RPIA Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ribose 5-phosphate isomerase A|The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18. [provided by RefSeq, Mar 2010] (NCBI Entrez Gene Database, 22934)
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Genes

300 genes differentially expressed following the RPIA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
MUC13 mucin 13, cell surface associated 3.01841
PCDHGB4 protocadherin gamma subfamily B, 4 3.01841
DSG3 desmoglein 3 3.01841
POF1B premature ovarian failure, 1B 3.01841
TMEM132E transmembrane protein 132E 3.01841
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 3.01841
ERICH6 glutamate-rich 6 3.01841
SCNN1G sodium channel, non voltage gated 1 gamma subunit 3.01841
SPINK4 serine peptidase inhibitor, Kazal type 4 3.01841
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 3.01841
GNG8 guanine nucleotide binding protein (G protein), gamma 8 3.01841
ACTL8 actin-like 8 3.01841
ERVFRD-1 endogenous retrovirus group FRD, member 1 3.01841
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 3.01841
TLDC2 TBC/LysM-associated domain containing 2 3.01841
LRRIQ3 leucine-rich repeats and IQ motif containing 3 3.01841
LBHD1 LBH domain containing 1 3.01841
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 3.01841
TTLL12 tubulin tyrosine ligase-like family member 12 3.01767
ASB12 ankyrin repeat and SOCS box containing 12 2.93882
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.93882
XAF1 XIAP associated factor 1 2.93882
LIPH lipase, member H 2.93882
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.93882
NPAP1 nuclear pore associated protein 1 2.93882
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 2.93882
NR1H4 nuclear receptor subfamily 1, group H, member 4 2.93882
LY86 lymphocyte antigen 86 2.93882
CST11 cystatin 11 2.93882
PKP1 plakophilin 1 2.93882
TMEM151A transmembrane protein 151A 2.93882
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.93882
PCDH8 protocadherin 8 2.93882
TMEM72 transmembrane protein 72 2.93882
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.93882
LRRIQ4 leucine-rich repeats and IQ motif containing 4 2.93882
NPIPA3 nuclear pore complex interacting protein family, member A3 2.93882
RFX6 regulatory factor X, 6 2.93882
MPL MPL proto-oncogene, thrombopoietin receptor 2.93882
HAS1 hyaluronan synthase 1 2.93882
THRSP thyroid hormone responsive 2.93882
ARSF arylsulfatase F 2.93882
PGBDF plakoglobin binding and degradation factor 2.93882
UNC13C unc-13 homolog C (C. elegans) 2.93882
GSTM5 glutathione S-transferase mu 5 2.93882
OR2J2 olfactory receptor, family 2, subfamily J, member 2 2.93882
PAX1 paired box 1 2.93882
DMRTC1B DMRT-like family C1B 2.93882
OLIG2 oligodendrocyte lineage transcription factor 2 2.93882
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 2.93882
BMP5 bone morphogenetic protein 5 2.93882
HRH4 histamine receptor H4 2.93882
CCDC116 coiled-coil domain containing 116 2.93882
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.93882
SPRR2A small proline-rich protein 2A 2.93882
KRT80 keratin 80, type II 2.93882
MGAT4D MGAT4 family, member D 2.93882
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 2.93882
GBP4 guanylate binding protein 4 2.93882
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 2.93882
VSIR V-set immunoregulatory receptor 2.93882
H3-5 H3.5 histone 2.93882
ALPG alkaline phosphatase, germ cell 2.93882
LORICRIN loricrin cornified envelope precursor protein 2.93882
CFAP141 cilia and flagella associated protein 141 2.93882
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.93882
H2BW2 H2B.W histone 2 2.93882
ARMH2 armadillo like helical domain containing 2 2.93882
EZHIP EZH inhibitory protein 2.93882
TMDD1 transmembrane and death domain 1 2.93882
TMPRSS4 transmembrane protease, serine 4 2.93882
