RPS6KA3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ribosomal protein S6 kinase, 90kDa, polypeptide 3|This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6197)
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Genes

332 genes differentially expressed following the RPS6KA3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GPR25 G protein-coupled receptor 25 4.02518
LACTBL1 lactamase, beta-like 1 4.02518
MLANA melan-A 4.02518
WNT8A wingless-type MMTV integration site family, member 8A 4.02518
CRYGA crystallin, gamma A 4.02518
FCAMR Fc receptor, IgA, IgM, high affinity 4.02518
DIO3 deiodinase, iodothyronine, type III 4.02518
OR52E4 olfactory receptor, family 52, subfamily E, member 4 4.02518
JCHAIN joining chain of multimeric IgA and IgM 4.02518
C21ORF140 chromosome 21 open reading frame 140 4.02518
CNTN6 contactin 6 4.02518
PRSS36 protease, serine, 36 4.02518
GPR84 G protein-coupled receptor 84 4.02518
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 4.02518
MYOM3 myomesin 3 4.02518
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase 4.02518
F7 coagulation factor VII (serum prothrombin conversion accelerator) 4.02518
C9ORF152 chromosome 9 open reading frame 152 4.02518
RGPD4 RANBP2-like and GRIP domain containing 4 4.02518
CRH corticotropin releasing hormone 4.02518
RLN3 relaxin 3 4.02518
ASGR2 asialoglycoprotein receptor 2 4.02518
MYL4 myosin, light chain 4, alkali; atrial, embryonic 4.02518
R3HDML R3H domain containing-like 4.02518
IQSEC3 IQ motif and Sec7 domain 3 4.02518
APOA5 apolipoprotein A-V 4.02518
MYPN myopalladin 4.02518
NLRP13 NLR family, pyrin domain containing 13 4.02518
IL17F interleukin 17F 4.02518
NKPD1 NTPase, KAP family P-loop domain containing 1 4.02518
BANF2 barrier to autointegration factor 2 4.02518
IFITM10 interferon induced transmembrane protein 10 4.02518
NFE2 nuclear factor, erythroid 2 4.02518
HIGD1C HIG1 hypoxia inducible domain family, member 1C 4.02518
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 4.02518
ARSH arylsulfatase family, member H 4.02518
TLDC2 TBC/LysM-associated domain containing 2 4.02518
FGF6 fibroblast growth factor 6 4.02518
PCDHGA12 protocadherin gamma subfamily A, 12 4.02518
FAM81B family with sequence similarity 81, member B 4.02518
DHRS9 dehydrogenase/reductase (SDR family) member 9 4.02518
GRM6 glutamate receptor, metabotropic 6 4.02518
DSPP dentin sialophosphoprotein 4.02518
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 4.02518
MYH13 myosin, heavy chain 13, skeletal muscle 4.02518
GLIPR1L2 GLI pathogenesis-related 1 like 2 4.02518
RLBP1 retinaldehyde binding protein 1 4.02518
OR2A2 olfactory receptor, family 2, subfamily A, member 2 4.02518
PRB1 proline-rich protein BstNI subfamily 1 4.02518
GPR75 G protein-coupled receptor 75 4.02518
CST11 cystatin 11 4.02518
TACR2 tachykinin receptor 2 4.02518
ZACN zinc activated ligand-gated ion channel 4.02518
OVOL3 ovo-like zinc finger 3 4.02518
NKX2-4 NK2 homeobox 4 4.02518
IRF5 interferon regulatory factor 5 4.02518
SCRT2 scratch family zinc finger 2 4.02518
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 4.02518
TBX3 T-box 3 4.02518
CD79A CD79a molecule, immunoglobulin-associated alpha 4.02518
CKM creatine kinase, muscle 4.02518
MAG myelin associated glycoprotein 4.02518
OR7C1 olfactory receptor, family 7, subfamily C, member 1 4.02518
NXPE1 neurexophilin and PC-esterase domain family, member 1 4.02518
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 4.02518
USP26 ubiquitin specific peptidase 26 4.02518
SLC26A9 solute carrier family 26 (anion exchanger), member 9 4.02518
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 4.02518
OR10A3 olfactory receptor, family 10, subfamily A, member 3 4.02518
C8ORF48 chromosome 8 open reading frame 48 4.02518
SKOR1 SKI family transcriptional corepressor 1 4.02518
SSMEM1 serine-rich single-pass membrane protein 1 4.02518
OLFM4 olfactomedin 4 4.02518
LRRC73 leucine rich repeat containing 73 4.02518
RPE65 retinal pigment epithelium-specific protein 65kDa 4.02518
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 4.02518
TIMD4 T-cell immunoglobulin and mucin domain containing 4 4.02518
