RNF2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ring finger protein 2|Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6045)
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Genes

341 genes differentially expressed following the RNF2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 3.88738
GRK7 G protein-coupled receptor kinase 7 3.88738
SHISA3 shisa family member 3 3.88738
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 3.88738
TLE6 transducin-like enhancer of split 6 3.88738
SPMIP7 sperm microtubule inner protein 7 3.88738
IL6 interleukin 6 3.88738
ISLR immunoglobulin superfamily containing leucine-rich repeat 3.88738
IL1A interleukin 1, alpha 3.88738
TBX20 T-box 20 3.88738
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 3.88738
ACOT12 acyl-CoA thioesterase 12 3.88738
IFITM10 interferon induced transmembrane protein 10 3.88738
PARP10 poly (ADP-ribose) polymerase family, member 10 3.88738
CD300A CD300a molecule 3.88738
LRRC55 leucine rich repeat containing 55 3.88738
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 3.88738
MGAM2 maltase-glucoamylase 2 (putative) 3.88738
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 3.88738
CATIP ciliogenesis associated TTC17 interacting protein 3.88738
POU4F1 POU class 4 homeobox 1 3.88738
PHOX2A paired-like homeobox 2a 3.88738
LRRC43 leucine rich repeat containing 43 3.88738
CNR2 cannabinoid receptor 2 (macrophage) 3.88738
SMIM43 small integral membrane protein 43 3.81902
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 3.81902
GNG5B G protein subunit gamma 5B 3.81902
GJA10 gap junction protein, alpha 10, 62kDa 3.81902
FETUB fetuin B 3.81902
MYBPC3 myosin binding protein C, cardiac 3.81902
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 3.81902
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 3.81902
TBX18 T-box 18 3.81902
DDN dendrin 3.81902
PCDHB6 protocadherin beta 6 3.81902
GLYATL1B glycine-N-acyltransferase like 1B 3.81902
LGALS9 lectin, galactoside-binding, soluble, 9 3.81902
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 3.81902
TREM1 triggering receptor expressed on myeloid cells 1 3.81902
CARD18 caspase recruitment domain family, member 18 3.81902
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 3.81902
PRRT1B proline rich transmembrane protein 1B 3.81902
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 3.81902
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 3.81902
THEMIS thymocyte selection associated 3.81902
TPPP tubulin polymerization promoting protein 3.81902
MYO1G myosin IG 3.81902
TRPC5OS TRPC5 opposite strand 3.81902
MUC22 mucin 22 3.81902
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 3.81902
WNT8B wingless-type MMTV integration site family, member 8B 3.81902
OR2A5 olfactory receptor, family 2, subfamily A, member 5 3.81902
SHE Src homology 2 domain containing E 3.81902
ZNF705D zinc finger protein 705D 3.81902
ERVFRD-1 endogenous retrovirus group FRD, member 1 3.81902
FABP12 fatty acid binding protein 12 3.81902
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 3.81902
EXOC1L exocyst complex component 1 like 3.81902
GUCY2F guanylate cyclase 2F, retinal 3.81902
SLC23A3 solute carrier family 23, member 3 3.81902
SLC10A5 solute carrier family 10, member 5 3.81902
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 3.81902
LAPTM5 lysosomal protein transmembrane 5 3.81902
OR10H1 olfactory receptor, family 10, subfamily H, member 1 3.81902
LRRC3C leucine rich repeat containing 3C 3.81902
C9 complement component 9 3.81902
ZAR1 zygote arrest 1 3.81902
ARMC12 armadillo repeat containing 12 3.81902
LRRC72 leucine rich repeat containing 72 3.81902
TMEM119 transmembrane protein 119 3.81902
HNF1B HNF1 homeobox B 3.81902
SYT15 synaptotagmin XV 3.81902
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 3.81902
CSAG2 CSAG family, member 2 3.81902
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 3.81902
VSIG2 V-set and immunoglobulin domain containing 2 3.81902
FOXC1 forkhead box C1 3.81902
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 3.81902
PDF peptide deformylase (mitochondrial) 3.81902
SIM1 single-minded family bHLH transcription factor 1 3.81902
TMEM275 transmembrane protein 275 3.81902
