| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/234811 |
| Similar Terms | |
| Downloads & Tools |
195 proteins with high or low expression in RRD-251 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TPM4 | tropomyosin 4 | 1.01 |
| TPM3 | tropomyosin 3 | 0.89 |
| TPM1 | tropomyosin 1 (alpha) | 0.84 |
| SPATA2 | spermatogenesis associated 2 | 0.63 |
| DUSP14 | dual specificity phosphatase 14 | 0.58 |
| SIMC1 | SUMO-interacting motifs containing 1 | 0.55 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | 0.53 |
| CPPED1 | calcineurin-like phosphoesterase domain containing 1 | 0.53 |
| CD99 | CD99 molecule | 0.53 |
| ANKS6 | ankyrin repeat and sterile alpha motif domain containing 6 | 0.53 |
| HPCAL4 | hippocalcin like 4 | 0.52 |
| FTL | ferritin, light polypeptide | 0.51 |
| TRIM16 | tripartite motif containing 16 | 0.5 |
| BAG4 | BCL2-associated athanogene 4 | 0.48 |
| STMN2 | stathmin 2 | 0.48 |
| SUCO | SUN domain containing ossification factor | 0.47 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.46 |
| INPP5E | inositol polyphosphate-5-phosphatase, 72 kDa | 0.46 |
| YAP1 | Yes-associated protein 1 | 0.46 |
| PTMS | parathymosin | 0.45 |
| POLR2M | polymerase (RNA) II (DNA directed) polypeptide M | 0.45 |
| MXRA7 | matrix-remodelling associated 7 | 0.45 |
| TPM2 | tropomyosin 2 (beta) | 0.45 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | 0.45 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | 0.44 |
| S100A6 | S100 calcium binding protein A6 | 0.44 |
| TXN2 | thioredoxin 2 | 0.43 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | 0.43 |
| FSTL1 | follistatin-like 1 | 0.43 |
| CD58 | CD58 molecule | 0.42 |
| PAIP2 | poly(A) binding protein interacting protein 2 | 0.41 |
| VSNL1 | visinin-like 1 | 0.41 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.41 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.4 |
| S100A4 | S100 calcium binding protein A4 | 0.4 |
| TRAM2 | translocation associated membrane protein 2 | 0.39 |
| NDST1 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 | 0.39 |
| CLTB | clathrin, light chain B | 0.39 |
| CDA | cytidine deaminase | 0.38 |
| NUP62 | nucleoporin 62kDa | 0.38 |
| ZNF428 | zinc finger protein 428 | 0.38 |
| ZNF714 | zinc finger protein 714 | 0.38 |
| KCNAB2 | potassium channel, voltage gated subfamily A regulatory beta subunit 2 | 0.37 |
| PSME1 | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 0.37 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.37 |
| ATP5IF1 | ATP synthase inhibitory factor subunit 1 | 0.37 |
| OSTF1 | osteoclast stimulating factor 1 | 0.37 |
| ENTPD2 | ectonucleoside triphosphate diphosphohydrolase 2 | 0.36 |
| ELK1 | ELK1, member of ETS oncogene family | 0.35 |
| TANK | TRAF family member-associated NFKB activator | 0.35 |
| SLC44A2 | solute carrier family 44 (choline transporter), member 2 | 0.35 |
| HLA-B | major histocompatibility complex, class I, B | 0.35 |
| B4GALT2 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | 0.35 |
| CHTF8 | CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) | 0.35 |
| MRPL33 | mitochondrial ribosomal protein L33 | 0.35 |
| BCL9 | B-cell CLL/lymphoma 9 | 0.35 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.34 |
| SOD1 | superoxide dismutase 1, soluble | 0.34 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.34 |
| F8A1 | coagulation factor VIII-associated 1 | 0.34 |
| HYPK | huntingtin interacting protein K | 0.34 |
| BAG3 | BCL2-associated athanogene 3 | 0.34 |
