RMC-6236_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description RMC-6236 perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the RMC-6236_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.231268
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.137517
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0789588
DSPP dentin sialophosphoprotein 0.0694403
RPS12 ribosomal protein S12 0.0687554
RPS8 ribosomal protein S8 0.0605028
FTH1 ferritin, heavy polypeptide 1 0.0600155
RPL26 ribosomal protein L26 0.0599846
EEF2 eukaryotic translation elongation factor 2 0.0593781
RPL37A ribosomal protein L37a 0.047793
WWOX WW domain containing oxidoreductase 0.0474506
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0449433
RPL35A ribosomal protein L35a 0.0435396
RPS2 ribosomal protein S2 0.0432512
RPL23 ribosomal protein L23 0.0422711
RPS6 ribosomal protein S6 0.0403535
HSPA8 heat shock 70kDa protein 8 0.0403145
RPS17 ribosomal protein S17 0.0396322
PCBP2 poly(rC) binding protein 2 0.0383106
RPL12 ribosomal protein L12 0.0378474
SERINC5 serine incorporator 5 0.03704
LOC102724023 ES1 protein homolog, mitochondrial 0.0368099
RPS3 ribosomal protein S3 0.0356975
RPS19 ribosomal protein S19 0.0313743
PCDH9 protocadherin 9 0.0309726
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0294834
RACK1 receptor for activated C kinase 1 0.0289393
SET SET nuclear proto-oncogene 0.0286777
TPT1 tumor protein, translationally-controlled 1 0.0281523
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0278267
TNS3 tensin 3 0.0274951
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0267813
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0260648
CTSB cathepsin B 0.0252375
SAMD4A sterile alpha motif domain containing 4A 0.0251282
YBX1 Y box binding protein 1 0.023461
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0232024
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.022269
RPL9 ribosomal protein L9 0.0222483
HSPH1 heat shock 105kDa/110kDa protein 1 0.0221307
CD44 CD44 molecule (Indian blood group) 0.0218806
MT2A metallothionein 2A 0.0217476
MPG N-methylpurine-DNA glycosylase 0.0217218
RPS7 ribosomal protein S7 0.0214777
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0213674
RPS4X ribosomal protein S4, X-linked 0.0212664
EGFR epidermal growth factor receptor 0.0205032
VIM vimentin 0.0198701
RPL27 ribosomal protein L27 0.019392
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0190573
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0189523
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0189312
B2M beta-2-microglobulin 0.0188681
SOX5 SRY (sex determining region Y)-box 5 0.0187369
SRRM2 serine/arginine repetitive matrix 2 0.0185313
NACA nascent polypeptide-associated complex alpha subunit 0.0185056
RPL7 ribosomal protein L7 0.0184727
RPLP1 ribosomal protein, large, P1 0.0183677
EZR ezrin 0.0183617
AHRR aryl-hydrocarbon receptor repressor 0.018316
STK38L serine/threonine kinase 38 like 0.0182495
RPL3 ribosomal protein L3 0.0181611
FTL ferritin, light polypeptide 0.0180484
EMP1 epithelial membrane protein 1 0.0178818
SMAD3 SMAD family member 3 0.0175463
EPHB2 EPH receptor B2 0.0173513
MYADM myeloid-associated differentiation marker 0.0173392
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0167533
RPS14 ribosomal protein S14 0.0167515
RPL35 ribosomal protein L35 0.0166947
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0166025
SVIL supervillin 0.0165206
SON SON DNA binding protein 0.0164931
IRS2 insulin receptor substrate 2 0.016448
LGALS3 lectin, galactoside-binding, soluble, 3 0.0162695
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0160504
RPL31 ribosomal protein L31 0.0160504
SOX9 SRY (sex determining region Y)-box 9 0.0160418
NOTUM notum pectinacetylesterase homolog (Drosophila) 0.0157766
BMP5 bone morphogenetic protein 5 0.0156578
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0154382
RPL36 ribosomal protein L36 0.0153631
EIF5 eukaryotic translation initiation factor 5 0.0153359
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0149491
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0147534
SMC1A structural maintenance of chromosomes 1A 0.0142766
BICC1 BicC family RNA binding protein 1 0.0138126
ARHGAP18 Rho GTPase activating protein 18 0.0138046
RPS3A ribosomal protein S3A 0.0137117
RPL21 ribosomal protein L21 0.013539
AXIN2 axin 2 0.0133455
CLSTN2 calsyntenin 2 0.0133411
EEF1G eukaryotic translation elongation factor 1 gamma 0.0133154
APLP2 amyloid beta (A4) precursor-like protein 2 0.0132942
MSN moesin 0.0131437
RBP1 retinol binding protein 1, cellular 0.0129012
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0128626
KLF6 Kruppel-like factor 6 0.0128173
NPAS3 neuronal PAS domain protein 3 0.0128024
AFF1 AF4/FMR2 family, member 1 0.012622

decreased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) -0.155241