TPTE transmembrane phosphatase with tensin homology 3.81902
TCIM transcriptional and immune response regulator 3.81902
TMPRSS11F transmembrane protease, serine 11F 3.81902
CFHR3 complement factor H-related 3 3.81902
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 3.81902
TEX13C TEX13 family member C 3.81902
RAET1G retinoic acid early transcript 1G 3.81902
MSANTD5 Myb/SANT DNA binding domain containing 5 3.81902
FPR3 formyl peptide receptor 3 3.81902
RTL9 retrotransposon Gag like 9 3.81902
TMEM229A transmembrane protein 229A 3.81902
RAB41 RAB41, member RAS oncogene family 3.81902
CBLIF cobalamin binding intrinsic factor 3.81902
TBXT T-box transcription factor T 3.81902
DEPP1 DEPP autophagy regulator 1 3.81902
MAG myelin associated glycoprotein 3.81902
CKM creatine kinase, muscle 3.81902
SLC22A25 solute carrier family 22, member 25 3.81902
SIM2 single-minded family bHLH transcription factor 2 3.81902
ACER1 alkaline ceramidase 1 3.81902
LOC102724877 uncharacterized LOC102724877 3.81902
CCL15 chemokine (C-C motif) ligand 15 3.81902
NIM1K NIM1 serine/threonine protein kinase 3.81902
OTOP2 otopetrin 2 3.81902
NT5C1B 5'-nucleotidase, cytosolic IB 3.81902
VAX2 ventral anterior homeobox 2 3.81902
IBSP integrin-binding sialoprotein 3.81902
ALAS2 5'-aminolevulinate synthase 2 3.81902
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 3.81902
ZMYND15 zinc finger, MYND-type containing 15 3.81902
PCDHGB5 protocadherin gamma subfamily B, 5 3.81902
BCL2L15 BCL2-like 15 3.81902
TOPAZ1 testis and ovary specific PAZ domain containing 1 3.81902
FZD1 frizzled class receptor 1 3.81902
WDFY4 WDFY family member 4 3.81902
MOS v-mos Moloney murine sarcoma viral oncogene homolog 3.81902
ANKRD33 ankyrin repeat domain 33 3.81902
RAD51AP2 RAD51 associated protein 2 3.81902
GRK1 G protein-coupled receptor kinase 1 3.81902
MYLK2 myosin light chain kinase 2 3.81902
MUC13 mucin 13, cell surface associated 3.81902
HELT helt bHLH transcription factor 3.81902
COX7B2 cytochrome c oxidase subunit VIIb2 3.81902
KLK12 kallikrein-related peptidase 12 3.81902
DRD5 dopamine receptor D5 3.81902
TRIM55 tripartite motif containing 55 3.81902
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.81902
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 3.81902
MAB21L1 mab-21-like 1 (C. elegans) 3.81902
PIP prolactin-induced protein 3.81902
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3.81902
WFDC9 WAP four-disulfide core domain 9 3.81902
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 3.81902
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.81902
BTNL8 butyrophilin-like 8 3.81902
C9ORF50 chromosome 9 open reading frame 50 3.81902
EPX eosinophil peroxidase 3.81902
CCNI2 cyclin I family, member 2 3.81902
RHAG Rh-associated glycoprotein 3.81902
NPC1L1 NPC1-like 1 3.81902
ZPBP zona pellucida binding protein 3.81902
LPO lactoperoxidase 3.81902
ASCL2 achaete-scute family bHLH transcription factor 2 3.81902
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 3.81902
HLA-DMB major histocompatibility complex, class II, DM beta 3.81902
TEX26 testis expressed 26 3.81902
SLC38A11 solute carrier family 38, member 11 3.81902
ANGPTL7 angiopoietin-like 7 3.81902
FAM180A family with sequence similarity 180, member A 3.81902
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.81902
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 3.81902
NKPD1 NTPase, KAP family P-loop domain containing 1 3.81902
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 3.81902
OR13G1 olfactory receptor, family 13, subfamily G, member 1 3.81902
TWIST1 twist family bHLH transcription factor 1 3.81902
EFCC1 EF-hand and coiled-coil domain containing 1 3.81902
POTEE POTE ankyrin domain family, member E 3.81902
FXYD3 FXYD domain containing ion transport regulator 3 3.81902
LDLRAD1 low density lipoprotein receptor class A domain containing 1 3.81902
FGF6 fibroblast growth factor 6 3.81902
FGF17 fibroblast growth factor 17 3.81902
CAPSL calcyphosine-like 3.81902
TRIML1 tripartite motif family-like 1 3.81902
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 3.81902
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 3.72922
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 3.27356
TMEM269 transmembrane protein 269 3.21531
ACOT6 acyl-CoA thioesterase 6 3.21531
