RND2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description Rho family GTPase 2|This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8153)
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Genes

342 genes differentially expressed following the RND2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ZNF436 zinc finger protein 436 2.41517
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.41517
CABP4 calcium binding protein 4 2.41517
PCDHB6 protocadherin beta 6 2.41517
GRXCR2 glutaredoxin, cysteine rich 2 2.41517
EPB42 erythrocyte membrane protein band 4.2 2.41517
PROB1 proline-rich basic protein 1 2.41517
AADACL3 arylacetamide deacetylase-like 3 2.41517
PAX8 paired box 8 2.41517
TUBB8 tubulin, beta 8 class VIII 2.41517
ADGRE3 adhesion G protein-coupled receptor E3 2.41517
CDH5 cadherin 5, type 2 (vascular endothelium) 2.41517
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 2.41517
FAM3D family with sequence similarity 3, member D 2.41517
TBX21 T-box 21 2.41517
SLC22A14 solute carrier family 22, member 14 2.41517
ACR acrosin 2.41517
BAD BCL2-associated agonist of cell death 2.41517
TAS2R5 taste receptor, type 2, member 5 2.41517
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.41517
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.41517
COL20A1 collagen, type XX, alpha 1 2.41517
SLC30A2 solute carrier family 30 (zinc transporter), member 2 2.41517
MUSK muscle, skeletal, receptor tyrosine kinase 2.41517
TRIM77 tripartite motif containing 77 2.41517
CSNK2A3 casein kinase 2, alpha 3 polypeptide 2.41517
TPPP tubulin polymerization promoting protein 2.41517
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.41517
LVRN laeverin 2.41517
HIC1 hypermethylated in cancer 1 2.41517
LHX1 LIM homeobox 1 2.41517
PCDHGA11 protocadherin gamma subfamily A, 11 2.41517
BTBD19 BTB (POZ) domain containing 19 2.41517
ZC2HC1B zinc finger, C2HC-type containing 1B 2.41517
BFSP2 beaded filament structural protein 2, phakinin 2.41517
MUC22 mucin 22 2.41517
GPR101 G protein-coupled receptor 101 2.41517
C11ORF87 chromosome 11 open reading frame 87 2.41517
PTGFR prostaglandin F receptor (FP) 2.41517
C2ORF80 chromosome 2 open reading frame 80 2.41517
LCN15 lipocalin 15 2.41517
UBA7 ubiquitin-like modifier activating enzyme 7 2.41517
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.41517
PRSS36 protease, serine, 36 2.41517
SPATA22 spermatogenesis associated 22 2.41517
S100A1 S100 calcium binding protein A1 2.41517
LKAAEAR1 LKAAEAR motif containing 1 2.41517
FAM90A11 family with sequence similarity 90 member A11 2.41517
NDUFAF8 NADH:ubiquinone oxidoreductase complex assembly factor 8 2.41517
FREY1 Frey regulator of sperm-oocyte fusion 1 2.41517
CCDC198 coiled-coil domain containing 198 2.41517
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.41517
C3AR1 complement component 3a receptor 1 2.41517
YIPF7 Yip1 domain family, member 7 2.41517
BZW1 basic leucine zipper and W2 domains 1 2.41517
SRGN serglycin 2.41517
ADRB1 adrenoceptor beta 1 2.41517
GARIN1A golgi associated RAB2 interactor 1A 2.41517
CLEC20A C-type lectin domain containing 20A 2.41517
GLYATL1B glycine-N-acyltransferase like 1B 2.41517
DRC5 dynein regulatory complex subunit 5 2.41517
SPATA31H1 SPATA31 subfamily H member 1 2.41517
WASL-DT WASL divergent transcript 2.41517
NOTCH2NLB notch 2 N-terminal like B 2.41517
C1ORF232 chromosome 1 open reading frame 230 2.41517
ZNF593OS ZNF593 opposite strand 2.41517
CALHM4 calcium homeostasis modulator family member 4 2.41517
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 2.41517
MYMK myomaker, myoblast fusion factor 2.41517
FCMR Fc fragment of IgM receptor 2.41517
TBX10 T-box 10 2.41517
SYT15 synaptotagmin XV 2.41517
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.41517
TLR8 toll-like receptor 8 2.41517
SCRT1 scratch family zinc finger 1 2.41517
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.41517
MSX2 msh homeobox 2 2.41517
ACTA1 actin, alpha 1, skeletal muscle 2.41517
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.41517
TMIE transmembrane inner ear 2.41517
GGT6 gamma-glutamyltransferase 6 2.41517
TBX5 T-box 5 2.41517
CDSN corneodesmosin 2.41517
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.41517