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.115707
CDH13 cadherin 13 -0.101531
MAML2 mastermind-like 2 (Drosophila) -0.0994187
NAV2 neuron navigator 2 -0.0946366
PDE4D phosphodiesterase 4D, cAMP-specific -0.0892364
KRT18 keratin 18, type I -0.0816876
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0804544
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0756707
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0686989
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0677718
AKAP12 A kinase (PRKA) anchor protein 12 -0.0651987
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0643611
IARS1 isoleucyl-tRNA synthetase 1 -0.0639443
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0620193
DST dystonin -0.0613078
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0612096
KRT8 keratin 8, type II -0.060618
BIRC6 baculoviral IAP repeat containing 6 -0.0602235
TMSB10 thymosin beta 10 -0.0586817
RUNX1 runt-related transcription factor 1 -0.0582473
PROX1 prospero homeobox 1 -0.0569459
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0567227
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.056057
GLG1 golgi glycoprotein 1 -0.0550929
ANKRD10 ankyrin repeat domain 10 -0.0533661
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0527133
PGK1 phosphoglycerate kinase 1 -0.0525235
GMDS GDP-mannose 4,6-dehydratase -0.0518033
SYT1 synaptotagmin I -0.0511575
THOC2 THO complex 2 -0.0508977
USP34 ubiquitin specific peptidase 34 -0.0505773
BCL2L1 BCL2-like 1 -0.0502628
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0501873
DLG1 discs, large homolog 1 (Drosophila) -0.0497056
ZMYND8 zinc finger, MYND-type containing 8 -0.0496834
NF1 neurofibromin 1 -0.0486788
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.046569
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0457996
SLC38A2 solute carrier family 38, member 2 -0.0457423
OSBPL3 oxysterol binding protein-like 3 -0.0456611
KPNB1 karyopherin (importin) beta 1 -0.0453706
TMEM123 transmembrane protein 123 -0.0447294
TAS2R14 taste receptor, type 2, member 14 -0.044132
ANLN anillin, actin binding protein -0.0440516
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0436548
FLNB filamin B, beta -0.0436187
FNDC3A fibronectin type III domain containing 3A -0.0428629
ACTG1 actin gamma 1 -0.0428283
ZFAND3 zinc finger, AN1-type domain 3 -0.0423414
ITGA6 integrin, alpha 6 -0.0419626
GARS1 glycyl-tRNA synthetase 1 -0.0409699
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.040793
NCOR1 nuclear receptor corepressor 1 -0.0404807
CCND1 cyclin D1 -0.0400082
ITGB4 integrin, beta 4 -0.0396772
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.039581
SKAP1 src kinase associated phosphoprotein 1 -0.038117
RBM39 RNA binding motif protein 39 -0.0379073
HDAC4 histone deacetylase 4 -0.0375288
ZMYM2 zinc finger, MYM-type 2 -0.0373194
TMEM41B transmembrane protein 41B -0.0372895
TPM4 tropomyosin 4 -0.0367095
OXR1 oxidation resistance 1 -0.0364871
TMCC1 transmembrane and coiled-coil domain family 1 -0.0363936
ITPRID2 ITPR interacting domain containing 2 -0.03599
MON2 MON2 homolog (S. cerevisiae) -0.0358643
JMJD1C jumonji domain containing 1C -0.0358298
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0357895
DIAPH3 diaphanous-related formin 3 -0.0357365
KIZ kizuna centrosomal protein -0.0356561
VMP1 vacuole membrane protein 1 -0.0356053
PIBF1 progesterone immunomodulatory binding factor 1 -0.035524
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0354384
CANX calnexin -0.0354082
EPB41 erythrocyte membrane protein band 4.1 -0.0352854
WDFY2 WD repeat and FYVE domain containing 2 -0.0345316
CDK6 cyclin-dependent kinase 6 -0.0344476
COG5 component of oligomeric golgi complex 5 -0.0344393
MED13 mediator complex subunit 13 -0.0341049
TNIK TRAF2 and NCK interacting kinase -0.033977
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0339499
ANKRD17 ankyrin repeat domain 17 -0.0339349
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0338846
CEP95 centrosomal protein 95kDa -0.0338234
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0336908
BRWD3 bromodomain and WD repeat domain containing 3 -0.0335487
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -0.0329476
APP amyloid beta (A4) precursor protein -0.0328456
MORF4L2 mortality factor 4 like 2 -0.0328411
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0325745
TMEM163 transmembrane protein 163 -0.0324081
FRMD5 FERM domain containing 5 -0.0321437
ATXN1 ataxin 1 -0.0319737
ZBTB20 zinc finger and BTB domain containing 20 -0.0319515
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0319309
RAB6A RAB6A, member RAS oncogene family -0.031469
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0309702
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0307277
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0305868