CHODL chondrolectin 3.11915
DENR density-regulated protein 3.0831
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 3.05608
MT1G metallothionein 1G 3.05029
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 3.04684
WDR76 WD repeat domain 76 3.04684
MRPL37 mitochondrial ribosomal protein L37 3.00761
BAIAP3 BAI1-associated protein 3 2.93414
BNIPL BCL2/adenovirus E1B 19kD interacting protein like 2.86309
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 2.84854
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae) 2.82086
NHLRC2 NHL repeat containing 2 2.80573
RALBP1 ralA binding protein 1 2.72997
PAQR9 progestin and adipoQ receptor family member IX 2.70226
COL10A1 collagen, type X, alpha 1 2.70115
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like 2.68672
NOD2 nucleotide-binding oligomerization domain containing 2 2.66978
GPR20 G protein-coupled receptor 20 2.66978
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 2.61723
MUC4 mucin 4, cell surface associated 2.51914
DESI2 desumoylating isopeptidase 2 2.51288
RIT1 Ras-like without CAAX 1 2.48847
TMEM222 transmembrane protein 222 2.48052
SYN1 synapsin I 2.43489
TOP3B topoisomerase (DNA) III beta 2.43238
GMNN geminin, DNA replication inhibitor 2.4287
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 2.4287
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 2.4241
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa 2.42001
LPCAT1 lysophosphatidylcholine acyltransferase 1 2.39978
PHF19 PHD finger protein 19 2.39825
TMEM69 transmembrane protein 69 2.39594
PIRT phosphoinositide-interacting regulator of transient receptor potential channels 2.37761
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.37761
PCDHB13 protocadherin beta 13 2.355
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.355
SIX1 SIX homeobox 1 2.34005
BCAS1 breast carcinoma amplified sequence 1 2.34005
HMGB2 high mobility group box 2 2.33677
DHCR24 24-dehydrocholesterol reductase 2.33555
IQSEC1 IQ motif and Sec7 domain 1 2.33416
NR6A1 nuclear receptor subfamily 6, group A, member 1 2.32705
NFIA nuclear factor I/A 2.31933
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 2.29233
LRRC24 leucine rich repeat containing 24 2.29233
CNFN cornifelin 2.29233
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2.29067
CTPS2 CTP synthase 2 2.24974
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 2.22379
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 2.2201
ZRANB1 zinc finger, RAN-binding domain containing 1 2.21215
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 2.1633
WSCD2 WSC domain containing 2 2.15877
ACTG2 actin, gamma 2, smooth muscle, enteric 2.15877
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 2.13235
LIMA1 LIM domain and actin binding 1 2.08502
ADPRHL1 ADP-ribosylhydrolase like 1 2.08502
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 2.07463
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 2.04742
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 2.03966
TCF25 transcription factor 25 (basic helix-loop-helix) 2.02957
RNF167 ring finger protein 167 2.02625
ZSWIM6 zinc finger, SWIM-type containing 6 2.02625
EPC1 enhancer of polycomb homolog 1 (Drosophila) 2.02444
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.02444
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 2.01949
MT1F metallothionein 1F 2.01512
SPATC1L spermatogenesis and centriole associated 1-like 2.01512
RPL22 ribosomal protein L22 2.00862

decreased expression

Symbol Name Standardized Value
KLF4 Kruppel-like factor 4 (gut) -3.88738
ZNF723 zinc finger protein 723 -3.88738
MGARP mitochondria-localized glutamic acid-rich protein -3.88738
FBXO32 F-box protein 32 -3.88738
SNX31 sorting nexin 31 -3.88738
GPNMB glycoprotein (transmembrane) nmb -3.88738
ZNF285 zinc finger protein 285 -3.88738
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) -3.81902
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 -3.81902
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 -3.81902
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -3.81902
MAPK11 mitogen-activated protein kinase 11 -3.81902
HCRT hypocretin (orexin) neuropeptide precursor -3.81902
C11ORF96 chromosome 11 open reading frame 96 -3.81902
