ROCK2 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description Rho-associated, coiled-coil containing protein kinase 2|The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9475)
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Genes

100 substrates of the kinase ROCK2 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
NCBP1 nuclear cap binding protein subunit 1, 80kDa
ZNF106 zinc finger protein 106
C19ORF26 chromosome 19 open reading frame 26
SAP30L SAP30-like
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11
KIAA1671 KIAA1671
TP53RK TP53 regulating kinase
BTK Bruton agammaglobulinemia tyrosine kinase
PRICKLE3 prickle homolog 3 (Drosophila)
C11ORF30 chromosome 11 open reading frame 30
HEXIM1 hexamethylene bis-acetamide inducible 1
WNK1 WNK lysine deficient protein kinase 1
PLXNB1 plexin B1
BRCA1 breast cancer 1, early onset
KIF23 kinesin family member 23
PLK1 polo-like kinase 1
KAT5 K(lysine) acetyltransferase 5
TRA2A transformer 2 alpha homolog (Drosophila)
PPP1R8 protein phosphatase 1, regulatory subunit 8
PDE3A phosphodiesterase 3A, cGMP-inhibited
PDE3B phosphodiesterase 3B, cGMP-inhibited
HIST1H2BB histone cluster 1, H2bb
SCAF1 SR-related CTD-associated factor 1
HEATR3 HEAT repeat containing 3
TOR4A torsin family 4, member A
DMXL1 Dmx-like 1
CREBZF CREB/ATF bZIP transcription factor
THOC5 THO complex 5
CASKIN1 CASK interacting protein 1
PBRM1 polybromo 1
FRMD4B FERM domain containing 4B
PELI1 pellino E3 ubiquitin protein ligase 1
VASP vasodilator-stimulated phosphoprotein
SF3B1 splicing factor 3b, subunit 1, 155kDa
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
CENPA centromere protein A
DEPDC5 DEP domain containing 5
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
MYO3A myosin IIIA
RACGAP1 Rac GTPase activating protein 1
BAHD1 bromo adjacent homology domain containing 1
TRPS1 trichorhinophalangeal syndrome I
MVD mevalonate (diphospho) decarboxylase
SOX9 SRY (sex determining region Y)-box 9
SRSF2 serine/arginine-rich splicing factor 2
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MLPH melanophilin
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
PYGO2 pygopus family PHD finger 2
DAPK3 death-associated protein kinase 3
GPR15 G protein-coupled receptor 15
MAP3K11 mitogen-activated protein kinase kinase kinase 11
RARG retinoic acid receptor, gamma
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
RNF111 ring finger protein 111
CDR2L cerebellar degeneration-related protein 2-like
FAM214B family with sequence similarity 214, member B
SRRM2 serine/arginine repetitive matrix 2
AURKB aurora kinase B
GRK7 G protein-coupled receptor kinase 7
TP53BP1 tumor protein p53 binding protein 1
RARA retinoic acid receptor, alpha
STIM1 stromal interaction molecule 1
CDCA2 cell division cycle associated 2
CDCA7 cell division cycle associated 7
DSP desmoplakin
CHERP calcium homeostasis endoplasmic reticulum protein
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
ATRX alpha thalassemia/mental retardation syndrome X-linked
ANKRD33B ankyrin repeat domain 33B
PRKD1 protein kinase D1
PRKD3 protein kinase D3
AURKC aurora kinase C
JMJD6 jumonji domain containing 6
POU5F1 POU class 5 homeobox 1
SETD1A SET domain containing 1A
EI24 etoposide induced 2.4
FAM207A family with sequence similarity 207, member A
NELFA negative elongation factor complex member A
TWIST1 twist family bHLH transcription factor 1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
SETD2 SET domain containing 2
NUMA1 nuclear mitotic apparatus protein 1
UBE2O ubiquitin-conjugating enzyme E2O
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
GRWD1 glutamate-rich WD repeat containing 1
CDC25A cell division cycle 25A
CLK1 CDC-like kinase 1
BAG6 BCL2-associated athanogene 6
SUN2 Sad1 and UNC84 domain containing 2
SUN1 Sad1 and UNC84 domain containing 1
SF1 splicing factor 1
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies)
CEP170 centrosomal protein 170kDa
LIMK2 LIM domain kinase 2
LIMK1 LIM domain kinase 1
DGAT1 diacylglycerol O-acyltransferase 1
LARP1 La ribonucleoprotein domain family, member 1