RPS6KB1 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description ribosomal protein S6 kinase, 70kDa, polypeptide 1|This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013] (NCBI Entrez Gene Database, 6198)
External Link http://www.ncbi.nlm.nih.gov/gene/6198
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Genes

29 substrates of the kinase RPS6KB1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CREM cAMP responsive element modulator
DEPTOR DEP domain containing MTOR-interacting protein
EEF2K eukaryotic elongation factor 2 kinase
EIF4B eukaryotic translation initiation factor 4B
ESR1 estrogen receptor 1
FMR1 fragile X mental retardation 1
GLI1 GLI family zinc finger 1
GRIA1 glutamate receptor, ionotropic, AMPA 1
GSK3B glycogen synthase kinase 3 beta
IRS1 insulin receptor substrate 1
MAPT microtubule-associated protein tau
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MXD1 MAX dimerization protein 1
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NDRG2 NDRG family member 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
RICTOR RPTOR independent companion of MTOR, complex 2
RPS6 ribosomal protein S6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
STK11 serine/threonine kinase 11
TP63 tumor protein p63
TRIB2 tribbles pseudokinase 2
URI1 URI1, prefoldin-like chaperone