RNF8 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ring finger protein 8, E3 ubiquitin protein ligase|The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] (NCBI Entrez Gene Database, 9025)
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Genes

330 genes differentially expressed following the RNF8 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MISP3 MISP family member 3 2.80721
MCHR2 melanin-concentrating hormone receptor 2 2.80721
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2.80721
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.80721
PGAM2 phosphoglycerate mutase 2 (muscle) 2.80721
TMPRSS6 transmembrane protease, serine 6 2.80721
HAMP hepcidin antimicrobial peptide 2.80721
PCDHGA3 protocadherin gamma subfamily A, 3 2.80721
TMEM151A transmembrane protein 151A 2.80721
GATA6 GATA binding protein 6 2.80721
CLDN5 claudin 5 2.80721
MYO16 myosin XVI 2.80721
CTXND1 cortexin domain containing 1 2.80721
SPATA31H1 SPATA31 subfamily H member 1 2.80721
FAM181B family with sequence similarity 181, member B 2.80721
ZNF98 zinc finger protein 98 2.80721
CFAP299 cilia and flagella associated protein 299 2.80721
CATSPERT catsper channel auxiliary subunit tau 2.80721
PNMA6F PNMA family member 6F 2.80721
UPB1 ureidopropionase, beta 2.7738
CASP4 caspase 4, apoptosis-related cysteine peptidase 2.7738
HES7 hes family bHLH transcription factor 7 2.7738
RRAD Ras-related associated with diabetes 2.7738
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.7738
PDIA2 protein disulfide isomerase family A, member 2 2.7738
ADRB2 adrenoceptor beta 2, surface 2.7738
PLVAP plasmalemma vesicle associated protein 2.7738
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.7738
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.7738
FER1L6 fer-1-like family member 6 2.7738
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.7738
MAP3K7CL MAP3K7 C-terminal like 2.7738
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 2.7738
HLF hepatic leukemia factor 2.7738
OR10A6 olfactory receptor, family 10, subfamily A, member 6 (gene/pseudogene) 2.7738
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 2.7738
C1ORF146 chromosome 1 open reading frame 146 2.7738
PEAR1 platelet endothelial aggregation receptor 1 2.7738
TMEM71 transmembrane protein 71 2.7738
SMIM5 small integral membrane protein 5 2.7738
TTLL8 tubulin tyrosine ligase-like family member 8 2.7738
TMEM89 transmembrane protein 89 2.7738
PNOC prepronociceptin 2.7738
RFX6 regulatory factor X, 6 2.7738
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.7738
SFTPB surfactant protein B 2.7738
HAS1 hyaluronan synthase 1 2.7738
CXORF65 chromosome X open reading frame 65 2.7738
GJA10 gap junction protein, alpha 10, 62kDa 2.7738
OR2J3 olfactory receptor, family 2, subfamily J, member 3 2.7738
PAX6 paired box 6 2.7738
OLFM4 olfactomedin 4 2.7738
PECAM1 platelet/endothelial cell adhesion molecule 1 2.7738
LYZL6 lysozyme-like 6 2.7738
RFPL2 ret finger protein-like 2 2.7738
ADGB androglobin 2.7738
ZFYVE27 zinc finger, FYVE domain containing 27 2.7738
TAS2R5 taste receptor, type 2, member 5 2.7738
TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough 2.7738
PKD2L1 polycystic kidney disease 2-like 1 2.7738
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 2.7738
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.7738
TMPRSS3 transmembrane protease, serine 3 2.7738
IQCF1 IQ motif containing F1 2.7738
SMPX small muscle protein, X-linked 2.7738
FCMR Fc fragment of IgM receptor 2.7738
GRAP GRB2-related adaptor protein 2.7738
MYL10 myosin, light chain 10, regulatory 2.7738
STMN4 stathmin-like 4 2.7738
SCEL sciellin 2.7738
SMIM32 small integral membrane protein 32 2.7738
CIMAP1B ciliary microtubule associated protein 1B 2.7738
H2BC12L H2B clustered histone 12 like 2.7738
H4C14 H4 clustered histone 14 2.7738
FLACC1 flagellum associated containing coiled-coil domains 1 2.7738
CIROP ciliated left-right organizer metallopeptidase 2.7738
JAML junction adhesion molecule like 2.7738