CNGA3 cyclic nucleotide gated channel alpha 3 2.41517
PNPLA1 patatin-like phospholipase domain containing 1 2.41517
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.41517
PGRMC1 progesterone receptor membrane component 1 2.41517
C9 complement component 9 2.41517
TACR2 tachykinin receptor 2 2.41517
SBSN suprabasin 2.41517
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2.41517
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.41517
KLHL33 kelch-like family member 33 2.41517
PASD1 PAS domain containing 1 2.41517
RAP1A RAP1A, member of RAS oncogene family 2.41517
CTBP1 C-terminal binding protein 1 2.41517
ACADSB acyl-CoA dehydrogenase, short/branched chain 2.41517
RPS23 ribosomal protein S23 2.41517
PCDHGA4 protocadherin gamma subfamily A, 4 2.41517
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.41517
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.41517
ISL1 ISL LIM homeobox 1 2.41517
IL1A interleukin 1, alpha 2.41517
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.41517
EMILIN1 elastin microfibril interfacer 1 2.41517
SERINC4 serine incorporator 4 2.41517
DEFB4A defensin, beta 4A 2.41517
CNTF ciliary neurotrophic factor 2.41517
PLRG1 pleiotropic regulator 1 2.41517
RGS13 regulator of G-protein signaling 13 2.41517
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.41517
OPRK1 opioid receptor, kappa 1 2.41517
POF1B premature ovarian failure, 1B 2.41517
AQP9 aquaporin 9 2.41517
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.41517
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.41517
BPIFB1 BPI fold containing family B, member 1 2.41517
RNF128 ring finger protein 128, E3 ubiquitin protein ligase 2.41517
C8ORF89 chromosome 8 open reading frame 89 2.41517
ESPNL espin-like 2.41517
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.41517
HPGDS hematopoietic prostaglandin D synthase 2.41517
ETV3L ets variant 3-like 2.41517
WNT2 wingless-type MMTV integration site family member 2 2.41517
CLEC18A C-type lectin domain family 18, member A 2.41517
NPY2R neuropeptide Y receptor Y2 2.41517
MB myoglobin 2.41517
UPK1B uroplakin 1B 2.41517
SIDT1 SID1 transmembrane family, member 1 2.41517
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.41517
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 2.41517
KIAA1210 KIAA1210 2.41517
TBX1 T-box 1 2.41517
SPEF1 sperm flagellar 1 2.41517
RAD54L RAD54-like (S. cerevisiae) 2.41517
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.41517
TPPP3 tubulin polymerization-promoting protein family member 3 2.41517
GPR61 G protein-coupled receptor 61 2.41517
BCL2L15 BCL2-like 15 2.41517
MOS v-mos Moloney murine sarcoma viral oncogene homolog 2.41517
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.41517
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.41517
NPPA natriuretic peptide A 2.41517
MT1X metallothionein 1X 2.41517
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 2.41517
ACSM1 acyl-CoA synthetase medium-chain family member 1 2.41517
ACSM4 acyl-CoA synthetase medium-chain family member 4 2.41517
CIB3 calcium and integrin binding family member 3 2.41517
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.41517
LAMP5 lysosomal-associated membrane protein family, member 5 2.41517
SLC7A4 solute carrier family 7, member 4 2.41517
NTSR2 neurotensin receptor 2 2.41517
WDFY4 WDFY family member 4 2.41517
GCM2 glial cells missing homolog 2 (Drosophila) 2.41517
GPBAR1 G protein-coupled bile acid receptor 1 2.41517
C5AR2 complement component 5a receptor 2 2.41517
FOXP3 forkhead box P3 2.41517
ST18 suppression of tumorigenicity 18, zinc finger 2.41517
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.41517
ICA1L islet cell autoantigen 1,69kDa-like 2.41517
APOF apolipoprotein F 2.41517
BANF2 barrier to autointegration factor 2 2.41517
IL17D interleukin 17D 2.41517
POPDC2 popeye domain containing 2 2.41517
LHB luteinizing hormone beta polypeptide 2.41517
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 2.41517
OR10G8 olfactory receptor, family 10, subfamily G, member 8 2.41517
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 2.41517
KIF19 kinesin family member 19 2.41517
CSPG4 chondroitin sulfate proteoglycan 4 2.41517
