RMC-6236_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description RMC-6236 perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the RMC-6236_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.110496
EEF2 eukaryotic translation elongation factor 2 0.0973602
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0788751
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0610414
LMO7 LIM domain 7 0.057944
FTH1 ferritin, heavy polypeptide 1 0.0504559
HSPA8 heat shock 70kDa protein 8 0.048234
PDE4B phosphodiesterase 4B, cAMP-specific 0.0394291
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0388836
SNX9 sorting nexin 9 0.0371178
NCEH1 neutral cholesterol ester hydrolase 1 0.0330005
CPOX coproporphyrinogen oxidase 0.0328094
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0318956
SRRM2 serine/arginine repetitive matrix 2 0.0313165
ARRDC3 arrestin domain containing 3 0.029234
SGMS2 sphingomyelin synthase 2 0.0290471
LOC102724023 ES1 protein homolog, mitochondrial 0.0287782
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0283969
USP9X ubiquitin specific peptidase 9, X-linked 0.0279247
LAMC2 laminin, gamma 2 0.0254556
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0254159
AHNAK AHNAK nucleoprotein 0.0253918
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0248904
CLDND1 claudin domain containing 1 0.0248606
PCBP2 poly(rC) binding protein 2 0.0247298
ANXA1 annexin A1 0.0245718
CTSB cathepsin B 0.0238473
FHL2 four and a half LIM domains 2 0.0236784
FAT1 FAT atypical cadherin 1 0.0235123
SLTM SAFB-like, transcription modulator 0.0230573
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0205724
TOP2B topoisomerase (DNA) II beta 180kDa 0.0203729
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0200148
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.019665
TSC22D2 TSC22 domain family, member 2 0.0187681
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0187439
RPS18 ribosomal protein S18 0.017944
RPL3 ribosomal protein L3 0.0178927
MYH9 myosin, heavy chain 9, non-muscle 0.0176234
ATXN1 ataxin 1 0.0176115
MACF1 microtubule-actin crosslinking factor 1 0.0170149
SON SON DNA binding protein 0.0167682
RPS7 ribosomal protein S7 0.016571
SERTAD2 SERTA domain containing 2 0.0162558
NFE2L2 nuclear factor, erythroid 2-like 2 0.0160612
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0160437
EGFR epidermal growth factor receptor 0.015959
OSBPL10 oxysterol binding protein-like 10 0.0157792
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0156762
AGTPBP1 ATP/GTP binding protein 1 0.0153902
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0151947
PDLIM5 PDZ and LIM domain 5 0.0150313
ARL15 ADP-ribosylation factor-like 15 0.01487
ZFP36 ZFP36 ring finger protein 0.0145829
FLNA filamin A, alpha 0.0145509
TES testin LIM domain protein 0.0145458
EIF4B eukaryotic translation initiation factor 4B 0.0143917
RPS2 ribosomal protein S2 0.0140956
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0138886
HOMER1 homer scaffolding protein 1 0.0138724
KIF5B kinesin family member 5B 0.0136595
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0135734
DSPP dentin sialophosphoprotein 0.0135488
SFTPA2 surfactant protein A2 0.0134742
TJP1 tight junction protein 1 0.0132727
MYO5B myosin VB 0.0132583
DOCK5 dedicator of cytokinesis 5 0.0127312
DPY19L1 dpy-19-like 1 (C. elegans) 0.012677
SMAD3 SMAD family member 3 0.0125668
ADGRA3 adhesion G protein-coupled receptor A3 0.0125182
GCLC glutamate-cysteine ligase, catalytic subunit 0.0124556
NTSR1 neurotensin receptor 1 (high affinity) 0.0124057
EVA1C eva-1 homolog C (C. elegans) 0.0123835
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0123126
KDM6B lysine (K)-specific demethylase 6B 0.0122813
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0121405
KLF6 Kruppel-like factor 6 0.0119876
TSC22D1 TSC22 domain family, member 1 0.011938
ARL5B ADP-ribosylation factor-like 5B 0.0118968
SF1 splicing factor 1 0.0118257
NDRG1 N-myc downstream regulated 1 0.0117668
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0114857
SYAP1 synapse associated protein 1 0.0113435
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 0.0112797
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0112718
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0112061
IGSF9B immunoglobulin superfamily, member 9B 0.0111511
MPZL3 myelin protein zero-like 3 0.0110778
YAP1 Yes-associated protein 1 0.0110224
RBM17 RNA binding motif protein 17 0.0109915
KDM1B lysine (K)-specific demethylase 1B 0.0109027
TXNIP thioredoxin interacting protein 0.0107481
SMIM3 small integral membrane protein 3 0.0106957
RPS3A ribosomal protein S3A 0.0105505
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0105382