RTL9 retrotransposon Gag like 9 2.7738
OR10H5 olfactory receptor, family 10, subfamily H, member 5 2.7738
ZNF443 zinc finger protein 443 2.7738
KHDC1L KH homology domain containing 1-like 2.7738
F8 coagulation factor VIII, procoagulant component 2.7738
ANXA13 annexin A13 2.7738
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.7738
PTGDR2 prostaglandin D2 receptor 2 2.7738
C4ORF17 chromosome 4 open reading frame 17 2.7738
PCDHB11 protocadherin beta 11 2.7738
MTNR1B melatonin receptor 1B 2.7738
DTHD1 death domain containing 1 2.7738
OR2A7 olfactory receptor, family 2, subfamily A, member 7 2.7738
SYCP2 synaptonemal complex protein 2 2.7738
NPIPB9 nuclear pore complex interacting protein family, member B9 2.7738
PDZK1IP1 PDZK1 interacting protein 1 2.7738
OSTN osteocrin 2.7738
MLANA melan-A 2.7738
NDP Norrie disease (pseudoglioma) 2.7738
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 2.7738
PLEK2 pleckstrin 2 2.7738
OOSP1 oocyte secreted protein 1, pseudogene 2.7738
PGLYRP1 peptidoglycan recognition protein 1 2.7738
CCR7 chemokine (C-C motif) receptor 7 2.7738
INSRR insulin receptor-related receptor 2.7738
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.7738
MAB21L1 mab-21-like 1 (C. elegans) 2.7738
ZSCAN4 zinc finger and SCAN domain containing 4 2.7738
FBXO47 F-box protein 47 2.7738
KLK3 kallikrein-related peptidase 3 2.7738
WNT7B wingless-type MMTV integration site family, member 7B 2.7738
PRPH peripherin 2.7738
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.7738
EPHA10 EPH receptor A10 2.7738
TCF21 transcription factor 21 2.7738
LY96 lymphocyte antigen 96 2.7738
IL12B interleukin 12B 2.7738
KIF4B kinesin family member 4B 2.7738
ADGRF5 adhesion G protein-coupled receptor F5 2.7738
AMN amnion associated transmembrane protein 2.7738
CLEC9A C-type lectin domain family 9, member A 2.7738
SIGLEC15 sialic acid binding Ig-like lectin 15 2.7738
KLK11 kallikrein-related peptidase 11 2.7738
PLA1A phospholipase A1 member A 2.7738
HUS1B HUS1 checkpoint homolog b (S. pombe) 2.7738
PCDHGA7 protocadherin gamma subfamily A, 7 2.7738
CLEC4D C-type lectin domain family 4, member D 2.7738
CDH19 cadherin 19, type 2 2.7738
TPSB2 tryptase beta 2 (gene/pseudogene) 2.7738
MCCD1 mitochondrial coiled-coil domain 1 2.7738
CDHR4 cadherin-related family member 4 2.7738
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.7738
CCDC179 coiled-coil domain containing 179 2.7738
C17ORF99 chromosome 17 open reading frame 99 2.7738
ISLR immunoglobulin superfamily containing leucine-rich repeat 2.7738
ANKRD63 ankyrin repeat domain 63 2.7738
KCNS2 potassium voltage-gated channel, modifier subfamily S, member 2 2.7738
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 2.7738
SIAH3 siah E3 ubiquitin protein ligase family member 3 2.7738
ZBED6 zinc finger, BED-type containing 6 2.7738
GSTA1 glutathione S-transferase alpha 1 2.7738
DLX5 distal-less homeobox 5 2.7738
TEX38 testis expressed 38 2.7738
AREG amphiregulin 2.7738
NKX6-3 NK6 homeobox 3 2.7738
HIGD1C HIG1 hypoxia inducible domain family, member 1C 2.7738
LDLRAD1 low density lipoprotein receptor class A domain containing 1 2.7738
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.7738
HPGDS hematopoietic prostaglandin D synthase 2.7738
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 2.7738
OPALIN oligodendrocytic myelin paranodal and inner loop protein 2.7738
PPP1R27 protein phosphatase 1, regulatory subunit 27 2.7738
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.7738
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.7738
TEX26 testis expressed 26 2.7738
ETV2 ets variant 2 2.7738
API5 apoptosis inhibitor 5 2.7738
SLC25A34 solute carrier family 25, member 34 2.7738
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.7738
PENK proenkephalin 2.7738
TMPRSS13 transmembrane protease, serine 13 2.7738
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 2.7738
ST18 suppression of tumorigenicity 18, zinc finger 2.7738
ANGPTL6 angiopoietin-like 6 2.7738
DTNBP1 dystrobrevin binding protein 1 2.7738
