RRM2 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description ribonucleotide reductase M2|This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 6241)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_RRM2
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Genes

40 co-expressed genes for RRM2 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FOXM1 forkhead box M1
GMNN geminin, DNA replication inhibitor
H2AFX H2A histone family, member X
HMMR hyaluronan-mediated motility receptor (RHAMM)
KIF11 kinesin family member 11
KIF18B kinesin family member 18B
LMNB1 lamin B1
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
NDC80 NDC80 kinetochore complex component
NUSAP1 nucleolar and spindle associated protein 1
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SMC1A structural maintenance of chromosomes 1A
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
ZWINT ZW10 interacting kinetochore protein