PEAR1 platelet endothelial aggregation receptor 1 4.02518
CTRC chymotrypsin C (caldecrin) 4.02518
ADGRE1 adhesion G protein-coupled receptor E1 4.02518
DUXB double homeobox B 4.02518
CD19 CD19 molecule 4.02518
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 4.02518
PKP1 plakophilin 1 4.02518
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 4.02518
GRXCR2 glutaredoxin, cysteine rich 2 4.02518
CCNB3 cyclin B3 4.02518
MFAP4 microfibrillar-associated protein 4 4.02518
CXCR6 chemokine (C-X-C motif) receptor 6 4.02518
EZHIP EZH inhibitory protein 4.02518
PLA1A phospholipase A1 member A 4.02518
H4C12 H4 clustered histone 12 4.02518
PRR35 proline rich 35 4.02518
IMPG1 interphotoreceptor matrix proteoglycan 1 4.02518
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 4.02518
NHERF4 NHERF family PDZ scaffold protein 4 4.02518
AMN amnion associated transmembrane protein 4.02518
C2CD4A C2 calcium-dependent domain containing 4A 4.02518
C22ORF42 chromosome 22 open reading frame 42 4.02518
PEAK3 PEAK family member 3 4.02518
STPG3 sperm-tail PG-rich repeat containing 3 4.02518
DGCR6 DiGeorge syndrome critical region gene 6 4.02518
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 4.02518
PTF1A pancreas specific transcription factor, 1a 4.02518
GLT1D1 glycosyltransferase 1 domain containing 1 4.02518
F2RL3 coagulation factor II (thrombin) receptor-like 3 4.02518
AKNAD1 AKNA domain containing 1 4.02518
ACP4 acid phosphatase 4 4.02518
PIP prolactin-induced protein 4.02518
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 4.02518
LITAFD LITAF domain containing 4.02518
WNT10B wingless-type MMTV integration site family, member 10B 4.02518
WNT2 wingless-type MMTV integration site family member 2 4.02518
CLEC18A C-type lectin domain family 18, member A 4.02518
CCDC70 coiled-coil domain containing 70 4.02518
EOMES eomesodermin 4.02518
MB myoglobin 4.02518
ACKR5 atypical chemokine receptor 5 4.02518
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 4.02518
WASL-DT WASL divergent transcript 4.02518
CLEC1A C-type lectin domain family 1, member A 4.02518
PDCD1LG2 programmed cell death 1 ligand 2 4.02518
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 4.02518
GSTA2 glutathione S-transferase alpha 2 4.02518
DLX2 distal-less homeobox 2 4.02518
PRSS33 protease, serine, 33 4.02518
LY9 lymphocyte antigen 9 4.02518
PSG8 pregnancy specific beta-1-glycoprotein 8 4.02518
LYPD5 LY6/PLAUR domain containing 5 4.02518
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 4.02518
AQP8 aquaporin 8 4.02518
TGM6 transglutaminase 6 4.02518
HTRA4 HtrA serine peptidase 4 4.02518
SP100 SP100 nuclear antigen 4.02518
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 4.02518
PROP1 PROP paired-like homeobox 1 4.02518
BDKRB1 bradykinin receptor B1 4.02518
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.02518
H1-6 H1.6 linker histone, cluster member 4.02518
CD177 CD177 molecule 4.02518
DNAAF1 dynein, axonemal, assembly factor 1 4.02518
AQP10 aquaporin 10 4.02518
TTC36 tetratricopeptide repeat domain 36 4.02518
IFNE interferon, epsilon 4.02518
TEX38 testis expressed 38 4.02518
PTPN6 protein tyrosine phosphatase, non-receptor type 6 4.02518
SMPX small muscle protein, X-linked 4.02518
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 4.02518
TMEM86A transmembrane protein 86A 4.02518
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 4.02518
FADS6 fatty acid desaturase 6 4.02518
RBMXL3 RNA binding motif protein, X-linked-like 3 4.02518
EDN3 endothelin 3 4.02518
AQP9 aquaporin 9 4.02518
OTC ornithine carbamoyltransferase 4.02518
DEFB131B defensin beta 131B 4.02518
KRTAP21-2 keratin associated protein 21-2 4.02518
PLA2G4D phospholipase A2, group IVD (cytosolic) 4.02518
HSF4 heat shock transcription factor 4 4.02518
THTPA thiamine triphosphatase 4.02518
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 4.02518
LRRC46 leucine rich repeat containing 46 4.02518
CYP8B1 cytochrome P450, family 8, subfamily B, polypeptide 1 4.02518
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 4.02518
CCL24 chemokine (C-C motif) ligand 24 4.02518
DUSP13B dual specificity phosphatase 13B 3.96479
