RMC-6236_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description RMC-6236 perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the RMC-6236_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.130175
FTH1 ferritin, heavy polypeptide 1 0.126141
B2M beta-2-microglobulin 0.106134
ALCAM activated leukocyte cell adhesion molecule 0.0731891
MT2A metallothionein 2A 0.068654
CD44 CD44 molecule (Indian blood group) 0.0683787
EEF2 eukaryotic translation elongation factor 2 0.0617336
FBN1 fibrillin 1 0.0610595
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0594263
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0583255
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0578834
FN1 fibronectin 1 0.0574913
EIF1 eukaryotic translation initiation factor 1 0.0549423
SAMD4A sterile alpha motif domain containing 4A 0.0544724
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.053394
MYH9 myosin, heavy chain 9, non-muscle 0.0484728
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0471927
TRIO trio Rho guanine nucleotide exchange factor 0.0469497
LDHA lactate dehydrogenase A 0.0460993
DST dystonin 0.0450617
FTL ferritin, light polypeptide 0.0445656
HLA-B major histocompatibility complex, class I, B 0.0444873
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0442427
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0441696
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0417687
NDRG1 N-myc downstream regulated 1 0.0415303
TMSB4X thymosin beta 4, X-linked 0.0414391
VEGFA vascular endothelial growth factor A 0.0405656
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0391631
AKAP12 A kinase (PRKA) anchor protein 12 0.038467
SFTPA2 surfactant protein A2 0.0373611
COL1A2 collagen, type I, alpha 2 0.0359403
PCBP2 poly(rC) binding protein 2 0.0318841
HIPK2 homeodomain interacting protein kinase 2 0.0318707
IGFBP7 insulin-like growth factor binding protein 7 0.0318524
RPS12 ribosomal protein S12 0.0314364
ADM adrenomedullin 0.0303646
RHOA ras homolog family member A 0.0300861
ENO1 enolase 1, (alpha) 0.0295795
MAP1B microtubule-associated protein 1B 0.0295414
CTSB cathepsin B 0.0294077
CCDC80 coiled-coil domain containing 80 0.0290908
ZFP36L1 ZFP36 ring finger protein-like 1 0.0284233
SRRM2 serine/arginine repetitive matrix 2 0.0273206
CALR calreticulin 0.0272998
PTMA prothymosin, alpha 0.0272389
NFE2L1 nuclear factor, erythroid 2-like 1 0.0271228
PALLD palladin, cytoskeletal associated protein 0.0267912
RPS3 ribosomal protein S3 0.0266559
KTN1 kinectin 1 (kinesin receptor) 0.0263341
RPS8 ribosomal protein S8 0.0262785
DSPP dentin sialophosphoprotein 0.0257276
TMSB10 thymosin beta 10 0.025663
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0255295
TPI1 triosephosphate isomerase 1 0.0254054
HDAC9 histone deacetylase 9 0.024265
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0240413
TIMP1 TIMP metallopeptidase inhibitor 1 0.0240408
RACK1 receptor for activated C kinase 1 0.0237717
SPAG9 sperm associated antigen 9 0.0236727
HLA-A major histocompatibility complex, class I, A 0.0235585
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0234122
FMNL2 formin-like 2 0.0234085
RPL12 ribosomal protein L12 0.0225615
RPS6 ribosomal protein S6 0.0218629
OPTN optineurin 0.021789
SOD2 superoxide dismutase 2, mitochondrial 0.0214989
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0213119
RPL37A ribosomal protein L37a 0.0212413
LOX lysyl oxidase 0.0212167
MMP2 matrix metallopeptidase 2 0.0211541
LGALS1 lectin, galactoside-binding, soluble, 1 0.0210971
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0210409
RHOB ras homolog family member B 0.0208361
SPTBN1 spectrin, beta, non-erythrocytic 1 0.020135
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0201151
ATF4 activating transcription factor 4 0.0197653
MSN moesin 0.0197613
TGFBI transforming growth factor, beta-induced, 68kDa 0.0197348
MYOF myoferlin 0.0193165
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.0193055
CSDE1 cold shock domain containing E1, RNA-binding 0.0192475
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0188559
DSTN destrin (actin depolymerizing factor) 0.0187533
ARRDC3 arrestin domain containing 3 0.0186783
ZBTB20 zinc finger and BTB domain containing 20 0.0186561
HLA-E major histocompatibility complex, class I, E 0.0185486
SET SET nuclear proto-oncogene 0.017971
RPL9 ribosomal protein L9 0.0178018
TIMP2 TIMP metallopeptidase inhibitor 2 0.0177934
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0175218
ENO2 enolase 2 (gamma, neuronal) 0.0174331
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0170589
RPL26 ribosomal protein L26 0.0170445
LOC102724023 ES1 protein homolog, mitochondrial 0.0168565
ANXA2 annexin A2 0.0167863
CANX calnexin 0.0165243
RPS17 ribosomal protein S17 0.0164343
JUN jun proto-oncogene 0.0163308
TIMP3 TIMP metallopeptidase inhibitor 3 0.0162183

decreased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 -0.274197
NALF1 NALCN channel auxiliary factor 1 -0.214958
