RPS6KA4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description ribosomal protein S6 kinase, 90kDa, polypeptide 4|This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8986)
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Genes

317 genes differentially expressed following the RPS6KA4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 3.51197
CD6 CD6 molecule 3.51197
C11ORF91 chromosome 11 open reading frame 91 3.51197
C11ORF96 chromosome 11 open reading frame 96 3.51197
HNF4A hepatocyte nuclear factor 4, alpha 3.51197
BMX BMX non-receptor tyrosine kinase 3.51197
ARHGAP36 Rho GTPase activating protein 36 3.51197
ALOX5AP arachidonate 5-lipoxygenase-activating protein 3.51197
LTB lymphotoxin beta (TNF superfamily, member 3) 3.51197
C8ORF48 chromosome 8 open reading frame 48 3.51197
RNASE12 ribonuclease, RNase A family, 12 (non-active) 3.51197
OAZ3 ornithine decarboxylase antizyme 3 3.51197
HLX H2.0-like homeobox 3.51197
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.51197
C1QTNF1 C1q and tumor necrosis factor related protein 1 3.51197
SMIM22 small integral membrane protein 22 3.51197
SPDYE6 speedy/RINGO cell cycle regulator family member E6 3.51197
LBHD1 LBH domain containing 1 3.51197
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 3.51197
LOC122539214 Zinc finger protein LOC122539214 3.51197
ADAT3 adenosine deaminase, tRNA-specific 3 3.51197
CCDC198 coiled-coil domain containing 198 3.51197
GPR149 G protein-coupled receptor 149 3.51197
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 3.51197
CFHR3 complement factor H-related 3 3.41856
KNG1 kininogen 1 3.41856
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 3.41856
COL20A1 collagen, type XX, alpha 1 3.41856
OR52H1 olfactory receptor, family 52, subfamily H, member 1 3.41856
GPR55 G protein-coupled receptor 55 3.41856
CARD16 caspase recruitment domain family, member 16 3.41856
GAST gastrin 3.41856
BSND barttin CLCNK-type chloride channel accessory beta subunit 3.41856
CELA3A chymotrypsin-like elastase family, member 3A 3.41856
LCN15 lipocalin 15 3.41856
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 3.41856
MPL MPL proto-oncogene, thrombopoietin receptor 3.41856
PRSS41 protease, serine, 41 3.41856
BMP3 bone morphogenetic protein 3 3.41856
FAM181B family with sequence similarity 181, member B 3.41856
PRR22 proline rich 22 3.41856
TECTB tectorin beta 3.41856
C3ORF22 chromosome 3 open reading frame 22 3.41856
UBE2U ubiquitin-conjugating enzyme E2U (putative) 3.41856
CASP4 caspase 4, apoptosis-related cysteine peptidase 3.41856
TM4SF20 transmembrane 4 L six family member 20 3.41856
PRL prolactin 3.41856
SLC25A45 solute carrier family 25, member 45 3.41856
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 3.41856
PAX2 paired box 2 3.41856
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 3.41856
MYOM2 myomesin 2 3.41856
IL23R interleukin 23 receptor 3.41856
GPR6 G protein-coupled receptor 6 3.41856
FPR2 formyl peptide receptor 2 3.41856
ZNF705B zinc finger protein 705B 3.41856
MYEOV myeloma overexpressed 3.41856
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 3.41856
STMN4 stathmin-like 4 3.41856
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 3.41856
C1ORF74 chromosome 1 open reading frame 74 3.41856
LTB4R2 leukotriene B4 receptor 2 3.41856
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.41856
ROPN1L rhophilin associated tail protein 1-like 3.41856
TBXT T-box transcription factor T 3.41856
ANKRD40CL ANKRD40 C-terminal like 3.41856
TENT5D terminal nucleotidyltransferase 5D 3.41856
GCNA germ cell nuclear acidic peptidase 3.41856
TBC1D3I TBC1 domain family member 3I 3.41856
PRR20G proline rich 20G 3.41856
SPMIP9 sperm microtubule inner protein 9 3.41856
GATA3 GATA binding protein 3 3.41856
MROH5 maestro heat-like repeat family member 5 3.41856
C1ORF87 chromosome 1 open reading frame 87 3.41856
ITK IL2-inducible T-cell kinase 3.41856