FGF22 fibroblast growth factor 22 3.45947
SCN2A sodium channel, voltage gated, type II alpha subunit 3.45947
WDR90 WD repeat domain 90 3.28233
WDR75 WD repeat domain 75 3.1293
MAPRE1 microtubule-associated protein, RP/EB family, member 1 3.05354
EXD3 exonuclease 3'-5' domain containing 3 3.02832
ASGR1 asialoglycoprotein receptor 1 3.02796
POU6F2 POU class 6 homeobox 2 2.92473
FGF16 fibroblast growth factor 16 2.89528
MMP3 matrix metallopeptidase 3 2.89528
MSC musculin 2.89528
BARX1 BARX homeobox 1 2.89528
HSPB2 heat shock 27kDa protein 2 2.89528
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2 2.8936
GOLGA8B golgin A8 family, member B 2.74639
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) 2.74398
PPT1 palmitoyl-protein thioesterase 1 2.72508
RHBDL2 rhomboid, veinlet-like 2 (Drosophila) 2.6867
LSR lipolysis stimulated lipoprotein receptor 2.63451
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 2.59894
RBM26 RNA binding motif protein 26 2.58641
H2AC21 H2A clustered histone 21 2.556
RPS27L ribosomal protein S27-like 2.53089
LZTFL1 leucine zipper transcription factor-like 1 2.45576
GLB1L galactosidase, beta 1-like 2.42703
MCOLN1 mucolipin 1 2.38902
ATP5MF ATP synthase membrane subunit f 2.3807
PTPMT1 protein tyrosine phosphatase, mitochondrial 1 2.38001
PGK1 phosphoglycerate kinase 1 2.36519
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 2.3422
CLDN20 claudin 20 2.33547
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 2.29075
DYNLL1 dynein, light chain, LC8-type 1 2.25313
PRAF2 PRA1 domain family, member 2 2.25112
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 2.25112
ELOA elongin A 2.24801
SLITRK4 SLIT and NTRK-like family, member 4 2.24654
ANKRD63 ankyrin repeat domain 63 2.23885
CP ceruloplasmin (ferroxidase) 2.23507
ERP29 endoplasmic reticulum protein 29 2.23494
TSPAN2 tetraspanin 2 2.2196
VSIG10L V-set and immunoglobulin domain containing 10 like 2.18629
GATD3 glutamine amidotransferase class 1 domain containing 3 2.18629
FOXRED2 FAD-dependent oxidoreductase domain containing 2 2.18404
ADD2 adducin 2 (beta) 2.18404
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 2.18249
ABI1 abl-interactor 1 2.17784
PSPC1 paraspeckle component 1 2.15401
SCYL1 SCY1-like 1 (S. cerevisiae) 2.13795
SLC66A3 solute carrier family 66 member 3 2.13336
LDOC1 leucine zipper, down-regulated in cancer 1 2.12996
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 2.12993
LASP1 LIM and SH3 protein 1 2.12811
GFM1 G elongation factor, mitochondrial 1 2.10944
BCAT1 branched chain amino-acid transaminase 1, cytosolic 2.10913
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 2.10337
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 2.09268
APLP2 amyloid beta (A4) precursor-like protein 2 2.07708
ANKDD1A ankyrin repeat and death domain containing 1A 2.06615
RITA1 RBPJ interacting and tubulin associated 1 2.05939
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 2.05106
AZIN2 antizyme inhibitor 2 2.04658
SNX6 sorting nexin 6 2.03996
FDX1 ferredoxin 1 2.02845
ZNF574 zinc finger protein 574 2.00325
FSBP fibrinogen silencer binding protein 2.00309
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 2.00246

decreased expression

Symbol Name Standardized Value
LOC114841035 uncharacterized LOC114841035 -4.02518
SPINK1 serine peptidase inhibitor, Kazal type 1 -4.02518
SLC16A14 solute carrier family 16, member 14 -4.02518
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -4.02518
PARP10 poly (ADP-ribose) polymerase family, member 10 -4.02518
CORO6 coronin 6 -4.02518
CXCR5 chemokine (C-X-C motif) receptor 5 -4.02518
CXCR4 chemokine (C-X-C motif) receptor 4 -4.02518
ZFAND5 zinc finger, AN1-type domain 5 -4.02518
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) -4.02518
BRDT bromodomain, testis-specific -4.02518
VWC2L von Willebrand factor C domain containing protein 2-like -4.02518
AQP1 aquaporin 1 (Colton blood group) -4.02518
SLC26A7 solute carrier family 26 (anion exchanger), member 7 -4.02518
RORC RAR-related orphan receptor C -4.02518
MZB1 marginal zone B and B1 cell-specific protein -4.02518
IQCN IQ motif containing N -4.02518