FABP5 fatty acid binding protein 5 (psoriasis-associated) 2.40102
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.38492
CLDN23 claudin 23 2.38492
IL10RA interleukin 10 receptor, alpha 2.38492
FOXN4 forkhead box N4 2.38492
FAM193A family with sequence similarity 193, member A 2.38492
TMEM233 transmembrane protein 233 2.38492
MAP2K1 mitogen-activated protein kinase kinase 1 2.38492
FOSL1 FOS-like antigen 1 2.38492
TSPAN16 tetraspanin 16 2.38492
UTS2R urotensin 2 receptor 2.37646
PLA2G2C phospholipase A2, group IIC 2.37646
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 2.36485
CCDC86 coiled-coil domain containing 86 2.36485
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 2.34271
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like 2.33481
ZNF682 zinc finger protein 682 2.33277
SERBP1 SERPINE1 mRNA binding protein 1 2.331
THAP6 THAP domain containing 6 2.331
FLAD1 flavin adenine dinucleotide synthetase 1 2.32692
ZNF234 zinc finger protein 234 2.31817
MRPL1 mitochondrial ribosomal protein L1 2.31581
RPS13 ribosomal protein S13 2.30639
XDH xanthine dehydrogenase 2.30034
DPP7 dipeptidyl-peptidase 7 2.26309
TMTC2 transmembrane and tetratricopeptide repeat containing 2 2.24785
UBE2T ubiquitin-conjugating enzyme E2T 2.19384
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 2.19384
ATF6B activating transcription factor 6 beta 2.18451
TRIQK triple QxxK/R motif containing 2.17497
ZNF670 zinc finger protein 670 2.17489
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa 2.15844
PRR12 proline rich 12 2.15844
VAMP4 vesicle-associated membrane protein 4 2.15122
PFDN4 prefoldin subunit 4 2.15112
CRYZ crystallin, zeta (quinone reductase) 2.14195
GTPBP4 GTP binding protein 4 2.12985
SCAPER S-phase cyclin A-associated protein in the ER 2.12135
NIPAL2 NIPA-like domain containing 2 2.10169
GPR156 G protein-coupled receptor 156 2.08888
MYNN myoneurin 2.08756
THAP4 THAP domain containing 4 2.08662
NACA nascent polypeptide-associated complex alpha subunit 2.08662
TMEM258 transmembrane protein 258 2.0777
PPP4C protein phosphatase 4, catalytic subunit 2.07141
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 2.05559
STX10 syntaxin 10 2.02163
SRSF6 serine/arginine-rich splicing factor 6 2.01243
GRK7 G protein-coupled receptor kinase 7 2.00816
RPL12 ribosomal protein L12 2.00816
FSD2 fibronectin type III and SPRY domain containing 2 2.00816
ERH enhancer of rudimentary homolog (Drosophila) 2.00502

decreased expression

Symbol Name Standardized Value
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -2.41517
ATAD3A ATPase family, AAA domain containing 3A -2.41517
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 -2.41517
ULK1 unc-51 like autophagy activating kinase 1 -2.41517
COPG2 coatomer protein complex, subunit gamma 2 -2.41517
MEX3B mex-3 RNA binding family member B -2.41517
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 -2.41517
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 -2.41517
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 -2.41517
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta -2.41517
ACTA2 actin, alpha 2, smooth muscle, aorta -2.41517
MRO maestro -2.41517
SHISAL2A shisa like 2A -2.41517
RND2 Rho family GTPase 2 -2.41517
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -2.41517
TMEM121B transmembrane protein 121B -2.41517
DPY19L3 dpy-19-like 3 (C. elegans) -2.41517
SKIC2 SKI2 subunit of superkiller complex -2.41517
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase -2.41517
CPXM1 carboxypeptidase X (M14 family), member 1 -2.41412
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 -2.40018
CPB2 carboxypeptidase B2 (plasma) -2.38492
IFI6 interferon, alpha-inducible protein 6 -2.38492
GMFG glia maturation factor, gamma -2.38492
NOP9 NOP9 nucleolar protein -2.38492
SDK2 sidekick cell adhesion molecule 2 -2.38492
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -2.38492
PRSS21 protease, serine, 21 (testisin) -2.38492
OTX1 orthodenticle homeobox 1 -2.38492
SPINT4 serine peptidase inhibitor, Kunitz type 4 -2.38492
ASMT acetylserotonin O-methyltransferase -2.38492
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -2.38492
ERVFRD-1 endogenous retrovirus group FRD, member 1 -2.38492