PMIS2 PMIS2 transmembrane protein 3.41856
OR51B5 olfactory receptor, family 51, subfamily B, member 5 3.41856
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 3.41856
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 3.41856
DMBX1 diencephalon/mesencephalon homeobox 1 3.41856
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.41856
MYH13 myosin, heavy chain 13, skeletal muscle 3.41856
SH3TC2 SH3 domain and tetratricopeptide repeats 2 3.41856
RNF113B ring finger protein 113B 3.41856
TBX3 T-box 3 3.41856
MYOT myotilin 3.41856
EXOC3L4 exocyst complex component 3-like 4 3.41856
CDKN2A cyclin-dependent kinase inhibitor 2A 3.41856
ALG10B ALG10B, alpha-1,2-glucosyltransferase 3.41856
SPMAP1 sperm microtubule associated protein 1 3.41856
SOST sclerostin 3.41856
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 3.41856
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.41856
SHOX2 short stature homeobox 2 3.41856
NXNL1 nucleoredoxin-like 1 3.41856
AQP8 aquaporin 8 3.41856
C9ORF64 chromosome 9 open reading frame 64 3.41856
CTAGE4 CTAGE family, member 4 3.41856
MKRN3 makorin ring finger protein 3 3.41856
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 3.41856
MYF6 myogenic factor 6 (herculin) 3.41856
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 3.41856
SUN3 Sad1 and UNC84 domain containing 3 3.41856
LPAR5 lysophosphatidic acid receptor 5 3.41856
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 3.41856
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.41856
CIDEC cell death-inducing DFFA-like effector c 3.41856
KRT15 keratin 15, type I 3.41856
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 3.41856
TEX19 testis expressed 19 3.41856
AKNAD1 AKNA domain containing 1 3.41856
CDH19 cadherin 19, type 2 3.41856
APOC4 apolipoprotein C-IV 3.41856
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 3.41856
POU4F1 POU class 4 homeobox 1 3.41856
HLA-G major histocompatibility complex, class I, G 3.41856
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 3.41856
CNR2 cannabinoid receptor 2 (macrophage) 3.41856
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 3.41856
LRRC26 leucine rich repeat containing 26 3.41856
SIDT1 SID1 transmembrane family, member 1 3.41856
LHX5 LIM homeobox 5 3.41856
IBSP integrin-binding sialoprotein 3.41856
TRIM55 tripartite motif containing 55 3.41856
CGB2 chorionic gonadotropin, beta polypeptide 2 3.41856
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 3.41856
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 3.41856
UTS2R urotensin 2 receptor 3.41856
CHIT1 chitinase 1 (chitotriosidase) 3.41856
CTXN3 cortexin 3 3.41856
AMN amnion associated transmembrane protein 3.41856
ITGAD integrin, alpha D 3.41856
SLITRK6 SLIT and NTRK-like family, member 6 3.41856
WFDC10A WAP four-disulfide core domain 10A 3.41856
HHIPL2 HHIP-like 2 3.41856
PPP1R3G protein phosphatase 1, regulatory subunit 3G 3.41856
GREM1 gremlin 1, DAN family BMP antagonist 3.41856
TEX38 testis expressed 38 3.41856
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.41856
LRRC31 leucine rich repeat containing 31 3.41856
BIN2 bridging integrator 2 3.41856
GRAPL GRB2-related adaptor protein-like 3.41856
CGA glycoprotein hormones, alpha polypeptide 3.41856
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 3.41856
CSF1R colony stimulating factor 1 receptor 3.41856
KIF12 kinesin family member 12 3.41856
AREG amphiregulin 3.41856
RBP4 retinol binding protein 4, plasma 3.41856
CD33 CD33 molecule 3.41856
MNX1 motor neuron and pancreas homeobox 1 3.41856
EBI3 Epstein-Barr virus induced 3 3.41856
ANGPTL6 angiopoietin-like 6 3.41856
C1QTNF2 C1q and tumor necrosis factor related protein 2 3.30945
SYT1 synaptotagmin I 3.21653
POLA2 polymerase (DNA directed), alpha 2, accessory subunit 3.14591
TMEM102 transmembrane protein 102 3.1113
MDM4 MDM4, p53 regulator 3.06768
MSH2 mutS homolog 2 2.89236