PIRT phosphoinositide-interacting regulator of transient receptor potential channels -4.02518
TUBA4B tubulin, alpha 4b -4.02518
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -4.02518
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 -4.02518
FAM178B family with sequence similarity 178, member B -4.02518
TRIM7 tripartite motif containing 7 -4.02518
PLCD4 phospholipase C, delta 4 -4.02518
GOLGA6L4 golgin A6 family-like 4 -4.02518
LECT2 leukocyte cell-derived chemotaxin 2 -4.02518
HIGD2B HIG1 hypoxia inducible domain family, member 2B -4.02518
FAM43A family with sequence similarity 43, member A -3.96576
NRG1 neuregulin 1 -3.87503
NSUN6 NOP2/Sun domain family, member 6 -3.28679
VCAN versican -3.25907
GMFB glia maturation factor, beta -2.95448
NKD2 naked cuticle homolog 2 (Drosophila) -2.92104
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) -2.92104
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein -2.92104
LRRIQ3 leucine-rich repeats and IQ motif containing 3 -2.92104
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase -2.83231
PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 -2.83231
HP1BP3 heterochromatin protein 1, binding protein 3 -2.82834
RNF111 ring finger protein 111 -2.8268
EIF4E3 eukaryotic translation initiation factor 4E family member 3 -2.82578
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -2.80301
NIPAL2 NIPA-like domain containing 2 -2.79049
KIF20A kinesin family member 20A -2.75076
MED20 mediator complex subunit 20 -2.66579
TRIM61 tripartite motif containing 61 -2.66341
ZNF610 zinc finger protein 610 -2.5904
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 -2.52803
TMEM203 transmembrane protein 203 -2.4819
ZNF761 zinc finger protein 761 -2.48007
TMEM232 transmembrane protein 232 -2.43195
KIRREL1 kirre like nephrin family adhesion molecule 1 -2.42764
MAP3K9 mitogen-activated protein kinase kinase kinase 9 -2.42716
FBXO17 F-box protein 17 -2.41531
ECI2 enoyl-CoA delta isomerase 2 -2.38496
ADGRF3 adhesion G protein-coupled receptor F3 -2.36942
BRD3OS BRD3 opposite strand -2.36519
ODC1 ornithine decarboxylase 1 -2.34501
DRD4 dopamine receptor D4 -2.3422
SFRP5 secreted frizzled-related protein 5 -2.3422
DLX4 distal-less homeobox 4 -2.3422
HELB helicase (DNA) B -2.31822
MEMO1 mediator of cell motility 1 -2.31209
DNLZ DNL-type zinc finger -2.28734
N4BP2L1 NEDD4 binding protein 2-like 1 -2.25998
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) -2.23728
PTPRD protein tyrosine phosphatase, receptor type, D -2.23507
SZT2 seizure threshold 2 homolog (mouse) -2.23494
WNT3 wingless-type MMTV integration site family, member 3 -2.23248
RIN1 Ras and Rab interactor 1 -2.2196
PTGER3 prostaglandin E receptor 3 (subtype EP3) -2.2196
TGFBRAP1 transforming growth factor, beta receptor associated protein 1 -2.20989
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 -2.20972
ADGRE2 adhesion G protein-coupled receptor E2 -2.19863
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 -2.19051
GPAT3 glycerol-3-phosphate acyltransferase 3 -2.19051
TMEM61 transmembrane protein 61 -2.19051
FBXO10 F-box protein 10 -2.17975
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -2.17354
OSBPL3 oxysterol binding protein-like 3 -2.1594
FMO5 flavin containing monooxygenase 5 -2.15657
FGF13 fibroblast growth factor 13 -2.13986
CADPS2 Ca++-dependent secretion activator 2 -2.10337
SLC26A8 solute carrier family 26 (anion exchanger), member 8 -2.10077
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 -2.09526
SLC38A10 solute carrier family 38, member 10 -2.09268
TMC7 transmembrane channel-like 7 -2.09268
POU3F1 POU class 3 homeobox 1 -2.07069
GALC galactosylceramidase -2.05759
AGFG2 ArfGAP with FG repeats 2 -2.05695
LINC02610 long intergenic non-protein coding RNA 2610 -2.05695
FANCL Fanconi anemia, complementation group L -2.05695
THSD4 thrombospondin, type I, domain containing 4 -2.05487
NKX1-2 NK1 homeobox 2 -2.05277
P4HA3 prolyl 4-hydroxylase, alpha polypeptide III -2.04862
RINL Ras and Rab interactor-like -2.03203
C14ORF93 chromosome 14 open reading frame 93 -2.02626
GPR19 G protein-coupled receptor 19 -2.01663
FAAP24 FA core complex associated protein 24 -2.01232