RNF8 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description ring finger protein 8, E3 ubiquitin protein ligase|The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] (NCBI Entrez Gene Database, 9025)
External Link http://www.ncbi.nlm.nih.gov/gene/9025
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Genes

54 interacting proteins for RNF8 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ATM ATM serine/threonine kinase
BCL10 B-cell CLL/lymphoma 10
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
CCDC85B coiled-coil domain containing 85B
CEP44 centrosomal protein 44kDa
CHD4 chromodomain helicase DNA binding protein 4
CHEK2 checkpoint kinase 2
DCLRE1C DNA cross-link repair 1C
EXOSC2 exosome component 2
H2AFX H2A histone family, member X
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HIST2H2AC histone cluster 2, H2ac
HIST2H2BE histone cluster 2, H2be
JMJD1C jumonji domain containing 1C
KDM4A lysine (K)-specific demethylase 4A
MCPH1 microcephalin 1
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MGMT O-6-methylguanine-DNA methyltransferase
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NBN nibrin
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NRF1 nuclear respiratory factor 1
ORC2 origin recognition complex, subunit 2
PCNA proliferating cell nuclear antigen
PNMA2 paraneoplastic Ma antigen 2
RAD50 RAD50 homolog (S. cerevisiae)
RPS27A ribosomal protein S27a
RPSA ribosomal protein SA
RXRA retinoid X receptor, alpha
SEPT7 septin 7
SEPT8 septin 8
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TP53BP1 tumor protein p53 binding protein 1
TRIM28 tripartite motif containing 28
UBB ubiquitin B
UBC ubiquitin C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2E2 ubiquitin-conjugating enzyme E2E 2
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE2N ubiquitin-conjugating enzyme E2N
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2
UBE2W ubiquitin-conjugating enzyme E2W (putative)
WASL Wiskott-Aldrich syndrome-like
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
YEATS4 YEATS domain containing 4