RHCG Rh family, C glycoprotein 2.84446
ANO5 anoctamin 5 2.81779
HACD2 3-hydroxyacyl-CoA dehydratase 2 2.80104
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B 2.7822
TUBG2 tubulin, gamma 2 2.75871
FDX1 ferredoxin 1 2.63584
IPO8 importin 8 2.62853
SUGP1 SURP and G patch domain containing 1 2.61265
PHACTR2 phosphatase and actin regulator 2 2.58013
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 2.52678
FKBP10 FK506 binding protein 10, 65 kDa 2.52057
SRP19 signal recognition particle 19kDa 2.44798
TNNI3 troponin I type 3 (cardiac) 2.40847
INA internexin neuronal intermediate filament protein, alpha 2.40184
EEF1AKMT3 EEF1A lysine methyltransferase 3 2.39633
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 2.39633
CD226 CD226 molecule 2.39633
MLF1 myeloid leukemia factor 1 2.36901
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1 2.36762
PLSCR1 phospholipid scramblase 1 2.36178
SHISAL2B shisa like 2B 2.36055
KIZ kizuna centrosomal protein 2.30714
NTNG1 netrin G1 2.30567
ABT1 activator of basal transcription 1 2.27181
ZNF7 zinc finger protein 7 2.26773
KPNA7 karyopherin alpha 7 (importin alpha 8) 2.26257
TSPAN8 tetraspanin 8 2.25669
CD68 CD68 molecule 2.25669
FLRT3 fibronectin leucine rich transmembrane protein 3 2.25669
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G 2.25669
INPP1 inositol polyphosphate-1-phosphatase 2.25669
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.23616
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 2.23249
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 2.23249
STX4 syntaxin 4 2.18807
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 2.17529
BEND5 BEN domain containing 5 2.16343
ZCCHC4 zinc finger, CCHC domain containing 4 2.1555
CENPB centromere protein B, 80kDa 2.15397
C8ORF74 chromosome 8 open reading frame 74 2.1396
TICRR TOPBP1-interacting checkpoint and replication regulator 2.1327
C22ORF15 chromosome 22 open reading frame 15 2.12842
PBDC1 polysaccharide biosynthesis domain containing 1 2.12578
NBR1 neighbor of BRCA1 gene 1 2.1208
IRAK1 interleukin-1 receptor-associated kinase 1 2.09136
FN3KRP fructosamine 3 kinase related protein 2.08298
GFOD2 glucose-fructose oxidoreductase domain containing 2 2.0798
POLD2 polymerase (DNA directed), delta 2, accessory subunit 2.06242
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 2.05625
PKN2 protein kinase N2 2.05579
H3C4 H3 clustered histone 4 2.05384
INO80C INO80 complex subunit C 2.05098
FAM107A family with sequence similarity 107, member A 2.03331
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 2.03331

decreased expression

Symbol Name Standardized Value
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -3.51197
CEACAM19 carcinoembryonic antigen-related cell adhesion molecule 19 -3.51197
LIF leukemia inhibitory factor -3.51197
ZNF319 zinc finger protein 319 -3.51197
TCEAL1 transcription elongation factor A (SII)-like 1 -3.41856
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 -3.41856
CHRDL2 chordin-like 2 -3.41856
POU5F2 POU domain class 5, transcription factor 2 -3.41856
TEX46 testis expressed 46 -3.41856
ATG4A autophagy related 4A, cysteine peptidase -3.41856
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 -3.41856
ZNF471 zinc finger protein 471 -3.41856
ANKRD42-DT ANKRD42 divergent transcript -3.41856
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 -3.41856
SH2D6 SH2 domain containing 6 -3.41856
RTL5 retrotransposon Gag like 5 -3.41856
RAG1 recombination activating gene 1 -3.41856
SPRR2F small proline-rich protein 2F -3.41856
PLCZ1 phospholipase C, zeta 1 -3.41856
LENG1 leukocyte receptor cluster (LRC) member 1 -3.41856
UROC1 urocanate hydratase 1 -3.41856
POMC proopiomelanocortin -3.41856
LOC390937 Ets2 repressor factor-like -3.41856
IGFL4 IGF-like family member 4 -3.41856
PLA2G4D phospholipase A2, group IVD (cytosolic) -3.41856
EDN1 endothelin 1 -3.41856
MR1 major histocompatibility complex, class I-related -3.41856