| ZNF526 | zinc finger protein 526 | 0.33 |
| ZYX | zyxin | 0.33 |
| AGFG2 | ArfGAP with FG repeats 2 | 0.33 |
| VSIR | V-set immunoregulatory receptor | 0.33 |
| ZNF771 | zinc finger protein 771 | 0.33 |
| SGTA | small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha | 0.33 |
| LSM3 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.33 |
| BACH1 | BTB and CNC homology 1, basic leucine zipper transcription factor 1 | 0.33 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.32 |
| TOB1 | transducer of ERBB2, 1 | 0.32 |
| MAP3K11 | mitogen-activated protein kinase kinase kinase 11 | 0.32 |
| TMEM173 | transmembrane protein 173 | 0.32 |
| C12ORF73 | chromosome 12 open reading frame 73 | 0.32 |
| ZNF580 | zinc finger protein 580 | 0.32 |
| TNS4 | tensin 4 | 0.32 |
| SF3B4 | splicing factor 3b, subunit 4, 49kDa | 0.31 |
| STMN1 | stathmin 1 | 0.31 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.31 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.31 |
| RING1 | ring finger protein 1 | 0.31 |
| ZNF185 | zinc finger protein 185 (LIM domain) | 0.31 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.31 |
| RNASET2 | ribonuclease T2 | 0.3 |
| NAXE | NAD(P)HX epimerase | 0.3 |
| TMSB10 | thymosin beta 10 | 0.3 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.3 |
| PEX14 | peroxisomal biogenesis factor 14 | 0.3 |
| SMC1B | structural maintenance of chromosomes 1B | 0.3 |
| C5ORF51 | chromosome 5 open reading frame 51 | 0.3 |
| CAMK1 | calcium/calmodulin-dependent protein kinase I | 0.3 |
| RPLP2 | ribosomal protein, large, P2 | 0.3 |
| UNG | uracil-DNA glycosylase | 0.3 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | 0.29 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -2.92 |
| VAV1 | vav 1 guanine nucleotide exchange factor | -2.15 |
| MTUS2 | microtubule associated tumor suppressor candidate 2 | -1.4 |
| MYT1 | myelin transcription factor 1 | -1.02 |
| NEK4 | NIMA-related kinase 4 | -0.99 |
| USP6NL | USP6 N-terminal like | -0.85 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | -0.8 |
| ADPRH | ADP-ribosylarginine hydrolase | -0.8 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.78 |
| FRMD6 | FERM domain containing 6 | -0.77 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | -0.74 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.72 |
| TMEM200A | transmembrane protein 200A | -0.69 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | -0.69 |
| SPATA33 | spermatogenesis associated 33 | -0.68 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.67 |
| TNXB | tenascin XB | -0.63 |
| RCBTB1 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 | -0.6 |
| TMEM222 | transmembrane protein 222 | -0.6 |
| AREL1 | apoptosis resistant E3 ubiquitin protein ligase 1 | -0.6 |
| ZNF280B | zinc finger protein 280B | -0.58 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -0.57 |
| CEP112 | centrosomal protein 112kDa | -0.57 |
| GRTP1 | growth hormone regulated TBC protein 1 | -0.56 |
| LSM11 | LSM11, U7 small nuclear RNA associated | -0.55 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | -0.54 |
| FCSK | fucose kinase | -0.51 |
| QSOX2 | quiescin Q6 sulfhydryl oxidase 2 | -0.51 |
| CEP290 | centrosomal protein 290kDa | -0.51 |
| ABHD4 | abhydrolase domain containing 4 | -0.5 |
| MLXIPL | MLX interacting protein-like | -0.48 |
| DMWD | dystrophia myotonica, WD repeat containing | -0.47 |
| TUBA1C | tubulin, alpha 1c | -0.46 |
| TOP1MT | topoisomerase (DNA) I, mitochondrial | -0.46 |