ZNF396 zinc finger protein 396 -3.81902
NR4A3 nuclear receptor subfamily 4, group A, member 3 -3.81902
UBE2L5 ubiquitin conjugating enzyme E2 L5 -3.81902
FIMP1 fertilization-influencing membrane protein 1 -3.81902
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -3.81902
ACSL5 acyl-CoA synthetase long-chain family member 5 -3.81902
SCIMP SLP adaptor and CSK interacting membrane protein -3.81902
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -3.81902
FAM3D family with sequence similarity 3, member D -3.81902
ZNF99 zinc finger protein 99 -3.81902
MAP3K7CL MAP3K7 C-terminal like -3.81902
CRIP1 cysteine-rich protein 1 (intestinal) -3.81902
CIMAP1D CIMAP1 family member D -3.81902
GTF2A1L general transcription factor IIA, 1-like -3.81902
NTN5 netrin 5 -3.81902
SYNGR4 synaptogyrin 4 -3.81902
EFCAB12 EF-hand calcium binding domain 12 -3.81902
TMPRSS4 transmembrane protease, serine 4 -3.81902
ADRA2A adrenoceptor alpha 2A -3.81902
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -3.81902
TUBB3 tubulin, beta 3 class III -3.52668
SYNC syncoilin, intermediate filament protein -3.4027
JPH4 junctophilin 4 -3.22317
PMPCA peptidase (mitochondrial processing) alpha -3.21943
FBXL7 F-box and leucine-rich repeat protein 7 -3.16454
SCUBE2 signal peptide, CUB domain, EGF-like 2 -3.13076
UBN1 ubinuclein 1 -2.97685
MROH8 maestro heat-like repeat family member 8 -2.85387
PKD1L1 polycystic kidney disease 1 like 1 -2.85387
DPP10 dipeptidyl-peptidase 10 (non-functional) -2.71561
TRAP1 TNF receptor-associated protein 1 -2.67607
TNNC1 troponin C type 1 (slow) -2.65731
ZNF699 zinc finger protein 699 -2.64043
PEX5L peroxisomal biogenesis factor 5-like -2.63629
RNF2 ring finger protein 2 -2.5351
KMT2D lysine (K)-specific methyltransferase 2D -2.52832
GRID2 glutamate receptor, ionotropic, delta 2 -2.51045
BICDL2 BICD family like cargo adaptor 2 -2.50389
ZNF571 zinc finger protein 571 -2.49232
RBM33 RNA binding motif protein 33 -2.46627
SYP synaptophysin -2.46454
WDR77 WD repeat domain 77 -2.46454
KIF3C kinesin family member 3C -2.43135
MUC19 mucin 19, oligomeric -2.4287
VWF von Willebrand factor -2.4287
USP50 ubiquitin specific peptidase 50 -2.4287
AKR1C1 aldo-keto reductase family 1, member C1 -2.42054
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -2.42001
FOXL2 forkhead box L2 -2.41663
NPM2 nucleophosmin/nucleoplasmin 2 -2.41663
OIP5 Opa interacting protein 5 -2.41306
EMC9 ER membrane protein complex subunit 9 -2.40091
NCF2 neutrophil cytosolic factor 2 -2.39224
TFPI2 tissue factor pathway inhibitor 2 -2.37559
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -2.36069
PRDX4 peroxiredoxin 4 -2.355
SOD2 superoxide dismutase 2, mitochondrial -2.33677
LRRC4C leucine rich repeat containing 4C -2.33555
SLMAP sarcolemma associated protein -2.31891
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 -2.2771
SLCO1B1 solute carrier organic anion transporter family, member 1B1 -2.26284
ZNG1B Zn regulated GTPase metalloprotein activator 1B -2.25644
PCP4L1 Purkinje cell protein 4 like 1 -2.25402
C1ORF159 chromosome 1 open reading frame 159 -2.25203
CDH13 cadherin 13 -2.25203
ZNF547 zinc finger protein 547 -2.25203
LCN2 lipocalin 2 -2.25203
COL6A6 collagen, type VI, alpha 6 -2.25203
PIP4P1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 -2.24593
CNPY4 canopy FGF signaling regulator 4 -2.23568
MRPL14 mitochondrial ribosomal protein L14 -2.23015
FBXO38 F-box protein 38 -2.20075
SYPL1 synaptophysin-like 1 -2.20075
RNF152 ring finger protein 152 -2.17467
PROSER2 proline and serine rich 2 -2.17467
ANKRD35 ankyrin repeat domain 35 -2.15877
OSBPL10 oxysterol binding protein-like 10 -2.14265
SNAP23 synaptosomal-associated protein, 23kDa -2.12276
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -2.12276
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) -2.1027
TSEN54 TSEN54 tRNA splicing endonuclease subunit -2.1027
IFI35 interferon-induced protein 35 -2.08888
GLI1 GLI family zinc finger 1 -2.08003
HERPUD2 HERPUD family member 2 -2.06576
GRIA1 glutamate receptor, ionotropic, AMPA 1 -2.05393
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) -2.04963
SELENOV selenoprotein V -2.03688
AASDH aminoadipate-semialdehyde dehydrogenase -2.028
SH3BP4 SH3-domain binding protein 4 -2.01061