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.7738
NLRP6 NLR family, pyrin domain containing 6 2.7738
GCGR glucagon receptor 2.7738
NLRP3 NLR family, pyrin domain containing 3 2.7738
EFCC1 EF-hand and coiled-coil domain containing 1 2.7738
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 2.7738
MROH2A maestro heat-like repeat family member 2A 2.7738
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.7738
GOLPH3 golgi phosphoprotein 3 (coat-protein) 2.76994
ZNF407 zinc finger protein 407 2.73352
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) 2.69336
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.58014
TBC1D5 TBC1 domain family, member 5 2.5743
DNAAF11 dynein axonemal assembly factor 11 2.54852
RPA3 replication protein A3, 14kDa 2.51439
TOR1AIP1 torsin A interacting protein 1 2.50056
TSSK3 testis-specific serine kinase 3 2.48992
DEGS2 delta(4)-desaturase, sphingolipid 2 2.43368
PLS3 plastin 3 2.43129
CD72 CD72 molecule 2.42247
HAS3 hyaluronan synthase 3 2.40846
YY1AP1 YY1 associated protein 1 2.40846
GUSB glucuronidase, beta 2.38907
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.38364
HRG histidine-rich glycoprotein 2.37137
UBE3D ubiquitin protein ligase E3D 2.36061
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 2.36061
TBC1D12 TBC1 domain family, member 12 2.36061
PHF20 PHD finger protein 20 2.36061
MRPS16 mitochondrial ribosomal protein S16 2.35993
SPPL3 signal peptide peptidase like 3 2.35581
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 2.34555
TSPAN5 tetraspanin 5 2.33153
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 2.32632
CKMT1A creatine kinase, mitochondrial 1A 2.2871
NPAS2 neuronal PAS domain protein 2 2.25656
NID1 nidogen 1 2.25169
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 2.24497
ZNF85 zinc finger protein 85 2.24217
H3C7 H3 clustered histone 7 2.23434
BBS9 Bardet-Biedl syndrome 9 2.23105
EZR ezrin 2.23076
ACBD3 acyl-CoA binding domain containing 3 2.22545
ELMO1 engulfment and cell motility 1 2.18927
PXDNL peroxidasin-like 2.17729
RBP1 retinol binding protein 1, cellular 2.16735
ADSS2 adenylosuccinate synthase 2 2.16266
FBXL5 F-box and leucine-rich repeat protein 5 2.15161
TRAF2 TNF receptor-associated factor 2 2.13012
SUMF1 sulfatase modifying factor 1 2.11935
ZNF2 zinc finger protein 2 2.10832
ANKRD52 ankyrin repeat domain 52 2.09716
MCOLN2 mucolipin 2 2.08851
ZNF883 zinc finger protein 883 2.08528
FHIT fragile histidine triad 2.0778
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) 2.07477
LDOC1 leucine zipper, down-regulated in cancer 1 2.07477
NOMO3 NODAL modulator 3 2.0568
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 2.0559
RAD54L2 RAD54-like 2 (S. cerevisiae) 2.05083
NPAT nuclear protein, ataxia-telangiectasia locus 2.0425
ANAPC4 anaphase promoting complex subunit 4 2.04079
ECH1 enoyl CoA hydratase 1, peroxisomal 2.03615
CAPRIN1 cell cycle associated protein 1 2.01551
USP20 ubiquitin specific peptidase 20 2.00353

decreased expression

Symbol Name Standardized Value
UPK3B uroplakin 3B -2.80721
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta -2.80721
ZSCAN20 zinc finger and SCAN domain containing 20 -2.80721
OR56A1 olfactory receptor, family 56, subfamily A, member 1 -2.80721
SUMO4 small ubiquitin-like modifier 4 -2.80721
LRRC61 leucine rich repeat containing 61 -2.80721
ATP13A4 ATPase type 13A4 -2.7738
EBF2 early B-cell factor 2 -2.7738
TBX22 T-box 22 -2.7738
GABRD gamma-aminobutyric acid (GABA) A receptor, delta -2.7738
ZNF675 zinc finger protein 675 -2.7738
USH1G Usher syndrome 1G (autosomal recessive) -2.7738
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -2.7738
GDNF glial cell derived neurotrophic factor -2.7738
SCIN scinderin -2.7738
VIPR2 vasoactive intestinal peptide receptor 2 -2.7738
KHDC3L KH domain containing 3-like, subcortical maternal complex member -2.7738
MMP12 matrix metallopeptidase 12 -2.7738
RTN4RL1 reticulon 4 receptor-like 1 -2.7738
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 -2.7738