MIOX myo-inositol oxygenase 2.93882
IMPG2 interphotoreceptor matrix proteoglycan 2 2.93882
TPBGL trophoblast glycoprotein-like 2.93882
IZUMO4 IZUMO family member 4 2.93882
TRIM67 tripartite motif containing 67 2.93882
FOXD1 forkhead box D1 2.93882
CAPN14 calpain 14 2.93882
CAPN11 calpain 11 2.93882
KLHL33 kelch-like family member 33 2.93882
PTGDR2 prostaglandin D2 receptor 2 2.93882
TSGA10IP testis specific, 10 interacting protein 2.93882
CD79A CD79a molecule, immunoglobulin-associated alpha 2.93882
OVOL1 ovo-like zinc finger 1 2.93882
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.93882
MTMR11 myotubularin related protein 11 2.93882
OOSP1 oocyte secreted protein 1, pseudogene 2.93882
TAS1R1 taste receptor, type 1, member 1 2.93882
LRRC73 leucine rich repeat containing 73 2.93882
PARVG parvin, gamma 2.93882
LITAFD LITAF domain containing 2.93882
MS4A8 membrane-spanning 4-domains, subfamily A, member 8 2.93882
BCL2L15 BCL2-like 15 2.93882
TBC1D26 TBC1 domain family, member 26 2.93882
ANKRD33 ankyrin repeat domain 33 2.93882
PLGLB2 plasminogen-like B2 2.93882
NUTM2F NUT family member 2F 2.93882
EPO erythropoietin 2.93882
TMPPE transmembrane protein with metallophosphoesterase domain 2.93882
ADGRF4 adhesion G protein-coupled receptor F4 2.93882
ROM1 retinal outer segment membrane protein 1 2.93882
ORM2 orosomucoid 2 2.93882
POTEF POTE ankyrin domain family, member F 2.93882
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.93882
OR56B4 olfactory receptor, family 56, subfamily B, member 4 2.93882
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.93882
ST18 suppression of tumorigenicity 18, zinc finger 2.93882
HIGD2B HIG1 hypoxia inducible domain family, member 2B 2.93882
CA5A carbonic anhydrase VA, mitochondrial 2.93882
DMRT2 doublesex and mab-3 related transcription factor 2 2.93882
BCL2A1 BCL2-related protein A1 2.93882
LMOD2 leiomodin 2 (cardiac) 2.93882
EVPLL envoplakin-like 2.93882
CRHR1 corticotropin releasing hormone receptor 1 2.93882
CGB7 chorionic gonadotropin, beta polypeptide 7 2.93882
PLA1A phospholipase A1 member A 2.93882
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.93882
HPX hemopexin 2.93882
KLF1 Kruppel-like factor 1 (erythroid) 2.93882
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.93882
BTNL3 butyrophilin-like 3 2.93882
NXNL1 nucleoredoxin-like 1 2.93882
MARCKS myristoylated alanine-rich protein kinase C substrate 2.93882
FAIM2 Fas apoptotic inhibitory molecule 2 2.93882
OR3A1 olfactory receptor, family 3, subfamily A, member 1 2.93882
KCNK16 potassium channel, two pore domain subfamily K, member 16 2.93882
NLRP14 NLR family, pyrin domain containing 14 2.93882
ANXA2R annexin A2 receptor 2.93882
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 2.93882
FAM151A family with sequence similarity 151, member A 2.93882
TMEM255A transmembrane protein 255A 2.93882
NR2F1 nuclear receptor subfamily 2, group F, member 1 2.93882
FAM81B family with sequence similarity 81, member B 2.93882
ETV3L ets variant 3-like 2.93882
FKBP1C FK506 binding protein 1C 2.93882
PRSS21 protease, serine, 21 (testisin) 2.93882
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.93882
RNASE9 ribonuclease, RNase A family, 9 (non-active) 2.93882
DNAH2 dynein, axonemal, heavy chain 2 2.93882
EOMES eomesodermin 2.93882
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.93882
PRDM8 PR domain containing 8 2.93882
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.93882
CD22 CD22 molecule 2.93882
ERVV-1 endogenous retrovirus group V, member 1 2.93882
DEFB136 defensin, beta 136 2.93882
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.93882
GPR17 G protein-coupled receptor 17 2.93882
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2.93882
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) 2.93882
