RPS6KB1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description ribosomal protein S6 kinase, 70kDa, polypeptide 1|This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013] (NCBI Entrez Gene Database, 6198)
External Link http://www.ncbi.nlm.nih.gov/gene/6198
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Genes

119 interacting proteins for RPS6KB1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
AKT1 v-akt murine thymoma viral oncogene homolog 1
APP amyloid beta (A4) precursor protein
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCAR1 breast cancer anti-estrogen resistance 1
BTK Bruton agammaglobulinemia tyrosine kinase
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CLEC3B C-type lectin domain family 3, member B
COASY CoA synthase
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2B casein kinase 2, beta polypeptide
DEPTOR DEP domain containing MTOR-interacting protein
DPPA4 developmental pluripotency associated 4
E2F1 E2F transcription factor 1
EEF2K eukaryotic elongation factor 2 kinase
EIF3A eukaryotic translation initiation factor 3, subunit A
EIF3B eukaryotic translation initiation factor 3, subunit B
EIF3C eukaryotic translation initiation factor 3, subunit C
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF3H eukaryotic translation initiation factor 3, subunit H
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4B eukaryotic translation initiation factor 4B
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELAVL1 ELAV like RNA binding protein 1
EP300 E1A binding protein p300
ESR1 estrogen receptor 1
FMR1 fragile X mental retardation 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GLI1 GLI family zinc finger 1
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GSK3B glycogen synthase kinase 3 beta
HNF4A hepatocyte nuclear factor 4, alpha
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HTT huntingtin
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IL2 interleukin 2
IRS1 insulin receptor substrate 1
ITGA6 integrin, alpha 6
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KAT2B K(lysine) acetyltransferase 2B
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK1 mitogen-activated protein kinase 1
MAPK15 mitogen-activated protein kinase 15
MAPK3 mitogen-activated protein kinase 3
MAPK6 mitogen-activated protein kinase 6
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAPKAP1 mitogen-activated protein kinase associated protein 1
MAPT microtubule-associated protein tau
MAX MYC associated factor X
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MXD1 MAX dimerization protein 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NDRG2 NDRG family member 2
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEK6 NIMA-related kinase 6
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NRF1 nuclear respiratory factor 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLD2 phospholipase D2
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRKCZ protein kinase C, zeta
PTK2 protein tyrosine kinase 2
PXN paxillin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RBX1 ring-box 1, E3 ubiquitin protein ligase
RHEB Ras homolog enriched in brain
RICTOR RPTOR independent companion of MTOR, complex 2
RPS6 ribosomal protein S6
RPTOR regulatory associated protein of MTOR, complex 1
RXRA retinoid X receptor, alpha
RXRB retinoid X receptor, beta
RXRG retinoid X receptor, gamma
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STK11 serine/threonine kinase 11
SYK spleen tyrosine kinase
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TGFB3 transforming growth factor, beta 3
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TP63 tumor protein p63
TRAF4 TNF receptor-associated factor 4
TRIB2 tribbles pseudokinase 2
UBC ubiquitin C
URI1 URI1, prefoldin-like chaperone
XPO1 exportin 1