ROCK2 Gene Set

Dataset KEA Substrates of Kinases
Category physical interactions
Type kinase
Description Rho-associated, coiled-coil containing protein kinase 2|The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9475)
External Link http://www.ncbi.nlm.nih.gov/gene/9475
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Genes

27 substrates of the kinase ROCK2 from the curated KEA Substrates of Kinases dataset.

Symbol Name
ADD1 adducin 1 (alpha)
APP amyloid beta (A4) precursor protein
ARHGAP1 Rho GTPase activating protein 1
BACE1 beta-site APP-cleaving enzyme 1
CAPZB capping protein (actin filament) muscle Z-line, beta
CNN3 calponin 3, acidic
DES desmin
DPYSL2 dihydropyrimidinase-like 2
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EZR ezrin
GFAP glial fibrillary acidic protein
IRF4 interferon regulatory factor 4
IRS1 insulin receptor substrate 1
LIMK1 LIM domain kinase 1
LIMK2 LIM domain kinase 2
MAGEC1 melanoma antigen family C1
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MSN moesin
MYL12B myosin, light chain 12B, regulatory
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
RDX radixin
SH3GL2 SH3-domain GRB2-like 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TNNI3 troponin I type 3 (cardiac)
VIM vimentin