RPL5 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description ribosomal protein L5|Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18P family of ribosomal proteins. It is located in the cytoplasm. The protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The protein interacts specifically with the beta subunit of casein kinase II. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6125)
External Link http://www.ncbi.nlm.nih.gov/gene/6125
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Genes

112 interacting proteins for hub protein RPL5 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACSL5 acyl-CoA synthetase long-chain family member 5
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CD40LG CD40 ligand
CDC16 cell division cycle 16
CNOT3 CCR4-NOT transcription complex, subunit 3
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2B casein kinase 2, beta polypeptide
CYLD cylindromatosis (turban tumor syndrome)
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DCC DCC netrin 1 receptor
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DKC1 dyskeratosis congenita 1, dyskerin
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21
ECM1 extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
ESR1 estrogen receptor 1
FMR1 fragile X mental retardation 1
GABARAP GABA(A) receptor-associated protein
GABARAPL1 GABA(A) receptor-associated protein like 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2
GRP gastrin-releasing peptide
GTPBP4 GTP binding protein 4
HARS histidyl-tRNA synthetase
HMGB2 high mobility group box 2
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
INO80 INO80 complex subunit
IPO13 importin 13
IPO5 importin 5
IPO7 importin 7
JAG2 jagged 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KIAA0020 KIAA0020
KPNB1 karyopherin (importin) beta 1
KRI1 KRI1 homolog (S. cerevisiae)
LSG1 large 60S subunit nuclear export GTPase 1
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MBD5 methyl-CpG binding domain protein 5
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MORF4L1 mortality factor 4 like 1
MRPL22 mitochondrial ribosomal protein L22
MYO5A myosin VA (heavy chain 12, myoxin)
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit
NABP1 nucleic acid binding protein 1
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NHP2 NHP2 ribonucleoprotein
NIP7 NIP7, nucleolar pre-rRNA processing protein
NMD3 NMD3 ribosome export adaptor
NOP2 NOP2 nucleolar protein
NOP58 NOP58 ribonucleoprotein
NPR1 natriuretic peptide receptor 1
NVL nuclear VCP-like
PDCD11 programmed cell death 11
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PITX2 paired-like homeodomain 2
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPAN peter pan homolog (Drosophila)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PUS1 pseudouridylate synthase 1
PWP1 PWP1 homolog (S. cerevisiae)
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RB1 retinoblastoma 1
RPF1 ribosome production factor 1 homolog (S. cerevisiae)
RPF2 ribosome production factor 2 homolog (S. cerevisiae)
RPH3AL rabphilin 3A-like (without C2 domains)
RPL11 ribosomal protein L11
RPL18A ribosomal protein L18a
RPL23 ribosomal protein L23
RPL23A ribosomal protein L23a
RPL5 ribosomal protein L5
RPN1 ribophorin I
RPS23 ribosomal protein S23
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAE1 SUMO1 activating enzyme subunit 1
SCARF2 scavenger receptor class F, member 2
SETD2 SET domain containing 2
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SMC3 structural maintenance of chromosomes 3
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SYS1 Sys1 golgi trafficking protein
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TEX10 testis expressed 10
TNIP1 TNFAIP3 interacting protein 1
TNPO1 transportin 1
TP53 tumor protein p53
TRAPPC3 trafficking protein particle complex 3
TRMT61A tRNA methyltransferase 61A
TTC37 tetratricopeptide repeat domain 37
UBP1 upstream binding protein 1 (LBP-1a)
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
UTP15 UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)
UTP23 UTP23, small subunit (SSU) processome component, homolog (yeast)
VTA1 vesicle (multivesicular body) trafficking 1
WDR12 WD repeat domain 12
XPO6 exportin 6
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF410 zinc finger protein 410
ZNRD1 zinc ribbon domain containing 1