RPS14_DN.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/RPS14_DN.V1_UP
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378 genes differentially expressed following the RPS14_DN.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADA adenosine deaminase
ADAMDEC1 ADAM-like, decysin 1
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6
ADRA2A adrenoceptor alpha 2A
AIF1 allograft inflammatory factor 1
ALCAM activated leukocyte cell adhesion molecule
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
ANPEP alanyl (membrane) aminopeptidase
ANXA3 annexin A3
ANXA6 annexin A6
ARHGAP25 Rho GTPase activating protein 25
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4C ADP-ribosylation factor-like 4C
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATP8B4 ATPase, class I, type 8B, member 4
AZU1 azurocidin 1
BCL2A1 BCL2-related protein A1
BCL6 B-cell CLL/lymphoma 6
BIRC3 baculoviral IAP repeat containing 3
BST1 bone marrow stromal cell antigen 1
C3AR1 complement component 3a receptor 1
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CALB1 calbindin 1, 28kDa
CAPG capping protein (actin filament), gelsolin-like
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL1 chemokine (C-C motif) ligand 1
CCL2 chemokine (C-C motif) ligand 2
CCNA1 cyclin A1
CD14 CD14 molecule
CD300A CD300a molecule
CD69 CD69 molecule
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDCP1 CUB domain containing protein 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CECR1 cat eye syndrome chromosome region, candidate 1
CELA2A chymotrypsin-like elastase family, member 2A
CLEC2B C-type lectin domain family 2, member B
CLEC5A C-type lectin domain family 5, member A
CLEC7A C-type lectin domain family 7, member A
COLEC12 collectin sub-family member 12
CPM carboxypeptidase M
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CROT carnitine O-octanoyltransferase
CRTAM cytotoxic and regulatory T cell molecule
CSTA cystatin A (stefin A)
CTSG cathepsin G
CTSH cathepsin H
CTSS cathepsin S
CXCL8 chemokine (C-X-C motif) ligand 8
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYSLTR1 cysteinyl leukotriene receptor 1
DCN decorin
DMXL2 Dmx-like 2
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
EGR3 early growth response 3
ELANE elastase, neutrophil expressed
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPS8L2 EPS8-like 2
EVI2A ecotropic viral integration site 2A
EVI2B ecotropic viral integration site 2B
F13A1 coagulation factor XIII, A1 polypeptide
F5 coagulation factor V (proaccelerin, labile factor)
FBN2 fibrillin 2
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FRY furry homolog (Drosophila)
FUCA1 fucosidase, alpha-L- 1, tissue
GDF15 growth differentiation factor 15
GFI1 growth factor independent 1 transcription repressor
GJA1 gap junction protein, alpha 1, 43kDa
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB5 guanine nucleotide binding protein (G protein), beta 5
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPR183 G protein-coupled receptor 183
HCK HCK proto-oncogene, Src family tyrosine kinase
HESX1 HESX homeobox 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLA-DRB6 major histocompatibility complex, class II, DR beta 6 (pseudogene)
ICAM3 intercellular adhesion molecule 3
IFI16 interferon, gamma-inducible protein 16
IGFBP7 insulin-like growth factor binding protein 7
IGSF6 immunoglobulin superfamily, member 6
IL1B interleukin 1, beta
IL1RAP interleukin 1 receptor accessory protein
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAG1 jagged 1
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCTD12 potassium channel tetramerization domain containing 12
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KYNU kynureninase
LECT2 leukocyte cell-derived chemotaxin 2
LINC00461 long intergenic non-protein coding RNA 461
LPXN leupaxin
LST1 leukocyte specific transcript 1
LY75 lymphocyte antigen 75
LY86 lymphocyte antigen 86
LY96 lymphocyte antigen 96
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MARCKS myristoylated alanine-rich protein kinase C substrate
MDFIC MyoD family inhibitor domain containing
MNDA myeloid cell nuclear differentiation antigen
MPL MPL proto-oncogene, thrombopoietin receptor
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MYO1F myosin IF
NCF2 neutrophil cytosolic factor 2
NKG7 natural killer cell granule protein 7
NR4A3 nuclear receptor subfamily 4, group A, member 3