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0105321
PRDM1 PR domain containing 1, with ZNF domain 0.0105056
BHLHE40 basic helix-loop-helix family, member e40 0.010491
TMF1 TATA element modulatory factor 1 0.0104508
ZEB1 zinc finger E-box binding homeobox 1 0.0103583

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.287987
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.219913
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.174597
ACTG1 actin gamma 1 -0.139187
IER3 immediate early response 3 -0.124043
TMSB10 thymosin beta 10 -0.109615
RPS6 ribosomal protein S6 -0.108861
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0958905
RPL35A ribosomal protein L35a -0.0896418
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0874243
TPT1 tumor protein, translationally-controlled 1 -0.0856725
CD36 CD36 molecule (thrombospondin receptor) -0.0783068
RPS24 ribosomal protein S24 -0.0777753
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0764482
RPS29 ribosomal protein S29 -0.0740806
RPS8 ribosomal protein S8 -0.0726853
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0719714
RPLP1 ribosomal protein, large, P1 -0.069277
RPL34 ribosomal protein L34 -0.0659175
RAD51B RAD51 paralog B -0.0656381
FERMT1 fermitin family member 1 -0.0622943
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.059991
RPL23 ribosomal protein L23 -0.0592125
RPS25 ribosomal protein S25 -0.0589419
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0566824
RPS19 ribosomal protein S19 -0.0543285
RPLP2 ribosomal protein, large, P2 -0.0535561
RPL31 ribosomal protein L31 -0.0530518
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0521842
RPS23 ribosomal protein S23 -0.0517814
RPS13 ribosomal protein S13 -0.0514047
RPL37A ribosomal protein L37a -0.0513667
SERINC5 serine incorporator 5 -0.0482883
CUX1 cut-like homeobox 1 -0.0449976
S100A10 S100 calcium binding protein A10 -0.0443511
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0442496
EGR1 early growth response 1 -0.0439266
RPL8 ribosomal protein L8 -0.0426342
S100A6 S100 calcium binding protein A6 -0.0421971
CD9 CD9 molecule -0.0412582
RPL12 ribosomal protein L12 -0.0403794
RPLP0 ribosomal protein, large, P0 -0.0403711
FNDC3B fibronectin type III domain containing 3B -0.0400262
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0400198
RPL32 ribosomal protein L32 -0.0398363
ACTN4 actinin, alpha 4 -0.0398072
RPL5 ribosomal protein L5 -0.0394711
RPL9 ribosomal protein L9 -0.0381887
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0381344
HLA-B major histocompatibility complex, class I, B -0.0380656
FTL ferritin, light polypeptide -0.0380611
OXR1 oxidation resistance 1 -0.0379269
ITPKC inositol-trisphosphate 3-kinase C -0.0376275
SETD5 SET domain containing 5 -0.0376255
RPS21 ribosomal protein S21 -0.0372869
FHIT fragile histidine triad -0.0372835
RPS11 ribosomal protein S11 -0.0368393
COG5 component of oligomeric golgi complex 5 -0.0365495
RPS15 ribosomal protein S15 -0.0364076
RPL27A ribosomal protein L27a -0.035931
RPL38 ribosomal protein L38 -0.0359167
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.035389
GDF15 growth differentiation factor 15 -0.0353432
RPS5 ribosomal protein S5 -0.0352679
RPS27A ribosomal protein S27a -0.0341058
RPL19 ribosomal protein L19 -0.0340537
RPL7A ribosomal protein L7a -0.0338949
RPS10 ribosomal protein S10 -0.033688
RPS14 ribosomal protein S14 -0.0336754
RPL28 ribosomal protein L28 -0.0332562
RPL15 ribosomal protein L15 -0.0331863
PKM pyruvate kinase, muscle -0.0321998
BAMBI BMP and activin membrane-bound inhibitor -0.0319911
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0312089
RPS16 ribosomal protein S16 -0.0310684
RPL13A ribosomal protein L13a -0.0309307
ZNRF3 zinc and ring finger 3 -0.0309084
IARS1 isoleucyl-tRNA synthetase 1 -0.030518
VCL vinculin -0.0303332
KPNB1 karyopherin (importin) beta 1 -0.0299715
RPS17 ribosomal protein S17 -0.0298944
ANXA2 annexin A2 -0.0295451
NF1 neurofibromin 1 -0.028925
DEK DEK proto-oncogene -0.0285377
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0282392
TAS2R14 taste receptor, type 2, member 14 -0.0281165
KLF3 Kruppel-like factor 3 (basic) -0.027588
RPL36A ribosomal protein L36a -0.0272034
GPHN gephyrin -0.0270744
VIM vimentin -0.0269646
KRT18 keratin 18, type I -0.0266681
RPL11 ribosomal protein L11 -0.025992
HLA-A major histocompatibility complex, class I, A -0.0258287
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.02571
RPL7 ribosomal protein L7 -0.0257063
IGFBP3 insulin-like growth factor binding protein 3 -0.0255574
GLG1 golgi glycoprotein 1 -0.02535
OSBPL3 oxysterol binding protein-like 3 -0.0253431
RPS28 ribosomal protein S28 -0.0252443
MAP4 microtubule-associated protein 4 -0.0252058