IL37 interleukin 37 2.93882
NLRP3 NLR family, pyrin domain containing 3 2.93882
ANKRD30B ankyrin repeat domain 30B 2.93882
BOD1L2 biorientation of chromosomes in cell division 1-like 2 2.93882
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.93882
COL8A1 collagen, type VIII, alpha 1 2.86206
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) 2.83843
TNMD tenomodulin 2.77388
EPOP elongin BC and polycomb repressive complex 2 associated protein 2.76819
LMNTD2 lamin tail domain containing 2 2.76819
THEM6 thioesterase superfamily member 6 2.76819
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 2.72503
MRPL9 mitochondrial ribosomal protein L9 2.71371
CEP112 centrosomal protein 112kDa 2.66821
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 2.63341
MUL1 mitochondrial E3 ubiquitin protein ligase 1 2.59327
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 2.55752
ZNF749 zinc finger protein 749 2.55491
SELENOH selenoprotein H 2.49256
TBXAS1 thromboxane A synthase 1 (platelet) 2.46554
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) 2.46097
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) 2.4546
ATP5F1E ATP synthase F1 subunit epsilon 2.4384
SPATS1 spermatogenesis associated, serine-rich 1 2.4269
OLFM2 olfactomedin 2 2.4269
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 2.4269
CD177 CD177 molecule 2.4269
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2.40878
CELA2B chymotrypsin-like elastase family, member 2B 2.36663
CLEC16A C-type lectin domain family 16, member A 2.35565
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 2.29861
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) 2.27423
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 2.26925
GGACT gamma-glutamylamine cyclotransferase 2.25274
ANKRD42-DT ANKRD42 divergent transcript 2.25274
SORBS2 sorbin and SH3 domain containing 2 2.2393
SENP5 SUMO1/sentrin specific peptidase 5 2.20464
MAPRE2 microtubule-associated protein, RP/EB family, member 2 2.20144
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) 2.1875
HENMT1 HEN1 methyltransferase homolog 1 (Arabidopsis) 2.187
SOCS3 suppressor of cytokine signaling 3 2.18146
SLC35H1 solute carrier family 35 member H1 2.18146
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 2.13204
SMAD4 SMAD family member 4 2.12331
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 2.12329
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 2.12252
ERC1 ELKS/RAB6-interacting/CAST family member 1 2.08687
TMCC3 transmembrane and coiled-coil domain family 3 2.08081
PFDN4 prefoldin subunit 4 2.08081
ANO3 anoctamin 3 2.07653
ATRAID all-trans retinoic acid-induced differentiation factor 2.05757
FKBP1B FK506 binding protein 1B, 12.6 kDa 2.05724
KANK2 KN motif and ankyrin repeat domains 2 2.04268
ZNF551 zinc finger protein 551 2.03976
INAFM2 InaF-motif containing 2 2.03011
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 2.02009
SMS spermine synthase 2.01687

decreased expression

Symbol Name Standardized Value
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) -3.01841
SCT secretin -3.01841
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -3.01841
RPIA ribose 5-phosphate isomerase A -3.01841
OVCH2 ovochymase 2 (gene/pseudogene) -3.01841
RASD2 RASD family, member 2 -3.01841
ARHGAP30 Rho GTPase activating protein 30 -3.01841
ZNF165 zinc finger protein 165 -3.01767
SNORC secondary ossification center associated regulator of chondrocyte maturation -2.9783
TEX101 testis expressed 101 -2.93882
PTGDS prostaglandin D2 synthase 21kDa (brain) -2.93882
H4C12 H4 clustered histone 12 -2.93882
JUN jun proto-oncogene -2.93882
CD86 CD86 molecule -2.93882
CD300A CD300a molecule -2.93882
AHSG alpha-2-HS-glycoprotein -2.93882
APLN apelin -2.93882
CXXC1 CXXC finger protein 1 -2.93882
