RNA degradation Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex. (Kyoto Encyclopedia of Genes and Genomes, hsa03018)
External Link https://www.kegg.jp/entry/hsa03018
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Genes

78 proteins participating in the RNA degradation pathway from the KEGG Pathways 2026 dataset.

Symbol Name
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
BTG4 B-cell translocation gene 4
C1D C1D nuclear receptor corepressor
CNOT1 CCR4-NOT transcription complex, subunit 1
CNOT10 CCR4-NOT transcription complex, subunit 10
CNOT2 CCR4-NOT transcription complex, subunit 2
CNOT3 CCR4-NOT transcription complex, subunit 3
CNOT4 CCR4-NOT transcription complex, subunit 4
CNOT6 CCR4-NOT transcription complex, subunit 6
CNOT6L CCR4-NOT transcription complex, subunit 6-like
CNOT7 CCR4-NOT transcription complex, subunit 7
CNOT8 CCR4-NOT transcription complex, subunit 8
CNOT9 CCR4-NOT transcription complex subunit 9
DCP1A decapping mRNA 1A
DCP1B decapping mRNA 1B
DCP2 decapping mRNA 2
DCPS decapping enzyme, scavenger
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DIS3L DIS3 like exosome 3'-5' exoribonuclease
EDC3 enhancer of mRNA decapping 3
EDC4 enhancer of mRNA decapping 4
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
ENO3 enolase 3 (beta, muscle)
EXOSC1 exosome component 1
EXOSC10 exosome component 10
EXOSC2 exosome component 2
EXOSC3 exosome component 3
EXOSC4 exosome component 4
EXOSC5 exosome component 5
EXOSC6 exosome component 6
EXOSC7 exosome component 7
EXOSC8 exosome component 8
EXOSC9 exosome component 9
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
LSM1 LSM1, U6 small nuclear RNA associated
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MPHOSPH6 M-phase phosphoprotein 6
MTREX Mtr4 exosome RNA helicase
NLRP4 NLR family, pyrin domain containing 4
NUDT16 nudix (nucleoside diphosphate linked moiety X)-type motif 16
PABPC1 poly(A) binding protein, cytoplasmic 1
PABPC1L poly(A) binding protein, cytoplasmic 1-like
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B
PABPC3 poly(A) binding protein, cytoplasmic 3
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PABPC4L poly(A) binding protein, cytoplasmic 4-like
PABPC5 poly(A) binding protein, cytoplasmic 5
PAN3 PAN3 poly(A) specific ribonuclease subunit
PARN poly(A)-specific ribonuclease
PATL1 protein associated with topoisomerase II homolog 1 (yeast)
PFKL phosphofructokinase, liver
PFKM phosphofructokinase, muscle
PFKP phosphofructokinase, platelet
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1
PNPT1 polyribonucleotide nucleotidyltransferase 1
SKIC2 SKI2 subunit of superkiller complex
SKIC3 SKI3 subunit of superkiller complex
SKIC8 SKI8 subunit of superkiller complex
TENT4A terminal nucleotidyltransferase 4A
TENT4B terminal nucleotidyltransferase 4B
TOB1 transducer of ERBB2, 1
TOB2 transducer of ERBB2, 2
XRN1 5'-3' exoribonuclease 1
XRN2 5'-3' exoribonuclease 2
ZCCHC7 zinc finger, CCHC domain containing 7