| SNRNP48 | small nuclear ribonucleoprotein 48kDa (U11/U12) | -0.46 |
| CHKB | choline kinase beta | -0.46 |
| MAPK9 | mitogen-activated protein kinase 9 | -0.45 |
| EIF2B4 | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa | -0.44 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | -0.43 |
| ALG3 | ALG3, alpha-1,3- mannosyltransferase | -0.43 |
| RNASEL | ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) | -0.42 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.42 |
| RPL37 | ribosomal protein L37 | -0.41 |
| ARL13B | ADP-ribosylation factor-like 13B | -0.41 |
| CCDC71 | coiled-coil domain containing 71 | -0.4 |
| SYTL3 | synaptotagmin-like 3 | -0.39 |
| FBXO31 | F-box protein 31 | -0.39 |
| L1RE1 | LINE1 retrotransposable element 1 | -0.38 |
| COA6 | cytochrome c oxidase assembly factor 6 | -0.38 |
| FNIP1 | folliculin interacting protein 1 | -0.37 |
| WNT10B | wingless-type MMTV integration site family, member 10B | -0.37 |
| PES1 | pescadillo ribosomal biogenesis factor 1 | -0.37 |
| SIVA1 | SIVA1, apoptosis-inducing factor | -0.36 |
| PAAF1 | proteasomal ATPase-associated factor 1 | -0.36 |
| PIP | prolactin-induced protein | -0.36 |
| RP9 | retinitis pigmentosa 9 (autosomal dominant) | -0.36 |
| CENPS | centromere protein S | -0.35 |
| FBXO42 | F-box protein 42 | -0.35 |
| SLC25A21 | solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 | -0.34 |
| MTF1 | metal-regulatory transcription factor 1 | -0.34 |
| OTC | ornithine carbamoyltransferase | -0.34 |
| FN1 | fibronectin 1 | -0.34 |
| TRAF4 | TNF receptor-associated factor 4 | -0.33 |
| ACTBL2 | actin, beta-like 2 | -0.32 |
| GAS6 | growth arrest-specific 6 | -0.32 |
| RNF26 | ring finger protein 26 | -0.32 |
| METTL9 | methyltransferase like 9 | -0.32 |
| LAMTOR2 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 | -0.32 |
| EEF2KMT | eukaryotic elongation factor 2 lysine methyltransferase | -0.32 |
| NOL12 | nucleolar protein 12 | -0.32 |
| NADK | NAD kinase | -0.32 |
| MAN2C1 | mannosidase, alpha, class 2C, member 1 | -0.32 |
| CCDC77 | coiled-coil domain containing 77 | -0.32 |
| MOCS1 | molybdenum cofactor synthesis 1 | -0.32 |
| SRPX | sushi-repeat containing protein, X-linked | -0.31 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.31 |
| CLCN2 | chloride channel, voltage-sensitive 2 | -0.31 |
| PLEC | plectin | -0.31 |
| MT2A | metallothionein 2A | -0.31 |
| MAGEA12 | melanoma antigen family A12 | -0.31 |
| CCNF | cyclin F | -0.3 |
| SQSTM1 | sequestosome 1 | -0.3 |
| NET1 | neuroepithelial cell transforming 1 | -0.3 |
| R3HDM4 | R3H domain containing 4 | -0.3 |
| ADAT2 | adenosine deaminase, tRNA-specific 2 | -0.3 |
| KIAA0586 | KIAA0586 | -0.3 |
| UPP1 | uridine phosphorylase 1 | -0.3 |
| ABCD4 | ATP-binding cassette, sub-family D (ALD), member 4 | -0.3 |
| CHST14 | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 | -0.29 |
| SCRN3 | secernin 3 | -0.29 |
| TMOD2 | tropomodulin 2 (neuronal) | -0.29 |
| PARL | presenilin associated, rhomboid-like | -0.29 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | -0.29 |
| ARHGAP23 | Rho GTPase activating protein 23 | -0.29 |
| GTF3A | general transcription factor IIIA | -0.29 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -0.29 |
| FAM160B2 | family with sequence similarity 160, member B2 | -0.29 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | -0.29 |
| MRPL35 | mitochondrial ribosomal protein L35 | -0.29 |
| DAB2IP | DAB2 interacting protein | -0.29 |