OR52N2 olfactory receptor, family 52, subfamily N, member 2 -3.41856
ERICH6B glutamate-rich 6B -3.41856
TRIM54 tripartite motif containing 54 -3.41856
EPHA5 EPH receptor A5 -3.41856
GPR150 G protein-coupled receptor 150 -3.41856
PHOX2A paired-like homeobox 2a -3.41856
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 -3.41856
AQP5 aquaporin 5 -3.41856
RLF rearranged L-myc fusion -3.41856
GAL galanin/GMAP prepropeptide -3.41585
TLNRD1 talin rod domain containing 1 -3.36072
SNAP47 synaptosomal-associated protein, 47kDa -3.30558
TST thiosulfate sulfurtransferase (rhodanese) -3.22848
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) -3.22848
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -3.18357
LAT linker for activation of T cells -3.16037
NTF4 neurotrophin 4 -2.83539
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -2.80328
STPG1 sperm-tail PG-rich repeat containing 1 -2.72616
ELMOD2 ELMO/CED-12 domain containing 2 -2.71122
DIAPH3 diaphanous-related formin 3 -2.61766
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 -2.61509
EVA1A eva-1 homolog A (C. elegans) -2.59173
ABITRAM actin binding transcription modulator -2.59173
CDNF cerebral dopamine neurotrophic factor -2.58013
HYPK huntingtin interacting protein K -2.58013
SYNDIG1L synapse differentiation inducing 1-like -2.58013
PPIB peptidylprolyl isomerase B (cyclophilin B) -2.58013
ZNF284 zinc finger protein 284 -2.58013
GPRASP1 G protein-coupled receptor associated sorting protein 1 -2.58013
SKIC3 SKI3 subunit of superkiller complex -2.56678
MGST2 microsomal glutathione S-transferase 2 -2.56678
DSEL dermatan sulfate epimerase-like -2.54825
BCAN brevican -2.52057
RAB42 RAB42, member RAS oncogene family -2.49996
PPARA peroxisome proliferator-activated receptor alpha -2.45227
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 -2.44869
MYBBP1A MYB binding protein (P160) 1a -2.44798
FKBP6 FK506 binding protein 6, 36kDa -2.4473
MYT1L myelin transcription factor 1-like -2.44665
EPHB1 EPH receptor B1 -2.4343
ITLN2 intelectin 2 -2.43299
KDM6B lysine (K)-specific demethylase 6B -2.43299
EGFR epidermal growth factor receptor -2.37618
APOLTP apolipoprotein lipid transfer particle homolog -2.37286
NBEAL2 neurobeachin-like 2 -2.36055
OGA O-GlcNAcase -2.36055
GPKOW G patch domain and KOW motifs -2.35678
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -2.31151
LSG1 large 60S subunit nuclear export GTPase 1 -2.30714
ETV5 ets variant 5 -2.29431
BTN3A1 butyrophilin, subfamily 3, member A1 -2.2846
PYCR2 pyrroline-5-carboxylate reductase family, member 2 -2.26599
NR1H2 nuclear receptor subfamily 1, group H, member 2 -2.25026
ZNHIT2 zinc finger, HIT-type containing 2 -2.23616
ZNF594 zinc finger protein 594 -2.213
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 -2.19957
BAMBI BMP and activin membrane-bound inhibitor -2.17493
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 -2.17406
WDR6 WD repeat domain 6 -2.16937
LZTS1 leucine zipper, putative tumor suppressor 1 -2.16673
USP5 ubiquitin specific peptidase 5 (isopeptidase T) -2.16673
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -2.1396
LRP5 low density lipoprotein receptor-related protein 5 -2.13621
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -2.12381
ANKRD36B ankyrin repeat domain 36B -2.11919
PRADC1 protease-associated domain containing 1 -2.11316
FOXP4 forkhead box P4 -2.11316
SLC25A30 solute carrier family 25, member 30 -2.0964
SUMO3 small ubiquitin-like modifier 3 -2.09493
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 -2.09409
PSD pleckstrin and Sec7 domain containing -2.0755
NKAPD1 NKAP domain containing 1 -2.06778
PBX4 pre-B-cell leukemia homeobox 4 -2.06695
NMRAL1 NmrA-like family domain containing 1 -2.05729
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) -2.05729
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 -2.04807
RNF43 ring finger protein 43 -2.01982