RNF139 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description ring finger protein 139|The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 11236)
External Link http://www.ncbi.nlm.nih.gov/gene/11236
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21 interacting proteins for RNF139 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AUP1 ancient ubiquitous protein 1
COPS5 COP9 signalosome subunit 5
EIF3A eukaryotic translation initiation factor 3, subunit A
ERLIN1 ER lipid raft associated 1
ERLIN2 ER lipid raft associated 2
HLA-C major histocompatibility complex, class I, C
HM13 histocompatibility (minor) 13
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
INSIG1 insulin induced gene 1
INSIG2 insulin induced gene 2
NRF1 nuclear respiratory factor 1
SCAP SREBF chaperone
SEC24B SEC24 family member B
SREBF2 sterol regulatory element binding transcription factor 2
TMUB1 transmembrane and ubiquitin-like domain containing 1
UBC ubiquitin C
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBE2H ubiquitin-conjugating enzyme E2H
UBE2U ubiquitin-conjugating enzyme E2U (putative)
UBE2Z ubiquitin-conjugating enzyme E2Z
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase