RORB Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description RAR-related orphan receptor B|The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014] (NCBI Entrez Gene Database, 6096)
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Genes

331 genes differentially expressed following the RORB gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CEACAM16 carcinoembryonic antigen-related cell adhesion molecule 16 3.91301
AZGP1 alpha-2-glycoprotein 1, zinc-binding 3.91301
MUC6 mucin 6, oligomeric mucus/gel-forming 3.91301
ADRB2 adrenoceptor beta 2, surface 3.91301
PGM5 phosphoglucomutase 5 3.91301
GTSF1 gametocyte specific factor 1 3.91301
FAM186A family with sequence similarity 186, member A 3.91301
GZMM granzyme M (lymphocyte met-ase 1) 3.91301
TLR3 toll-like receptor 3 3.91301
GREM2 gremlin 2, DAN family BMP antagonist 3.91301
SIM2 single-minded family bHLH transcription factor 2 3.91301
BPIFC BPI fold containing family C 3.91301
NELL1 NEL-like 1 (chicken) 3.91301
TMEM229A transmembrane protein 229A 3.91301
LGALS7B lectin, galactoside-binding, soluble, 7B 3.91301
KLHL6 kelch-like family member 6 3.91301
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 3.91301
MRPL53 mitochondrial ribosomal protein L53 3.91301
CISH cytokine inducible SH2-containing protein 3.91301
LINC02798 long intergenic non-protein coding RNA 2798 3.91301
TMC8 transmembrane channel-like 8 3.91301
LAMB4 laminin, beta 4 3.91301
PTGER3 prostaglandin E receptor 3 (subtype EP3) 3.91301
KYNU kynureninase 3.91301
ZPBP zona pellucida binding protein 3.91301
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 3.91301
KLK4 kallikrein-related peptidase 4 3.91301
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 3.91301
CCDC68 coiled-coil domain containing 68 3.88974
FOXR1 forkhead box R1 3.81535
FAM167B family with sequence similarity 167, member B 3.81535
LCN12 lipocalin 12 3.81535
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 3.81535
LRRD1 leucine-rich repeats and death domain containing 1 3.81535
TXLNB taxilin beta 3.81535
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 3.81535
RASL10A RAS-like, family 10, member A 3.81535
OR10A2 olfactory receptor, family 10, subfamily A, member 2 3.81535
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 3.81535
HLX H2.0-like homeobox 3.81535
SRL sarcalumenin 3.81535
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.81535
IGFL2 IGF-like family member 2 3.81535
GJB3 gap junction protein, beta 3, 31kDa 3.81535
PLIN4 perilipin 4 3.81535
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 3.81535
PAPOLB poly(A) polymerase beta (testis specific) 3.81535
OR1A1 olfactory receptor, family 1, subfamily A, member 1 3.81535
SP7 Sp7 transcription factor 3.81535
ANKRD34A ankyrin repeat domain 34A 3.81535
C16ORF82 chromosome 16 open reading frame 82 3.81535
SLC35G5 solute carrier family 35, member G5 3.81535
PTGFR prostaglandin F receptor (FP) 3.81535
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 3.81535
KRT27 keratin 27, type I 3.81535
SCGB3A1 secretoglobin, family 3A, member 1 3.81535
PEAR1 platelet endothelial aggregation receptor 1 3.81535
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 3.81535
SLC22A14 solute carrier family 22, member 14 3.81535
TBC1D3I TBC1 domain family member 3I 3.81535
YIPF7 Yip1 domain family, member 7 3.81535
BEND2 BEN domain containing 2 3.81535
MGAM maltase-glucoamylase 3.81535
ADGRG7 adhesion G protein-coupled receptor G7 3.81535
TCERG1L transcription elongation regulator 1-like 3.81535
PDC phosducin 3.81535
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 3.81535
PRR20G proline rich 20G 3.81535
HAO2 hydroxyacid oxidase 2 (long chain) 3.81535
MISP3 MISP family member 3 3.81535
TTLL13 tubulin tyrosine ligase like 13 3.81535
IRF2-DT IRF2 divergent transcript 3.81535
H2BK1 H2B.K variant histone 1 3.81535
LOC124906010 uncharacterized LOC124906010 3.81535
OOSP4B oocyte secreted protein family member 4B 3.81535
GLYATL1B glycine-N-acyltransferase like 1B 3.81535
CFAP299 cilia and flagella associated protein 299 3.81535
CBLIF cobalamin binding intrinsic factor 3.81535
CPHXL2 cytoplasmic polyadenylated homeobox like 2 3.81535
OR52E5 olfactory receptor, family 52, subfamily E, member 5 3.81535
ZNF705D zinc finger protein 705D 3.81535
GATA3 GATA binding protein 3 3.81535
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 3.81535
CDX1 caudal type homeobox 1 3.81535
PCDHA3 protocadherin alpha 3 3.81535
IL31RA interleukin 31 receptor A 3.81535
HHEX hematopoietically expressed homeobox 3.81535
FPR3 formyl peptide receptor 3 3.81535
ZNF99 zinc finger protein 99 3.81535
CES1 carboxylesterase 1 3.81535
PTPRH protein tyrosine phosphatase, receptor type, H 3.81535
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 3.81535
CIMAP2 ciliary microtubule associated protein 2 3.81535
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 3.81535
FAM131C family with sequence similarity 131, member C 3.81535
ABHD15 abhydrolase domain containing 15 3.81535
TACSTD2 tumor-associated calcium signal transducer 2 3.81535
LDHAL6A lactate dehydrogenase A-like 6A 3.81535
CKM creatine kinase, muscle 3.81535
CHRD chordin 3.81535
CLDN9 claudin 9 3.81535
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.81535
CRX cone-rod homeobox 3.81535
CDHR5 cadherin-related family member 5 3.81535
FADS6 fatty acid desaturase 6 3.81535
ADGRF5 adhesion G protein-coupled receptor F5 3.81535
LST1 leukocyte specific transcript 1 3.81535
VTCN1 V-set domain containing T cell activation inhibitor 1 3.81535
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 3.81535
PATE2 prostate and testis expressed 2 3.81535
GLT6D1 glycosyltransferase 6 domain containing 1 3.81535
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 3.81535
CHI3L2 chitinase 3-like 2 3.81535
LY6G5C lymphocyte antigen 6 complex, locus G5C 3.81535
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 3.81535
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.81535
RNF148 ring finger protein 148 3.81535
CFAP47 cilia and flagella associated protein 47 3.81535
IL9R interleukin 9 receptor 3.81535
EPX eosinophil peroxidase 3.81535
RBSN rabenosyn, RAB effector 3.81535
CTAGE9 CTAGE family, member 9 3.81535
ARR3 arrestin 3, retinal (X-arrestin) 3.81535
GJE1 gap junction protein, epsilon 1, 23kDa 3.81535
POF1B premature ovarian failure, 1B 3.81535
OPRK1 opioid receptor, kappa 1 3.81535
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 3.81535
C2ORF66 chromosome 2 open reading frame 66 3.81535
PLET1 placenta expressed transcript 1 3.81535
NPPA natriuretic peptide A 3.81535
CD53 CD53 molecule 3.81535
TIGIT T cell immunoreceptor with Ig and ITIM domains 3.81535
ISLR immunoglobulin superfamily containing leucine-rich repeat 3.81535
KIF4B kinesin family member 4B 3.81535
TMIGD3 transmembrane and immunoglobulin domain containing 3 3.81535
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 3.81535
CDH17 cadherin 17, LI cadherin (liver-intestine) 3.81535
GPR68 G protein-coupled receptor 68 3.81535
GPR150 G protein-coupled receptor 150 3.81535
LOC105378220 macrophage receptor MARCO-like 3.81535
LRRC43 leucine rich repeat containing 43 3.81535
OTP orthopedia homeobox 3.81535
CSNK2A3 casein kinase 2, alpha 3 polypeptide 3.81535
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.81535
C10ORF105 chromosome 10 open reading frame 105 3.81535
KLLN killin, p53-regulated DNA replication inhibitor 3.81535
MISP mitotic spindle positioning 3.81535
SFTA2 surfactant associated 2 3.81535
S100A5 S100 calcium binding protein A5 3.81535
TEX29 testis expressed 29 3.81535
ZNF831 zinc finger protein 831 3.81535
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.81535
CLCF1 cardiotrophin-like cytokine factor 1 3.81535
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.81535
TAS2R42 taste receptor, type 2, member 42 3.81535
TAS2R46 taste receptor, type 2, member 46 3.81535
HIGD2B HIG1 hypoxia inducible domain family, member 2B 3.81535
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 3.81535
ZNF648 zinc finger protein 648 3.81535
ASCL1 achaete-scute family bHLH transcription factor 1 3.81535
GSC2 goosecoid homeobox 2 3.81535
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 3.81535
ANKRD30B ankyrin repeat domain 30B 3.81535
