | -0.030923 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0305631 |
| WDR26 | WD repeat domain 26 | -0.0304608 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0303907 |
| NUP58 | nucleoporin 58 | -0.0303349 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0303124 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0300986 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.030092 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0300308 |
| GNAS | GNAS complex locus | -0.0300127 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.029908 |
| RBM25 | RNA binding motif protein 25 | -0.0297778 |
| CD44 | CD44 molecule (Indian blood group) | -0.02967 |
| FBXW11 | F-box and WD repeat domain containing 11 | -0.0296472 |
| RHEB | Ras homolog enriched in brain | -0.0295915 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0294661 |
