| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | RMC-6236 perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the RMC-6236_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NEBL | nebulette | 0.114054 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0726446 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0716533 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0695459 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0660762 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0660134 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0644811 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.062915 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0580283 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0574462 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0554009 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0544104 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0529582 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0522451 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0521524 |
| RPS3 | ribosomal protein S3 | 0.0507105 |
| MED13L | mediator complex subunit 13-like | 0.0502466 |
| DSPP | dentin sialophosphoprotein | 0.0499644 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0493084 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0485905 |
| RBM39 | RNA binding motif protein 39 | 0.0482919 |
| CUL3 | cullin 3 | 0.0481784 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0476566 |
| H1-0 | H1.0 linker histone | 0.0469394 |
| VCL | vinculin | 0.0459534 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0450896 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0445159 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0433393 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0431996 |
| SMAD3 | SMAD family member 3 | 0.0423292 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.0420068 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0418701 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0418252 |
| PCBP2 | poly(rC) binding protein 2 | 0.0411432 |
| AFDN | afadin, adherens junction formation factor | 0.041025 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0409196 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0406034 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0404525 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0404496 |
| TRIM2 | tripartite motif containing 2 | 0.0402079 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0399395 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0380671 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0379463 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0375361 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0372317 |
| RPS2 | ribosomal protein S2 | 0.0371881 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0371877 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0368757 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0367859 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0352852 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0350889 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0349774 |
| TOP1 | topoisomerase (DNA) I | 0.0347297 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0344153 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0339728 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0339335 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0336218 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | 0.0334589 |
| MATR3 | matrin 3 | 0.0331317 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0330053 |
| SNX9 | sorting nexin 9 | 0.0325319 |
| FLNA | filamin A, alpha | 0.0325246 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0322889 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0322544 |
| MYO1E | myosin IE | 0.0320917 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0318645 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0317026 |
| TJP1 | tight junction protein 1 | 0.0314843 |
| LMTK2 | lemur tyrosine kinase 2 | 0.0314482 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0313245 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.030657 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0305858 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0305617 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0302849 |
| ATL2 | atlastin GTPase 2 | 0.0301395 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0300729 |
| RACK1 | receptor for activated C kinase 1 | 0.0296945 |
| JMJD1C | jumonji domain containing 1C | 0.0296568 |
| HMGB2 | high mobility group box 2 | 0.0293102 |
| NEK7 | NIMA-related kinase 7 | 0.0292985 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0290633 |
| PLEC | plectin | 0.0290296 |
| SIK3 | SIK family kinase 3 | 0.028854 |
| NCKAP1 | NCK-associated protein 1 | 0.028655 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0285372 |
| WWOX | WW domain containing oxidoreductase | 0.0284667 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0283567 |
| USP6NL | USP6 N-terminal like | 0.0281833 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0274363 |
| FHL2 | four and a half LIM domains 2 | 0.0271922 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.027188 |
| AHNAK | AHNAK nucleoprotein | 0.0271331 |
| RBM25 | RNA binding motif protein 25 | 0.0270801 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0269646 |
| SPAG9 | sperm associated antigen 9 | 0.0267926 |
| EVA1C | eva-1 homolog C (C. elegans) | 0.026629 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0263484 |
| KIF5B | kinesin family member 5B | 0.026281 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0259268 |
| TOM1L2 | target of myb1-like 2 (chicken) | 0.0258341 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.162616 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.108249 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.098428 |
| FTL | ferritin, light polypeptide | -0.0962055 |
| EGR1 | early growth response 1 | -0.0947602 |
| NDRG1 | N-myc downstream regulated 1 | -0.0858645 |
| TMEM123 | transmembrane protein 123 | -0.0775252 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0734372 |
| PTMA | prothymosin, alpha | -0.071168 |
| PKM | pyruvate kinase, muscle | -0.0694155 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0689221 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.068901 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0681473 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0608927 |
| GNAS | GNAS complex locus | -0.0603898 |
| LDHA | lactate dehydrogenase A | -0.0555565 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0546286 |
| TMSB10 | thymosin beta 10 | -0.0542989 |
| HLA-A | major histocompatibility complex, class I, A | -0.0506561 |
| KRT8 | keratin 8, type II | -0.0505963 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0471854 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0470994 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.044714 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0445807 |
| CTSD | cathepsin D | -0.0435277 |
| ITGB4 | integrin, beta 4 | -0.0424171 |
| PERP | PERP, TP53 apoptosis effector | -0.0421253 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.041186 |
| EHBP1 | EH domain binding protein 1 | -0.0391983 |
| HMGA1 | high mobility group AT-hook 1 | -0.0383647 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0379335 |
| FRMD5 | FERM domain containing 5 | -0.0368214 |
| HM13 | histocompatibility (minor) 13 | -0.0355307 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.034513 |
| FNDC3B | fibronectin type III domain containing 3B | -0.034501 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0341347 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | -0.0337646 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0330287 |
| MXD1 | MAX dimerization protein 1 | -0.0316709 |
| POTEF | POTE ankyrin domain family, member F | -0.0310312 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0304558 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0301593 |
| KRT19 | keratin 19, type I | -0.0296267 |
| HDAC9 | histone deacetylase 9 | -0.0296094 |
| PGK1 | phosphoglycerate kinase 1 | -0.0293482 |
| ANXA2 | annexin A2 | -0.0293411 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0290511 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0288005 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0283604 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0283393 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0283339 |
| CYP2S1 | cytochrome P450, family 2, subfamily S, polypeptide 1 | -0.0281063 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0269904 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0269768 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0268218 |
| TMEM47 | transmembrane protein 47 | -0.0267673 |
| SPNS2 | spinster homolog 2 (Drosophila) | -0.0266561 |
| JUP | junction plakoglobin | -0.0265419 |
| UBC | ubiquitin C | -0.0265067 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0264501 |
| FOSL1 | FOS-like antigen 1 | -0.0264097 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0263528 |
| NABP1 | nucleic acid binding protein 1 | -0.0259177 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0258695 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0258218 |
| NFIA | nuclear factor I/A | -0.0254695 |
| DEK | DEK proto-oncogene | -0.025275 |
| INTS6 | integrator complex subunit 6 | -0.0251254 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0247056 |
| S100A6 | S100 calcium binding protein A6 | -0.0243887 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0239283 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.0239092 |
| EZR | ezrin | -0.0236686 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0235347 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0234685 |
| CMIP | c-Maf inducing protein | -0.0230574 |
| USP34 | ubiquitin specific peptidase 34 | -0.0229417 |
| CD44 | CD44 molecule (Indian blood group) | -0.0227342 |
| CLDN3 | claudin 3 | -0.022653 |
| PFN1 | profilin 1 | -0.0225295 |
| TOB1 | transducer of ERBB2, 1 | -0.0221547 |
| TUBB | tubulin, beta class I | -0.0221434 |
| IER3 | immediate early response 3 | -0.0219167 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.021906 |
| KLK10 | kallikrein-related peptidase 10 | -0.0218041 |
| RUNX1 | runt-related transcription factor 1 | -0.021677 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0213679 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0213672 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0209937 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0208307 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -0.0207531 |
| RPS11 | ribosomal protein S11 | -0.0204946 |
| DIAPH2 | diaphanous-related formin 2 | -0.0204168 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0204097 |
| DST | dystonin | -0.0203349 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0203164 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0201039 |
| WASF2 | WAS protein family, member 2 | -0.0197291 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0197185 |
| S100A10 | S100 calcium binding protein A10 | -0.0196425 |
