ROBO1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description roundabout, axon guidance receptor, homolog 1 (Drosophila)|Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] (NCBI Entrez Gene Database, 6091)
External Link http://www.ncbi.nlm.nih.gov/gene/6091
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Genes

34 interacting proteins for ROBO1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABI2 abl-interactor 2
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CYFIP1 cytoplasmic FMR1 interacting protein 1
DCC DCC netrin 1 receptor
GPC1 glypican 1
MAPK12 mitogen-activated protein kinase 12
MAPK14 mitogen-activated protein kinase 14
NCKAP1 NCK-associated protein 1
NTN1 netrin 1
NTN3 netrin 3
NTN4 netrin 4
NTNG1 netrin G1
NTNG2 netrin G2
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RHOC ras homolog family member C
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila)
SLIT1 slit homolog 1 (Drosophila)
SLIT2 slit homolog 2 (Drosophila)
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
TUBB3 tubulin, beta 3 class III
TUBB4A tubulin, beta 4A class IVa
UBC ubiquitin C
USP33 ubiquitin specific peptidase 33
WASF1 WAS protein family, member 1