PCDHGA7 protocadherin gamma subfamily A, 7 -2.93882
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha -2.93882
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 -2.93882
C9ORF152 chromosome 9 open reading frame 152 -2.93882
TGFBR1 transforming growth factor, beta receptor 1 -2.93882
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -2.93882
RHOXF2 Rhox homeobox family, member 2 -2.93882
COL11A2 collagen, type XI, alpha 2 -2.93882
ZNF575 zinc finger protein 575 -2.93882
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) -2.93882
SCNN1D sodium channel, non voltage gated 1 delta subunit -2.93882
COPS6 COP9 signalosome subunit 6 -2.93882
TEX12 testis expressed 12 -2.93882
FOXN4 forkhead box N4 -2.93882
ACSL6 acyl-CoA synthetase long-chain family member 6 -2.93882
PCDHGA4 protocadherin gamma subfamily A, 4 -2.93882
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A -2.93882
LGSN lengsin, lens protein with glutamine synthetase domain -2.93882
TRIM54 tripartite motif containing 54 -2.93882
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -2.93882
ANKRD61 ankyrin repeat domain 61 -2.93882
RPS20 ribosomal protein S20 -2.85671
EP400 E1A binding protein p400 -2.78674
DAAM1 dishevelled associated activator of morphogenesis 1 -2.72934
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 -2.66491
NDRG4 NDRG family member 4 -2.59422
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 -2.59413
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) -2.5903
IQCJ IQ motif containing J -2.55491
SHISAL2A shisa like 2A -2.55491
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 -2.55491
H2BC5 H2B clustered histone 5 -2.55387
JOSD2 Josephin domain containing 2 -2.49389
IGSF1 immunoglobulin superfamily, member 1 -2.48552
MEGF9 multiple EGF-like-domains 9 -2.46097
PPARD peroxisome proliferator-activated receptor delta -2.45528
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -2.45033
FCGBP Fc fragment of IgG binding protein -2.41151
GOSR2 golgi SNAP receptor complex member 2 -2.40693
BTBD10 BTB (POZ) domain containing 10 -2.38535
LIME1 Lck interacting transmembrane adaptor 1 -2.38535
CCDC74B coiled-coil domain containing 74B -2.38535
TMEM100 transmembrane protein 100 -2.38535
CBLN1 cerebellin 1 precursor -2.38535
CLNK cytokine-dependent hematopoietic cell linker -2.32675
DNAJC19 DnaJ (Hsp40) homolog, subfamily C, member 19 -2.28929
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough -2.27423
TENT4B terminal nucleotidyltransferase 4B -2.25323
SDR42E2 short chain dehydrogenase/reductase family 42E, member 2 -2.24672
PHIP pleckstrin homology domain interacting protein -2.20622
BST1 bone marrow stromal cell antigen 1 -2.20294
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 -2.20294
TMED1 transmembrane emp24 protein transport domain containing 1 -2.17076
PLPPR1 phospholipid phosphatase related 1 -2.16331
FOSL1 FOS-like antigen 1 -2.13877
CRABP2 cellular retinoic acid binding protein 2 -2.13702
MSN moesin -2.13702
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -2.12932
ROMO1 reactive oxygen species modulator 1 -2.12331
ZNF26 zinc finger protein 26 -2.12252
REC8 REC8 meiotic recombination protein -2.11141
SURF6 surfeit 6 -2.09984
SNAI1 snail family zinc finger 1 -2.0893
MROH7 maestro heat-like repeat family member 7 -2.0893
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.0893
NSMCE1 non-SMC element 1 homolog (S. cerevisiae) -2.08892
HBS1L HBS1-like translational GTPase -2.08892
PLXND1 plexin D1 -2.0623
ERRFI1 ERBB receptor feedback inhibitor 1 -2.05724
BEND6 BEN domain containing 6 -2.05493
SCFD1 sec1 family domain containing 1 -2.04671
ADRA2B adrenoceptor alpha 2B -2.04079
RIPOR1 RHO family interacting cell polarization regulator 1 -2.04079
MYOM1 myomesin 1 -2.03976
SCTR secretin receptor -2.00822