RRM1 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description ribonucleotide reductase M1|This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6240)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_RRM1
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Genes

171 co-expressed genes for RRM1 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
AFG3L2 AFG3-like AAA ATPase 2
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
AURKA aurora kinase A
AURKB aurora kinase B
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
CCNA2 cyclin A2
CCNB2 cyclin B2
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CDC20 cell division cycle 20
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CHERP calcium homeostasis endoplasmic reticulum protein
CKS2 CDC28 protein kinase regulatory subunit 2
CS citrate synthase
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DTYMK deoxythymidylate kinase (thymidylate kinase)
DUT deoxyuridine triphosphatase
E2F8 E2F transcription factor 8
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ESD esterase D
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FH fumarate hydratase
FOXM1 forkhead box M1
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
GPN1 GPN-loop GTPase 1
GTF2A2 general transcription factor IIA, 2, 12kDa
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HADH hydroxyacyl-CoA dehydrogenase
HAT1 histone acetyltransferase 1
HCFC1 host cell factor C1
HDAC2 histone deacetylase 2
HDDC2 HD domain containing 2
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPM heterogeneous nuclear ribonucleoprotein M
HNRNPR heterogeneous nuclear ribonucleoprotein R
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSPE1 heat shock 10kDa protein 1
IARS isoleucyl-tRNA synthetase
IMMT inner membrane protein, mitochondrial
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KHSRP KH-type splicing regulatory protein
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
LBR lamin B receptor
LMNB2 lamin B2
LRPPRC leucine-rich pentatricopeptide repeat containing
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
METAP2 methionyl aminopeptidase 2
MFAP1 microfibrillar-associated protein 1
MKI67 marker of proliferation Ki-67
MRPL35 mitochondrial ribosomal protein L35
MSH2 mutS homolog 2
MT1JP metallothionein 1J, pseudogene
NAE1 NEDD8 activating enzyme E1 subunit 1
NASP nuclear autoantigenic sperm protein (histone-binding)
NDC80 NDC80 kinetochore complex component
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
NONO non-POU domain containing, octamer-binding
NUDC nudC nuclear distribution protein
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUP37 nucleoporin 37kDa
NUSAP1 nucleolar and spindle associated protein 1
PA2G4 proliferation-associated 2G4, 38kDa
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP1 poly (ADP-ribose) polymerase 1
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PLK4 polo-like kinase 4
PMEL premelanosome protein
POM121 POM121 transmembrane nucleoporin
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PTGES3 prostaglandin E synthase 3 (cytosolic)
R3HDM1 R3H domain containing 1
RACGAP1 Rac GTPase activating protein 1
RAD51AP1 RAD51 associated protein 1
RAD54L RAD54-like (S. cerevisiae)
RAN RAN, member RAS oncogene family
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RUVBL2 RuvB-like AAA ATPase 2
SAFB scaffold attachment factor B
SERBP1 SERPINE1 mRNA binding protein 1
SHCBP1 SHC SH2-domain binding protein 1
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SLBP stem-loop binding protein
SMC1A structural maintenance of chromosomes 1A
SMC2 structural maintenance of chromosomes 2
SMC3 structural maintenance of chromosomes 3
SMC4 structural maintenance of chromosomes 4
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SNRPA small nuclear ribonucleoprotein polypeptide A
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNRPG small nuclear ribonucleoprotein polypeptide G
SPAG5 sperm associated antigen 5
SRRM1 serine/arginine repetitive matrix 1
SRSF1 serine/arginine-rich splicing factor 1
SSBP1 single-stranded DNA binding protein 1, mitochondrial
SSRP1 structure specific recognition protein 1
STMN1 stathmin 1
TARS threonyl-tRNA synthetase
TCP1 t-complex 1
TFDP1 transcription factor Dp-1
TMPO thymopoietin
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRA2B transformer 2 beta homolog (Drosophila)
TTK TTK protein kinase
TUBA3C tubulin, alpha 3c
TXNL4A thioredoxin-like 4A
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
USP1 ubiquitin specific peptidase 1
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
VDAC1 voltage-dependent anion channel 1
VDAC2 voltage-dependent anion channel 2
VRK1 vaccinia related kinase 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
XPO1 exportin 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
YARS tyrosyl-tRNA synthetase
ZWINT ZW10 interacting kinetochore protein