HMGA2 high mobility group AT-hook 2 -0.172866
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.134009
MMP1 matrix metallopeptidase 1 -0.127086
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.125219
MYO10 myosin X -0.119733
OXR1 oxidation resistance 1 -0.114323
PRKG1 protein kinase, cGMP-dependent, type I -0.111764
COL6A2 collagen, type VI, alpha 2 -0.103347
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.102514
ADGRB3 adhesion G protein-coupled receptor B3 -0.102174
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0985219
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0826583
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0816828
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.080606
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0793904
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0734715
ASPH aspartate beta-hydroxylase -0.0726285
ATP13A3 ATPase type 13A3 -0.070498
CDH13 cadherin 13 -0.0660788
COL6A1 collagen, type VI, alpha 1 -0.065382
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0612163
FRMD4A FERM domain containing 4A -0.060831
ZEB1 zinc finger E-box binding homeobox 1 -0.0546435
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0535458
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0529626
GLIS3 GLIS family zinc finger 3 -0.0526153
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0514166
EGFR epidermal growth factor receptor -0.049694
PDE8A phosphodiesterase 8A -0.0468478
EMP1 epithelial membrane protein 1 -0.0454963
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0453495
KIAA1549L KIAA1549-like -0.0446017
NAV1 neuron navigator 1 -0.0445769
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0436658
RAI14 retinoic acid induced 14 -0.0436102
PDE4D phosphodiesterase 4D, cAMP-specific -0.0417442
ARHGAP24 Rho GTPase activating protein 24 -0.0416354
SASH1 SAM and SH3 domain containing 1 -0.041364
DIAPH2 diaphanous-related formin 2 -0.0406634
AFF3 AF4/FMR2 family, member 3 -0.0406419
ABI3BP ABI family, member 3 (NESH) binding protein -0.0379125
WNT5A wingless-type MMTV integration site family, member 5A -0.0378786
ANTXR2 anthrax toxin receptor 2 -0.0377195
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0374529
MMP12 matrix metallopeptidase 12 -0.036577
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0355946
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0353896
CCDC102B coiled-coil domain containing 102B -0.0346019
VMP1 vacuole membrane protein 1 -0.0341818
SAMD3 sterile alpha motif domain containing 3 -0.0338347
FNDC3B fibronectin type III domain containing 3B -0.0336175
MAML3 mastermind-like 3 (Drosophila) -0.0325911
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0325839
PRRX1 paired related homeobox 1 -0.0320974
TMEM165 transmembrane protein 165 -0.0316417
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0315549
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0301439
SEC24D SEC24 family member D -0.0298329
SEPTIN11 septin 11 -0.0292058
COL5A3 collagen, type V, alpha 3 -0.0288386
SEC31A SEC31 homolog A (S. cerevisiae) -0.0284181
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0281825
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0279982
EGR1 early growth response 1 -0.0270053
ITGA1 integrin, alpha 1 -0.0269195
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0266245
LTBP1 latent transforming growth factor beta binding protein 1 -0.026554
ELL2 elongation factor, RNA polymerase II, 2 -0.0258273
CLTC clathrin, heavy chain (Hc) -0.0257927
FNDC3A fibronectin type III domain containing 3A -0.0257503
MON2 MON2 homolog (S. cerevisiae) -0.0257274
NCKAP5 NCK-associated protein 5 -0.0254279
DDR2 discoidin domain receptor tyrosine kinase 2 -0.0253481
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0244288
LOXL2 lysyl oxidase-like 2 -0.0243529
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0243236
MCL1 myeloid cell leukemia 1 -0.0243173
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0241612
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0241579
PDGFRB platelet-derived growth factor receptor, beta polypeptide -0.0240543
RAB1A RAB1A, member RAS oncogene family -0.0239608
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0239344
CLIP2 CAP-GLY domain containing linker protein 2 -0.023866
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0234228
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0232857
VCL vinculin -0.0230919
PRR16 proline rich 16 -0.023083
DNER delta/notch-like EGF repeat containing -0.0227301
TMEM263 transmembrane protein 263 -0.0227074
TSHZ3 teashirt zinc finger homeobox 3 -0.0226512
PRSS23 protease, serine, 23 -0.0226117
TFPI2 tissue factor pathway inhibitor 2 -0.0225408
NF1 neurofibromin 1 -0.0221876
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -0.0221061
GLG1 golgi glycoprotein 1 -0.0219713
OSMR oncostatin M receptor -0.021928
EFCAB13 EF-hand calcium binding domain 13 -0.0218754
DLC1 DLC1 Rho GTPase activating protein -0.0215987