RPS6KA1 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description ribosomal protein S6 kinase, 90kDa, polypeptide 1|This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6195)
External Link http://www.ncbi.nlm.nih.gov/gene/6195
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45 substrates of the kinase RPS6KA1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
APAF1 apoptotic peptidase activating factor 1
BAD BCL2-associated agonist of cell death
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CIC capicua transcriptional repressor
CREB1 cAMP responsive element binding protein 1
DAPK1 death-associated protein kinase 1
DEPTOR DEP domain containing MTOR-interacting protein
EEF2K eukaryotic elongation factor 2 kinase
EIF4B eukaryotic translation initiation factor 4B
ESR1 estrogen receptor 1
FLNA filamin A, alpha
FOS FBJ murine osteosarcoma viral oncogene homolog
GAB2 GRB2-associated binding protein 2
GMFB glia maturation factor, beta
GSK3B glycogen synthase kinase 3 beta
H3F3B H3 histone, family 3B (H3.3B)
HMGN1 high mobility group nucleosome binding domain 1
ITGB4 integrin, beta 4
KRT17 keratin 17, type I
MAPK7 mitogen-activated protein kinase 7
METTL1 methyltransferase like 1
MITF microphthalmia-associated transcription factor
MXD1 MAX dimerization protein 1
NDRG2 NDRG family member 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
OSTF1 osteoclast stimulating factor 1
RANBP3 RAN binding protein 3
RPS6 ribosomal protein S6
RPTOR regulatory associated protein of MTOR, complex 1
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SOS1 son of sevenless homolog 1 (Drosophila)
SRF serum response factor (c-fos serum response element-binding transcription factor)
STK11 serine/threonine kinase 11
TNNI3 troponin I type 3 (cardiac)
TSC2 tuberous sclerosis 2
VASP vasodilator-stimulated phosphoprotein
WWC1 WW and C2 domain containing 1
YBX1 Y box binding protein 1