NYNRIN NYN domain and retroviral integrase containing
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PADI2 peptidyl arginine deiminase, type II
PDE4D phosphodiesterase 4D, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PF4V1 platelet factor 4 variant 1
PID1 phosphotyrosine interaction domain containing 1
PILRA paired immunoglobin-like type 2 receptor alpha
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PMP2 peripheral myelin protein 2
POM121L9P POM121 transmembrane nucleoporin-like 9, pseudogene
PRG3 proteoglycan 3
PROM1 prominin 1
PRTN3 proteinase 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRE protein tyrosine phosphatase, receptor type, E
PTPRG protein tyrosine phosphatase, receptor type, G
PTPRO protein tyrosine phosphatase, receptor type, O
PYCARD PYD and CARD domain containing
RAB31 RAB31, member RAS oncogene family
RASAL2 RAS protein activator like 2
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RBM47 RNA binding motif protein 47
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RHOB ras homolog family member B
RIN2 Ras and Rab interactor 2
RMST rhabdomyosarcoma 2 associated transcript (non-protein coding)
SASH3 SAM and SH3 domain containing 3
SCN3A sodium channel, voltage gated, type III alpha subunit
SDC4 syndecan 4
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
SEPT10 septin 10
SESN1 sestrin 1
SFXN3 sideroflexin 3
SH2D2A SH2 domain containing 2A
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SH3GL3 SH3-domain GRB2-like 3
SIRPA signal-regulatory protein alpha
SLAMF8 SLAM family member 8
SLC31A2 solute carrier family 31 (copper transporter), member 2
SMAD3 SMAD family member 3
SNTG1 syntrophin, gamma 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK4 serine peptidase inhibitor, Kazal type 4
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPP1 secreted phosphoprotein 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STX3 syntaxin 3
TAC3 tachykinin 3
TFEC transcription factor EC
TGFBI transforming growth factor, beta-induced, 68kDa
TIGAR TP53 induced glycolysis regulatory phosphatase
TM6SF1 transmembrane 6 superfamily member 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TRIM22 tripartite motif containing 22
TRIM36 tripartite motif containing 36
TYROBP TYRO protein tyrosine kinase binding protein
VNN1 vanin 1
VWF von Willebrand factor
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ADD2 adducin 2 (beta)
ADGRA3 adhesion G protein-coupled receptor A3
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AGFG2 ArfGAP with FG repeats 2
ALAD aminolevulinate dehydratase
AOC2 amine oxidase, copper containing 2 (retina-specific)
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
APOOL apolipoprotein O-like
ARHGAP11A Rho GTPase activating protein 11A
ART4 ADP-ribosyltransferase 4 (Dombrock blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATAD2 ATPase family, AAA domain containing 2
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BYSL bystin-like
C10ORF2 chromosome 10 open reading frame 2
C14ORF132 chromosome 14 open reading frame 132
CA3 carbonic anhydrase III
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CBS cystathionine-beta-synthase
CCNB2 cyclin B2
CD320 CD320 molecule
CDC20 cell division cycle 20
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDR2 cerebellar degeneration-related protein 2, 62kDa
CENPE centromere protein E, 312kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CLCN4 chloride channel, voltage-sensitive 4
CNN3 calponin 3, acidic
COBLL1 cordon-bleu WH2 repeat protein-like 1
COLEC11 collectin sub-family member 11
CRISP2 cysteine-rich secretory protein 2
CRMP1 collapsin response mediator protein 1
CYBRD1 cytochrome b reductase 1
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DDN dendrin
DEPDC1 DEP domain containing 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DOCK9 dedicator of cytokinesis 9
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
E2F8 E2F transcription factor 8
ECT2 epithelial cell transforming 2
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
ELMO3 engulfment and cell motility 3
EMP2 epithelial membrane protein 2
ENG endoglin
EPB41 erythrocyte membrane protein band 4.1
EPCAM epithelial cell adhesion molecule
ERCC2 excision repair cross-complementation group 2
ERCC6L excision repair cross-complementation group 6-like
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FBXO5 F-box protein 5