OR13G1 olfactory receptor, family 13, subfamily G, member 1 3.81535
NOTCH4 notch 4 3.81535
ADAD2 adenosine deaminase domain containing 2 3.81535
LMAN1L lectin, mannose-binding, 1 like 3.81535
RNF43 ring finger protein 43 3.75747
SLITRK3 SLIT and NTRK-like family, member 3 3.65753
ZSCAN20 zinc finger and SCAN domain containing 20 3.65753
PDE3B phosphodiesterase 3B, cGMP-inhibited 3.24508
SZT2 seizure threshold 2 homolog (mouse) 3.14903
LYSMD1 LysM, putative peptidoglycan-binding, domain containing 1 3.06869
KIF27 kinesin family member 27 2.94005
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 2.89443
MTMR2 myotubularin related protein 2 2.81385
ECT2 epithelial cell transforming 2 2.77625
LONP1 lon peptidase 1, mitochondrial 2.69782
RIMKLB ribosomal modification protein rimK-like family member B 2.69307
EFHC2 EF-hand domain (C-terminal) containing 2 2.67866
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 2.61602
ELL3 elongation factor RNA polymerase II-like 3 2.53772
CSP2 CS pseudogene 2 2.53772
IGF1 insulin-like growth factor 1 (somatomedin C) 2.53772
LHX1 LIM homeobox 1 2.53772
FBP1 fructose-1,6-bisphosphatase 1 2.53772
GIPR gastric inhibitory polypeptide receptor 2.53772
CDC25C cell division cycle 25C 2.45204
CRACD capping protein inhibiting regulator of actin dynamics 2.44867
WDR41 WD repeat domain 41 2.43675
TMEM179 transmembrane protein 179 2.43673
RAB11FIP5 RAB11 family interacting protein 5 (class I) 2.41549
CCN1 cellular communication network factor 1 2.41549
SOCS6 suppressor of cytokine signaling 6 2.41549
KIAA0586 KIAA0586 2.39301
CAAP1 caspase activity and apoptosis inhibitor 1 2.39294
FOXA2 forkhead box A2 2.38853
BMP8A bone morphogenetic protein 8a 2.38853
CXCR2 chemokine (C-X-C motif) receptor 2 2.38853
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 2.38513
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.38144
PVRIG poliovirus receptor related immunoglobulin domain containing 2.38144
USP33 ubiquitin specific peptidase 33 2.36399
FSD1L fibronectin type III and SPRY domain containing 1-like 2.29783
REC114 REC114 meiotic recombination protein 2.23794
TFF3 trefoil factor 3 (intestinal) 2.23794
TMEM82 transmembrane protein 82 2.23794
IRAK3 interleukin-1 receptor-associated kinase 3 2.22884
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 2.21701
PI4K2B phosphatidylinositol 4-kinase type 2 beta 2.19548
FOXO3 forkhead box O3 2.17225
PKN2 protein kinase N2 2.17136
TMEM234 transmembrane protein 234 2.17136
GON4L gon-4-like (C. elegans) 2.17106
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 2.14876
TMEM120A transmembrane protein 120A 2.14876
ZBTB41 zinc finger and BTB domain containing 41 2.14381
SPRYD7 SPRY domain containing 7 2.13683
EIF4E eukaryotic translation initiation factor 4E 2.11986
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 2.11986
OLFML3 olfactomedin-like 3 2.10473
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') 2.05739
SPTSSA serine palmitoyltransferase, small subunit A 2.051
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 2.03102
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 2.02075
UCKL1 uridine-cytidine kinase 1-like 1 2.0013

decreased expression

Symbol Name Standardized Value
SOX7 SRY (sex determining region Y)-box 7 -3.91301
SYBU syntabulin (syntaxin-interacting) -3.91301
LIG4 ligase IV, DNA, ATP-dependent -3.91301
GLIPR1 GLI pathogenesis-related 1 -3.91301
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 -3.81535
MRLN myoregulin -3.81535
CD1D CD1d molecule -3.81535
RGS11 regulator of G-protein signaling 11 -3.81535
C1QTNF6 C1q and tumor necrosis factor related protein 6 -3.81535
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 -3.81535
GC group-specific component (vitamin D binding protein) -3.81535
ANGPTL7 angiopoietin-like 7 -3.81535
NLRP1 NLR family, pyrin domain containing 1 -3.81535
NOXO1 NADPH oxidase organizer 1 -3.81535
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit -3.81535
GDA guanine deaminase -3.81535
GREP1 glycine rich extracellular protein 1 -3.81535
DLX4 distal-less homeobox 4 -3.81535
SOST sclerostin -3.81535