AXDND1 axonemal dynein light chain domain containing 1 -2.38492
FLT3LG fms-related tyrosine kinase 3 ligand -2.38492
MOCOS molybdenum cofactor sulfurase -2.38492
CFAP100 cilia and flagella associated protein 100 -2.38492
ADGRG3 adhesion G protein-coupled receptor G3 -2.38492
UBE2L5 ubiquitin conjugating enzyme E2 L5 -2.38492
LY6L lymphocyte antigen 6 family member L -2.38492
POMC proopiomelanocortin -2.38492
LOC124900192 uncharacterized LOC124900192 -2.38492
SLC23A3 solute carrier family 23, member 3 -2.38492
MFAP4 microfibrillar-associated protein 4 -2.38492
MBLAC1 metallo-beta-lactamase domain containing 1 -2.38492
ZFP57 ZFP57 zinc finger protein -2.38492
SLC46A2 solute carrier family 46, member 2 -2.38492
MEP1B meprin A, beta -2.38492
ATP13A1 ATPase type 13A1 -2.38492
FOXD1 forkhead box D1 -2.38492
SPEGNB SPEG neighbor -2.38492
TEX29 testis expressed 29 -2.38492
WBP2NL WBP2 N-terminal like -2.38492
CSNK1G2 casein kinase 1, gamma 2 -2.38492
CLDN34 claudin 34 -2.38492
HCRT hypocretin (orexin) neuropeptide precursor -2.38492
CXCR4 chemokine (C-X-C motif) receptor 4 -2.38492
C17ORF99 chromosome 17 open reading frame 99 -2.38492
CXCR5 chemokine (C-X-C motif) receptor 5 -2.38492
TMEM204 transmembrane protein 204 -2.38492
CDH17 cadherin 17, LI cadherin (liver-intestine) -2.38492
ADAP1 ArfGAP with dual PH domains 1 -2.38492
CNR2 cannabinoid receptor 2 (macrophage) -2.38492
MMP3 matrix metallopeptidase 3 -2.38492
MPZL2 myelin protein zero-like 2 -2.38492
OXER1 oxoeicosanoid (OXE) receptor 1 -2.38492
AMDHD1 amidohydrolase domain containing 1 -2.38492
TMPRSS15 transmembrane protease, serine 15 -2.38492
CLNK cytokine-dependent hematopoietic cell linker -2.38492
ADAM20 ADAM metallopeptidase domain 20 -2.38492
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.37923
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -2.37779
KANSL2 KAT8 regulatory NSL complex subunit 2 -2.37288
CDR2 cerebellar degeneration-related protein 2, 62kDa -2.36263
PAGR1 PAXIP1 associated glutamate-rich protein 1 -2.32362
NCOA4 nuclear receptor coactivator 4 -2.31817
ITSN1 intersectin 1 (SH3 domain protein) -2.31817
IKZF2 IKAROS family zinc finger 2 (Helios) -2.31817
RCOR2 REST corepressor 2 -2.31581
ARHGAP31 Rho GTPase activating protein 31 -2.31581
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 -2.26828
CNRIP1 cannabinoid receptor interacting protein 1 -2.26492
BATF3 basic leucine zipper transcription factor, ATF-like 3 -2.2582
RAD51B RAD51 paralog B -2.25644
SYBU syntabulin (syntaxin-interacting) -2.24769
CLPSL1 colipase-like 1 -2.24769
AOAH acyloxyacyl hydrolase (neutrophil) -2.23425
TOX2 TOX high mobility group box family member 2 -2.20154
PRR14L proline rich 14-like -2.17798
AP2S1 adaptor-related protein complex 2, sigma 1 subunit -2.15844
METAP1 methionyl aminopeptidase 1 -2.15775
ZSCAN12 zinc finger and SCAN domain containing 12 -2.14195
KIFBP kinesin family binding protein -2.14195
ZBTB26 zinc finger and BTB domain containing 26 -2.13702
ZNF574 zinc finger protein 574 -2.13631
ITSN2 intersectin 2 -2.13055
METTL24 methyltransferase like 24 -2.12135
WNT5A wingless-type MMTV integration site family, member 5A -2.12135
INSYN2A inhibitory synaptic factor 2A -2.11724
DUSP23 dual specificity phosphatase 23 -2.11724
IQCJ IQ motif containing J -2.09952
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.0975
STK36 serine/threonine kinase 36 -2.08167
MRPL12 mitochondrial ribosomal protein L12 -2.06965
STS steroid sulfatase (microsomal), isozyme S -2.06855
PARP12 poly (ADP-ribose) polymerase family, member 12 -2.06459
FBXW8 F-box and WD repeat domain containing 8 -2.06459
AURKA aurora kinase A -2.05559
HLA-C major histocompatibility complex, class I, C -2.05204
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) -2.04322
SAP30L SAP30-like -2.04174
STAC2 SH3 and cysteine rich domain 2 -2.03945
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) -2.03446
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -2.03446
TACR3 tachykinin receptor 3 -2.03124
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 -2.02163
SPINK8 serine peptidase inhibitor, Kazal type 8 (putative) -2.02163
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit -2.00816
MORN1 MORN repeat containing 1 -2.00816