RPS6KA3 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description ribosomal protein S6 kinase, 90kDa, polypeptide 3|This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6197)
External Link http://www.ncbi.nlm.nih.gov/gene/6197
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Genes

34 substrates of the kinase RPS6KA3 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ATF4 activating transcription factor 4
BAD BCL2-associated agonist of cell death
CASP8 caspase 8, apoptosis-related cysteine peptidase
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CIC capicua transcriptional repressor
CREB1 cAMP responsive element binding protein 1
DAPK1 death-associated protein kinase 1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ESR1 estrogen receptor 1
FGFR1 fibroblast growth factor receptor 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
H3F3B H3 histone, family 3B (H3.3B)
HIST1H2BB histone cluster 1, H2bb
HIST1H3A histone cluster 1, H3a
HMGN1 high mobility group nucleosome binding domain 1
KCNK3 potassium channel, two pore domain subfamily K, member 3
MAP3K5 mitogen-activated protein kinase kinase kinase 5
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
PPP1R3A protein phosphatase 1, regulatory subunit 3A
RANBP3 RAN binding protein 3
RPS6 ribosomal protein S6
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TH tyrosine hydroxylase
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
WWC1 WW and C2 domain containing 1
YBX1 Y box binding protein 1