FICD FIC domain containing
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FZD5 frizzled class receptor 5
GAL galanin/GMAP prepropeptide
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GCDH glutaryl-CoA dehydrogenase
GEMIN4 gem (nuclear organelle) associated protein 4
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLRA2 glycine receptor, alpha 2
GPATCH4 G patch domain containing 4
GSTA4 glutathione S-transferase alpha 4
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HGH1 HGH1 homolog (S. cerevisiae)
HMGN5 high mobility group nucleosome binding domain 5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL15RA interleukin 15 receptor, alpha
IL7 interleukin 7
INCENP inner centromere protein antigens 135/155kDa
IPO4 importin 4
ISOC2 isochorismatase domain containing 2
KANK2 KN motif and ankyrin repeat domains 2
KCTD20 potassium channel tetramerization domain containing 20
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF5A kinesin family member 5A
KLHL7 kelch-like family member 7
KRT13 keratin 13, type I
LARS2 leucyl-tRNA synthetase 2, mitochondrial
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOC730101 uncharacterized LOC730101
LRRC20 leucine rich repeat containing 20
MACROD1 MACRO domain containing 1
MAMLD1 mastermind-like domain containing 1
MANEA mannosidase, endo-alpha
MCM10 minichromosome maintenance complex component 10
MCM5 minichromosome maintenance complex component 5
MDM4 MDM4, p53 regulator
MIPEP mitochondrial intermediate peptidase
MKI67 marker of proliferation Ki-67
MRPL12 mitochondrial ribosomal protein L12
MRPS2 mitochondrial ribosomal protein S2
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSH2 mutS homolog 2
MTPAP mitochondrial poly(A) polymerase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYH10 myosin, heavy chain 10, non-muscle
MYLIP myosin regulatory light chain interacting protein
MYO19 myosin XIX
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NCAPH non-SMC condensin I complex, subunit H
NDC1 NDC1 transmembrane nucleoporin
NEFH neurofilament, heavy polypeptide
NID2 nidogen 2 (osteonidogen)
NLE1 notchless homolog 1 (Drosophila)
NMU neuromedin U
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NUP155 nucleoporin 155kDa
ORC1 origin recognition complex, subunit 1
PBK PDZ binding kinase
PC pyruvate carboxylase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCOLCE procollagen C-endopeptidase enhancer
PCSK7 proprotein convertase subtilisin/kexin type 7
PES1 pescadillo ribosomal biogenesis factor 1
PKLR pyruvate kinase, liver and RBC
PLK1 polo-like kinase 1
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PRC1 protein regulator of cytokinesis 1
PRMT3 protein arginine methyltransferase 3
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RAP1GAP RAP1 GTPase activating protein
RASIP1 Ras interacting protein 1
REPS2 RALBP1 associated Eps domain containing 2
RGS5 regulator of G-protein signaling 5
RPS28 ribosomal protein S28
RPUSD2 RNA pseudouridylate synthase domain containing 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A3 S100 calcium binding protein A3
SERHL serine hydrolase-like (pseudogene)
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIRT4 sirtuin 4
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPHK1 sphingosine kinase 1
SPTB spectrin, beta, erythrocytic
SRD5A3 steroid 5 alpha-reductase 3
SRM spermidine synthase
SRR serine racemase
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STEAP3 STEAP family member 3, metalloreductase
STMN2 stathmin 2
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TBRG4 transforming growth factor beta regulator 4
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGM2 transglutaminase 2
THEM6 thioesterase superfamily member 6
TK1 thymidine kinase 1, soluble
TLN2 talin 2
TLX2 T-cell leukemia homeobox 2
TMSB15A thymosin beta 15a
TPRA1 transmembrane protein, adipocyte asscociated 1
TRIM29 tripartite motif containing 29
TRIP13 thyroid hormone receptor interactor 13
TSPO2 translocator protein 2
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBG1 tubulin, gamma 1
TUBGCP4 tubulin, gamma complex associated protein 4
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VARS valyl-tRNA synthetase
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF74 zinc finger protein 74
ZNHIT2 zinc finger, HIT-type containing 2
ZWILCH zwilch kinetochore protein