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -2.7738
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -2.7738
NFAM1 NFAT activating protein with ITAM motif 1 -2.7738
BBS2 Bardet-Biedl syndrome 2 -2.7738
CCL25 chemokine (C-C motif) ligand 25 -2.7738
HKDC1 hexokinase domain containing 1 -2.7738
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) -2.7738
KRT86 keratin 86, type II -2.7738
SQOR sulfide quinone oxidoreductase -2.7738
TF transferrin -2.7738
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 -2.7738
VEGFD vascular endothelial growth factor D -2.7738
HJV hemojuvelin BMP co-receptor -2.7738
SYT15B synaptotagmin 15B -2.7738
CEND1 cell cycle exit and neuronal differentiation 1 -2.7738
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.7738
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) -2.7738
UBQLNL ubiquilin-like -2.7738
RBM44 RNA binding motif protein 44 -2.7738
RAB36 RAB36, member RAS oncogene family -2.7738
JAKMIP3 Janus kinase and microtubule interacting protein 3 -2.7738
CNKSR1 connector enhancer of kinase suppressor of Ras 1 -2.77035
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -2.71742
PHLDA1 pleckstrin homology-like domain, family A, member 1 -2.70995
PRSS51 protease, serine, 51 -2.68225
NPB neuropeptide B -2.61798
KIAA2012 KIAA2012 -2.61798
PCDHGA8 protocadherin gamma subfamily A, 8 -2.61798
VASN vasorin -2.51786
ZNF776 zinc finger protein 776 -2.50056
KRCC1 lysine-rich coiled-coil 1 -2.4847
PRKDC protein kinase, DNA-activated, catalytic polypeptide -2.47707
MCM5 minichromosome maintenance complex component 5 -2.47441
CARS1 cysteinyl-tRNA synthetase 1 -2.43331
DSCC1 DNA replication and sister chromatid cohesion 1 -2.41002
MAT2A methionine adenosyltransferase II, alpha -2.40846
ERICH2 glutamate-rich 2 -2.38905
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -2.36228
NAGS N-acetylglutamate synthase -2.36214
EID2 EP300 interacting inhibitor of differentiation 2 -2.36061
PLCL1 phospholipase C-like 1 -2.36061
EGLN1 egl-9 family hypoxia-inducible factor 1 -2.35993
ELMOD3 ELMO/CED-12 domain containing 3 -2.3592
ZNF584 zinc finger protein 584 -2.34555
ZNF624 zinc finger protein 624 -2.34146
PTCHD4 patched domain containing 4 -2.34079
PCED1A PC-esterase domain containing 1A -2.33153
ZNF92 zinc finger protein 92 -2.31806
ZCCHC4 zinc finger, CCHC domain containing 4 -2.29677
PORCN porcupine homolog (Drosophila) -2.29119
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -2.29119
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated -2.26782
MSR1 macrophage scavenger receptor 1 -2.25903
GPR157 G protein-coupled receptor 157 -2.24853
TMUB2 transmembrane and ubiquitin-like domain containing 2 -2.24497
TEX261 testis expressed 261 -2.23434
ZNF99 zinc finger protein 99 -2.21107
FAM3B family with sequence similarity 3, member B -2.21107
POMC proopiomelanocortin -2.21107
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A -2.21107
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 -2.20464
KRT10 keratin 10, type I -2.17946
FAM114A2 family with sequence similarity 114, member A2 -2.17726
CLMN calmin (calponin-like, transmembrane) -2.16249
FAM162A family with sequence similarity 162, member A -2.15855
VWC2 von Willebrand factor C domain containing 2 -2.15446
TMX2 thioredoxin-related transmembrane protein 2 -2.15161
REXO2 RNA exonuclease 2 -2.1332
SKAP1 src kinase associated phosphoprotein 1 -2.09928
BSDC1 BSD domain containing 1 -2.09928
DMAP1 DNA methyltransferase 1 associated protein 1 -2.09497
EGFL6 EGF-like-domain, multiple 6 -2.08768
MIF4GD MIF4G domain containing -2.07794
HTATSF1 HIV-1 Tat specific factor 1 -2.07477
TBCC tubulin folding cofactor C -2.07477
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 -2.05212
FDXR ferredoxin reductase -2.0425
PDLIM1 PDZ and LIM domain 1 -2.03947
ULK3 unc-51 like kinase 3 -2.03823
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 -2.02952
MAX MYC associated factor X -2.02302
EMC6 ER membrane protein complex subunit 6 -2.02302
INSIG1 insulin induced gene 1 -2.01507