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 -3.81535
R3HDML R3H domain containing-like -3.81535
KLF5 Kruppel-like factor 5 (intestinal) -3.81535
NPFFR1 neuropeptide FF receptor 1 -3.81535
NR5A1 nuclear receptor subfamily 5, group A, member 1 -3.81535
KLK14 kallikrein-related peptidase 14 -3.81535
ETV3L ets variant 3-like -3.81535
RUMY3 RUMY family member 3 -3.81535
STYXL2 serine/threonine/tyrosine interacting like 2 -3.81535
MUC19 mucin 19, oligomeric -3.81535
RTL5 retrotransposon Gag like 5 -3.81535
PRPH2 peripherin 2 (retinal degeneration, slow) -3.81535
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) -3.81535
CDH12 cadherin 12, type 2 (N-cadherin 2) -3.81535
SPATS1 spermatogenesis associated, serine-rich 1 -3.81535
SDK2 sidekick cell adhesion molecule 2 -3.41892
SV2A synaptic vesicle glycoprotein 2A -3.23887
LRRC49 leucine rich repeat containing 49 -3.01099
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 -2.99629
RHCE Rh blood group, CcEe antigens -2.95517
HRH3 histamine receptor H3 -2.95517
ZNF324B zinc finger protein 324B -2.95517
TMEM190 transmembrane protein 190 -2.95517
ACSL6 acyl-CoA synthetase long-chain family member 6 -2.95517
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma -2.95517
A4GALT alpha 1,4-galactosyltransferase -2.93825
RPL13 ribosomal protein L13 -2.86011
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -2.82105
FSBP fibrinogen silencer binding protein -2.80218
GSDME gasdermin E -2.79727
TPRKB TP53RK binding protein -2.75599
NOS1 nitric oxide synthase 1 (neuronal) -2.70534
DCTD dCMP deaminase -2.64287
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -2.62923
ZSCAN26 zinc finger and SCAN domain containing 26 -2.62653
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.62305
PVALB parvalbumin -2.5415
TECPR2 tectonin beta-propeller repeat containing 2 -2.5262
EFNA2 ephrin-A2 -2.52602
GPR82 G protein-coupled receptor 82 -2.50234
SYNDIG1L synapse differentiation inducing 1-like -2.47839
MYT1 myelin transcription factor 1 -2.47839
CFL1 cofilin 1 (non-muscle) -2.47646
CCDC74B coiled-coil domain containing 74B -2.47546
CPEB1 cytoplasmic polyadenylation element binding protein 1 -2.47208
HSPA13 heat shock protein 70kDa family, member 13 -2.45174
VSTM2B V-set and transmembrane domain containing 2B -2.44897
C5 complement component 5 -2.44264
ZBTB16 zinc finger and BTB domain containing 16 -2.44264
CST6 cystatin E/M -2.44264
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 -2.43751
NTN4 netrin 4 -2.41549
FBL fibrillarin -2.39154
UBE2N ubiquitin-conjugating enzyme E2N -2.38853
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -2.38144
ZNF385B zinc finger protein 385B -2.37636
TRMO tRNA methyltransferase O -2.37514
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) -2.35907
BAG1 BCL2-associated athanogene -2.3559
RANBP1 RAN binding protein 1 -2.3559
CTSZ cathepsin Z -2.33741
ZNF527 zinc finger protein 527 -2.33655
PRIMA1 proline rich membrane anchor 1 -2.27193
TTI1 TELO2 interacting protein 1 -2.2471
TPI1 triosephosphate isomerase 1 -2.23164
PABPN1 poly(A) binding protein, nuclear 1 -2.23164
KIF3B kinesin family member 3B -2.22797
EXOSC3 exosome component 3 -2.22044
RHBDL2 rhomboid, veinlet-like 2 (Drosophila) -2.2072
TMEM101 transmembrane protein 101 -2.14924
TMEM117 transmembrane protein 117 -2.14876
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) -2.14876
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 -2.14876
ZNF76 zinc finger protein 76 -2.13683
PEX10 peroxisomal biogenesis factor 10 -2.13683
MBD4 methyl-CpG binding domain protein 4 -2.13683
SFRP2 secreted frizzled-related protein 2 -2.13487
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -2.12176
CRABP2 cellular retinoic acid binding protein 2 -2.11402
MCC mutated in colorectal cancers -2.04178
PHTF2 putative homeodomain transcription factor 2 -2.03296
DMPK dystrophia myotonica-protein kinase -2.03296
COPA coatomer protein complex, subunit alpha -2.03102
SCAND1 SCAN domain containing 1 -2.01065
EML2 echinoderm microtubule associated protein like 2 -2.00889
FAM219B family with sequence similarity 219, member B -2.00305